1,833 research outputs found
Exploring the Collective Phenomenon at the Electron-Ion Collider
Based on rare fluctuations in strong interactions, we argue that there is a
strong physical resemblance between the high multiplicity events in
photo-nuclear collisions and those in collisions, in which interesting
long range collective phenomena are discovered. This indicates that the
collectivity can also be studied in certain kinematic region of the upcoming
Electron-Ion Collider (EIC) where the incoming virtual photon has a
sufficiently long lifetime. Using a model in the Color Glass Condensate
formalism, we first show that the initial state interactions can explain the
recent ATLAS azimuthal correlation results measured in the photo-nuclear
collisions, and then we provide quantitative predictions for the long range
correlations in collisions in the EIC regime. With the unprecedented
precision and the ability to change the size of the collisional system, the
high luminosity EIC will open a new window to explore the physical mechanism
responsible for the collective phenomenon.Comment: 6 pages, 3 figures; published versio
Knockdown of Rab5a expression decreases cancer cell motility and invasion through integrin-mediated signaling pathway
<p>Abstract</p> <p>Background</p> <p>Rab GTPases function as modulators in intracellular transport. Rab5a, a member of the Rab subfamily of small GTPases, is an important regulator of vesicle traffic from the plasma membrane to early endosomes. Recent findings have reported that Rab5a gene was involved in the progression of cancer. In the present study, we investigated the effect of Rab5a on cervical cancer invasion and metastasis and the molecular mechanism underlying the involvement of Rab5a.</p> <p>Methods</p> <p>Rab5a expression was assessed by immunohistochemical analysis on a cervical cancer tissue microarray. RNA interference (RNAi) was performed to knock down the endogenous expression of Rab5a gene in HeLa and SiHa cells. Cell motility was evaluated using invasion assay and wound migration assay <it>in vitro</it>. The expression levels of integrin-associated molecules were detected by Western blot and immunofluorescence.</p> <p>Results</p> <p>We found that Rab5a was expressed at a high level in cervical cancer tissues. Silencing of Rab5a expression significantly decreased cancer cell motility and invasiveness. The down-regulation of integrin-associated focal adhesion signaling molecules was further detected in Rab5a knockdown cells. Meanwhile, active GTP-bound Rac1, Cdc42, and RhoA were also down-regulated, accompanied with the reduction in the number and size of filopodia and lamellipodia.</p> <p>Conclusions</p> <p>Taken together, these data suggest that Rab5a functions in regulating the invasion phenotype, and we propose that this regulation may be via integrin-mediated signaling pathway in cervical cancer cells.</p
AquaÂ[1-(1,10-phenanthrolin-2-yl-κ2 N,N′)-1H-pyrazol-3-amine-κN 2](sulfato-κO)copper(II) methanol monosolvate dihydrate
In the title compound, [Cu(SO4)(C15H11N5)(H2O)]·CH3OH·2H2O, the CuII ion is in a distorted square-pyramidal geometry, in which three N atoms from the chelating 1-(1,10-phenanthrolin-2-yl)-1H-pyrazol-3-amine ligand and one O atom from a sulfate anion define the basal plane and the O atom from the coordinating water molÂecule is located at the apex. In the crystal, hydrogen-bonding interÂactions involving the coordinating and solvent water molÂecules, the methanol solvent molÂecule and the amine group (one with an intraÂmolecular interÂaction to one of the sulfate O atoms) of the complex are observed. π–π interÂactions between symmetry-related phenantroline moieties, with a shortest centroid–centroid interÂaction of 3.573 (2)°, are also present
Piperazine-2,3,5,6-tetraÂone
The molÂecule of the title compound, C4H2N2O4, is located around an inversion center and the four O atoms are in the 2,3,5,6-positions of the piperazine ring. In the crystal, bifurcated N—H⋯O hydrogen bonds link the molÂecules into a corrugated layer parallel to (101)
Expanded CURB-65: A new score system predicts severity of community-acquired pneumonia with superior efficiency
Aim of this study was to develop a new simpler and more effective severity score for communityacquired pneumonia (CAP) patients. A total of 1640 consecutive hospitalized CAP patients in Second
Affiliated Hospital of Zhejiang University were included. The effectiveness of different pneumonia
severity scores to predict mortality was compared, and the performance of the new score was validated
on an external cohort of 1164 patients with pneumonia admitted to a teaching hospital in Italy.
Using age≥ 65 years, LDH>230u/L, albumin<3.5g/dL, platelet count<100×109/L, confusion,
urea>7mmol/L, respiratory rate≥30/min, low blood pressure, we assembled a new severity score
named as expanded-CURB-65. The 30-day mortality and length of stay were increased along with
increased risk score. The AUCs in the prediction of 30-day mortality in the main cohort were 0.826
(95%CI, 0.807–0.844), 0.801 (95%CI, 0.781–0.820), 0.756 (95%CI, 0.735–0.777), 0.793 (95%CI,
0.773–0.813) and 0.759 (95%CI, 0.737–0.779) for the expanded-CURB-65, PSI, CURB-65, SMART-COP
and A-DROP, respectively. The performance of this bedside score was confirmed in CAP patients of
the validation cohort although calibration was not successful in patients with health care-associated
pneumonia (HCAP). The expanded CURB-65 is objective, simpler and more accurate scoring system for
evaluation of CAP severity, and the predictive efficiency was better than other score systems
Automated turnkey microcomb for low-noise microwave synthesis
Microresonator-based optical frequency comb (microcomb) has the potential to
revolutionize the accuracy of frequency synthesizer in radar and communication
applications. However, fundamental limit exists for low noise microcomb
generation, especially in low size, weight, power and cost (SWaP-C) package.
Here we resolve this limit, by the demonstration of an automated turnkey
microcomb, operating close to its low quantum-limited phase noise, within a
compact setup size of 85 mm * 90 mm * 25 mm. High quality factor fiber
Fabry-Perot resonator (FFPR), with Q up to 4.0 * 10^9, is the key for both low
quantum noise and pump noise limit, in the diode-pump case in a self-injection
locking scheme. Low phase noise of -80 and -105 dBc/Hz at 100 Hz, -106 and -125
dBc/Hz at 1 kHz, -133 and -148 dBc/Hz at 10 kHz is achieved at 10.1 GHz and 1.7
GHz repetition frequencies, respectively. With the simultaneous automated
turnkey, low-noise and direct-diode-pump capability, our microcomb is ready to
be used as a low-noise frequency synthesizer with low SWaP-C and thus field
deployability
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