Modeling and Evolutionary Optimization on Multilevel Production Scheduling: A Case Study

Multilevel production scheduling problem is a typical combinatorial optimization problem in a manufacturing system, which is traditionally modeled as several hierarchical sublevel problems and optimized at each level, respectively. An integrated model, which can cope with the whole multilevel scheduling information simultaneously, is proposed in this paper, and a specific evolutionary algorithm is designed to solve the integrated model with a twin-screw coding strategy. In order to evaluate the performance of the new algorithm, a real 3-level production scheduling problem is employed for case study, and two typical metaheuristic algorithms, a genetic algorithm (GA) and a simulated annealing (SA), are also employed for comparison study. Experimental simulation results show that our proposed modeling and optimization method has outperformed the other ones

Submerged Floating Tunnels under Seismic Motion: Vibration Mitigation and Seaquake effects

In this work the activity of the research group active at Politecnico di Milano in the field of the dynamic behavior of Submerged Floating Tunnels (SFTs) is reviewed, with emphasis on the possibility to mitigate the dynamic response through structural control solutions and the modeling of seaquake effects. A SFT model, equipped with suitable passive control devices, is accounted as a case study to assess the vibration mitigation under strong seismic motions. Elastic-plastic axial springs restrain the tunnel at the shores, and bars made of inelastic material anchor the tunnel to the seabed. Earthquake and seaquake motions are introduced accounting for spatial variability of the seabed motion during an earthquake. Some conclusions are drawn from a comparison between the response of the case study SFT due to earthquake and earthquake plus seaquake, which point out as seaquake forces can be an important source of excitation for SFTs. The paucity of studies on this topic, as well as the extent of the effects induced, call for further researches and developments

C. elegans fatty acid two-hydroxylase regulates intestinal homeostasis by affecting heptadecenoic acid production

Background/Aims: The hydroxylation of fatty acids at the C-2 position is the first step of fatty acid α-oxidation and generates sphingolipids containing 2-hydroxy fatty acyl moieties. Fatty acid 2-hydroxylation is catalyzed by Fatty acid 2-hydroxylase (FA2H) enzyme. However, the precise roles of FA2H and fatty acid 2-hydroxylation in whole cell homeostasis still remain unclear. Methods: Here we utilize Caenorhabditis elegans as the model and systemically investigate the physiological functions of FATH-1/C25A1.5, the highly conserved worm homolog for mammalian FA2H enzyme. Immunostaining, dye-staining and translational fusion reporters were used to visualize FATH-1 protein and a variety of subcellular structures. The “click chemistry” method was employed to label 2-OH fatty acid in vivo. Global and tissue-specific RNAi knockdown experiments were performed to inactivate FATH-1 function. Lipid analysis of the fath-1 deficient mutants was achieved by mass spectrometry. Results: C. elegans FATH-1 is expressed at most developmental stages and in most tissues. Loss of fath-1 expression results in severe growth retardation and shortened lifespan. FATH-1 function is crucially required in the intestine but not the epidermis with stereospecificity. The “click chemistry” labeling technique showed that the FATH-1 metabolites are mainly enriched in membrane structures preferable to the apical side of the intestinal cells. At the subcellular level, we found that loss of fath-1 expression inhibits lipid droplets formation, as well as selectively disrupts peroxisomes and apical endosomes. Lipid analysis of the fath-1 deficient animals revealed a significant reduction in the content of heptadecenoic acid, while other major FAs remain unaffected. Feeding of exogenous heptadecenoic acid (C17: 1), but not oleic acid (C18: 1), rescues the global and subcellular defects of fath-1 knockdown worms. Conclusion: Our study revealed that FATH-1 and its catalytic products are highly specific in the context of chirality, C-chain length, spatial distribution, as well as the types of cellular organelles they affect. Such an unexpected degree of specificity for the synthesis and functions of hydroxylated FAs helps to regulate protein transport and fat metabolism, therefore maintaining the cellular homeostasis of the intestinal cells. These findings may help our understanding of FA2H functions across species, and offer potential therapeutical targets for treating FA2H-related diseases

The Teaching Reform and Practice of Ideological and Political Construction of the Course on Food Chemistry and Analysis in the Digital Intelligence Era

As the new orientation, new requirement and new task to develop higher education, it is necessary to deeply implement the digital strategic action, construct a new form of higher education teaching, give full play to the role of the main channel in the classroom education, and comprehensively promote the ideological and political construction of curriculum. On the basis of the digital intelligence era, this paper deeply explores the ideological and political elements in each chapter according to the characteristics of the course, teaching objectives and teaching contents; it also draws the conclusion about the teaching reform and practice of the ideological and political construction of the course on Food Chemistry and Analysis. It puts forward some strategies: the improvement on educator' ideological and political teaching ability, the digital construction and improvement of high-quality ideological and political resources, the optimization of curriculum setting, and the innovation on "gene implantation" and "one, two, three, four" teaching modes. The ideological and political classroom of professional courses is taken as the carrier, the unity of inner knowledge and action is realized, and meanwhile the ideological and political education system is constructed about the course on Food Chemistry and Analysis, with the purpose to promote both the translation of professional knowledge and value guidance of students', and create a new pattern for the moral education

Therapeutic Effects of Chinese Medicine Herb Pair, Huzhang and Guizhi, on Monosodium Urate Crystal-Induced Gouty Arthritis in Rats Revealed by Anti-Inflammatory Assessments and NMR-Based Metabonomics

The present study was undertaken to evaluate the therapeutic effects of Huzhang-Guizhi herb pair (HG), firstly included in Hu-Zhang Power documented in Taiping Shenghui Fang, on monosodium urate (MSU) crystals-induced gouty arthritis in rats. We found that pretreatment with HG in rats with gouty arthritis could significantly attenuate the ankle joint swelling, and this beneficial antigout effect might be mediated, at least in part, by inhibiting tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) production in synovial fluid as well as nuclear transcription factor-κB p65 (NF-κB p65) protein expression in synovial tissue. Moreover, metabonomic analysis demonstrated that 5 and 6 potential biomarkers associated with gouty arthritis in plasma and urine, respectively, which were mainly involved in energy metabolism, amino acid metabolism, and gut microbe metabolism, were identified. HG could reverse the pathological process of MSU-induced gouty arthritis through regulating the disturbed metabolic pathways. These results provided important mechanistic insights into the protective effects of HG against MSU-induced gouty arthritis in rats

An Exposome Atlas of Serum Reveals the Risk of Chronic Diseases in the Chinese Population

Although adverse environmental exposures are considered a major cause of chronic diseases, current studies provide limited information on real-world chemical exposures and related risks. For this study, we collected serum samples from 5696 healthy people and patients, including those with 12 chronic diseases, in China and completed serum biomonitoring including 267 chemicals via gas and liquid chromatography-tandem mass spectrometry. Seventy-four highly frequently detected exposures were used for exposure characterization and risk analysis. The results show that region is the most critical factor influencing human exposure levels, followed by age. Organochlorine pesticides and perfluoroalkyl substances are associated with multiple chronic diseases, and some of them exceed safe ranges. Multi-exposure models reveal significant risk effects of exposure on hyperlipidemia, metabolic syndrome and hyperuricemia. Overall, this study provides a comprehensive human serum exposome atlas and disease risk information, which can guide subsequent in-depth cause-and-effect studies between environmental exposures and human health