57 research outputs found
Hypervelocity Stars from the Andromeda Galaxy
Hypervelocity stars (HVSs) discovered in the Milky Way (MW) halo are thought
to be ejected from near the massive black hole (MBH) at the galactic centre. In
this paper we investigate the spatial and velocity distributions of the HVSs
which are expected to be similarly produced in the Andromeda galaxy (M31). We
consider three different HVS production mechanisms: (i) the disruption of
stellar binaries by the galactocentric MBH; (ii) the ejection of stars by an
in-spiraling intermediate mass black hole; and (iii) the scattering of stars
off a cluster of stellar-mass black holes orbiting around the MBH. While the
first two mechanisms would produce large numbers of HVSs in M31, we show that
the third mechanism would not be effective in M31. We numerically calculate
1.2*10^6 trajectories of HVSs from M31 within a simple model of the Local Group
and hence infer the current distribution of these stars. Gravitational focusing
of the HVSs by the MW and the diffuse Local Group medium leads to high
densities of low mass (~ solar mass) M31 HVSs near the MW. Within the
virialized MW halo, we expect there to be of order 1000 HVSs for the first
mechanism and a few hundred HVSs for the second mechanism; many of these stars
should have distinctively large approach velocities (< -500 km/s). In addition,
we predict ~5 hypervelocity RGB stars within the M31 halo which could be
identified observationally. Future MW astrometric surveys or searches for
distant giants could thus find HVSs from M31.Comment: 14 pages, 6 figures, changed to match version accepted by MNRA
Dissipative Chaos in Semiconductor Superlattices
We consider the motion of ballistic electrons in a miniband of a
semiconductor superlattice (SSL) under the influence of an external,
time-periodic electric field. We use the semi-classical balance-equation
approach which incorporates elastic and inelastic scattering (as dissipation)
and the self-consistent field generated by the electron motion. The coupling of
electrons in the miniband to the self-consistent field produces a cooperative
nonlinear oscillatory mode which, when interacting with the oscillatory
external field and the intrinsic Bloch-type oscillatory mode, can lead to
complicated dynamics, including dissipative chaos. For a range of values of the
dissipation parameters we determine the regions in the amplitude-frequency
plane of the external field in which chaos can occur. Our results suggest that
for terahertz external fields of the amplitudes achieved by present-day free
electron lasers, chaos may be observable in SSLs. We clarify the nature of this
novel nonlinear dynamics in the superlattice-external field system by exploring
analogies to the Dicke model of an ensemble of two-level atoms coupled with a
resonant cavity field and to Josephson junctions.Comment: 33 pages, 8 figure
Opportunities for improving animal welfare in rodent models of epilepsy and seizures
Animal models of epilepsy and seizures, mostly involving mice and rats, are used to understand the pathophysiology of the different forms of epilepsy and their comorbidities, to identify biomarkers, and to discover new antiepileptic drugs and treatments for comorbidities. Such models represent an important area for application of the 3Rs (replacement, reduction and refinement of animal use). This report provides background information and recommendations aimed at minimising pain, suffering and distress in rodent models of epilepsy and seizures in order to improve animal welfare and optimise the quality of studies in this area. The report includes practical guidance on principles of choosing a model, induction procedures, in vivo recordings, perioperative care, welfare assessment, humane endpoints, social housing, environmental enrichment, reporting of studies and data sharing. In addition, some model-specific welfare considerations are discussed, and data gaps and areas for further research are identified. The guidance is based upon a systematic review of the scientific literature, survey of the international epilepsy research community, consultation with veterinarians and animal care and welfare officers, and the expert opinion and practical experience of the members of a Working Group convened by the United Kingdom's National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs)
Summary of Lepton Photon 2011
In this lecture, I summarize developments presented at the Lepton Photon 2011
conference and give my perspective on the current situation in high-energy
physics.Comment: 56 pages, 37 figures; v2: minor corrections to reference
Private Sector Union Density and the Wage Premium: Past, Present, and Future
The rise and decline of private sector unionization were among the more important features of the U.S. labor market during the twentieth century. Following a dramatic spurt in unionization after passage of the depression-era National Labor Relations Act (NLRA) of 1935, union density peaked in the mid-1950s, and then began a continuous decline. At the end of the century, the percentage of private wage and salary workers who were union members was less than 10 percent, not greatly different from union density prior to the NLRA
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
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