Myxoid Neurothekeoma: A Rare Soft Tissue Tumor of Hand in a Male Toddler

Neurothekeomas are rare benign neoplasms, typically occurring in young patients with a remarkable predilection for the female population. Patients usually present with a small nodule in different anatomical sites, commonly  involving the face and the upper limb. We report a case of a three.year.old  boy, who presented with a nontender nodule on the left thumb. Surgical biopsy and immunostaining confirmed the diagnosis as myxoid neurothekeoma. The rarity of this unusual skin tumor in a toddler prompted the following report.Keywords: Neurothekeoma, soft tissue tumor, toddle

Evaluation of two mobile health apps in the context of smoking cessation: qualitative study of cognitive behavioral therapy (CBT) versus non-CBT-based digital solutions.

BACKGROUND: Mobile health (mHealth) apps can offer users numerous benefits, representing a feasible and acceptable means of administering health interventions such as cognitive behavioral therapy (CBT). CBT is commonly used in the treatment of mental health conditions, where it has a strong evidence base, suggesting that it represents an effective method to elicit health behavior change. More importantly, CBT has proved to be effective in smoking cessation, in the context of smoking-related costs to the National Health Service (NHS) having been estimated to be as high as £2.6bn in 2015. Although the evidence base for computerized CBT in mental health is strong, there is limited literature on its use in smoking cessation. This, combined with the cost-effectiveness of mHealth interventions, advocates a need for research into the effectiveness of CBT-based smoking cessation apps. OBJECTIVE: The objective of this study was, first, to explore participants' perceptions of 2 mHealth apps, a CBT-based app, Quit Genius, and a non-CBT-based app, NHS Smokefree, over a variety of themes. Second, the study aimed to investigate the perceptions and health behavior of users of each app with respect to smoking cessation. METHODS: A qualitative short-term longitudinal study was conducted, using a sample of 29 smokers allocated to one of the 2 apps, Quit Genius or Smokefree. Each user underwent 2 one-to-one semistructured interviews, 1 week apart. Thematic analysis was carried out, and important themes were identified. Descriptive statistics regarding participants' perceptions and health behavior in relation to smoking cessation are also provided. RESULTS: The thematic analysis resulted in five higher themes and several subthemes. Participants were generally more positive about Quit Genius's features, as well as about its design and information engagement and quality. Quit Genius users reported increased motivation to quit smoking, as well as greater willingness to continue using their allocated app after 1 week. Moreover, these participants demonstrated preliminary changes in their smoking behavior, although this was in the context of our limited sample, not yet allowing for the finding to be generalizable. CONCLUSIONS: Our findings underscore the use of CBT in the context of mHealth apps as a feasible and potentially effective smoking cessation tool. mHealth apps must be well developed, preferably with an underlying behavioral change mechanism, to promote positive health behavior change. Digital CBT has the potential to become a powerful tool in overcoming current health care challenges. The present results should be replicated in a wider sample using the apps for a longer period so as to allow for generalizability. Further research is also needed to focus on the effect of greater personalization on behavioral change and on understanding the psychological barriers to the adoption of new mHealth solutions

The generalized 3-edge-connectivity of lexicographic product graphs

The generalized $k$-edge-connectivity $\lambda_k(G)$ of a graph $G$ is a generalization of the concept of edge-connectivity. The lexicographic product of two graphs $G$ and $H$, denoted by $G\circ H$, is an important graph product. In this paper, we mainly study the generalized 3-edge-connectivity of $G \circ H$, and get upper and lower bounds of $\lambda_3(G \circ H)$. Moreover, all bounds are sharp.Comment: 14 page

Whole genome sequence analysis of the TALLYHO/Jng mouse

Background: The TALLYHO/Jng (TH) mouse is a polygenic model for obesity and type 2 diabetes first described in the literature in 2001. The origin of the TH strain is an outbred colony of the Theiler Original strain and mice derived from this source were selectively bred for male hyperglycemia establishing an inbred strain at The Jackson Laboratory. TH mice manifest many of the disease phenotypes observed in human obesity and type 2 diabetes. Results: We sequenced the whole genome of TH mice maintained at Marshall University to a depth of approximately 64.8X coverage using data from three next generation sequencing runs. Genome-wide, we found approximately 4.31 million homozygous single nucleotide polymorphisms (SNPs) and 1.10 million homozygous small insertions and deletions (indels) of which 98,899 SNPs and 163,720 indels were unique to the TH strain compared to 28 previously sequenced inbred mouse strains. In order to identify potentially clinically-relevant genes, we intersected our list of SNP and indel variants with human orthologous genes in which variants were associated in GWAS studies with obesity, diabetes, and metabolic syndrome, and with genes previously shown to confer a monogenic obesity phenotype in humans, and found several candidate variants that could be functionally tested using TH mice. Further, we filtered our list of variants to those occurring in an obesity quantitative trait locus, tabw2, identified in TH mice and found a missense polymorphism in the Cidec gene and characterized this variant’s effect on protein function. Conclusions: We generated a complete catalog of variants in TH mice using the data from whole genome sequencing. Our findings will facilitate the identification of causal variants that underlie metabolic diseases in TH mice and will enable identification of candidate susceptibility genes for complex human obesity and type 2 diabetes

Mechanical Properties of Sugar Palm (Arenga pinnata Wurmb. Merr)/Glass Fiber-Reinforced Poly(lactic acid) Hybrid Composites for Potential Use in Motorcycle Components

This research aims to determine the mechanical properties of sugar palm fiber (Arenga pinnata Wurmb. Merr) (SPF)/glass fiber (GF)-reinforced poly(lactic acid) (PLA) hybrid composites for potential use in motorcycle components. The mechanical (hardness, compressive, impact, and creep) and flammability properties of SPF/GF/PLA hybrid composites were investigated and compared to commercially available motorcycle Acrylonitrile Butadiene Styrene (ABS) plastic components. The composites were initially prepared using a Brabender Plastograph, followed by a compression molding method. This study also illustrated the tensile and flexural stress–strain curves. The results revealed that alkaline-treated SPF/GF/PLA had the highest hardness and impact strength values of 88.6 HRS and 3.10 kJ/m2, respectively. According to the results, both alkaline and benzoyl chloride treatments may improve the mechanical properties of SPF/GF/PLA hybrid composites, and a short-term creep test revealed that the alkaline treated SPF/GF/PLA composite displayed the least creep deformation. The findings of the horizontal UL 94 testing indicated that the alkaline-treated SPF/GF/PLA hybrid composites had good flame resistance. However, alkaline-treated SPF/GF/PLA composites are more suitable materials for motorcycle components

13.MDI

Abstract Larvicidal potential of the extracts from different parts viz. green and red fruits, seeds, fruit without seeds, leaves and roots of Withania somnifera in different solvents was evaluated against larvae of Anopheles stephensi, Aedes aegypti and Culex quinquefasciatus, the important disease vectors prevalent in the semi-arid region. Experiments were carried out on late 3 rd or early 4 th instar larvae of these mosquitoes using standard WHO technique. 24 and 48 hr LC 50 values along with their 95% confidence limits, regression equation, chi-square (χ2)/ heterogeneity of the response have been determined by log probit regression analysis. The 24 hr LC 50 values as observed for whole green fruits in water, methanol and petroleum ether were 350.9, 372.4, 576.9; 115.0, 197.1, 554.6; 154.9, 312.0, 1085.0 while corresponding values for red fruits were 473.5, 406.4, 445.2; 94.7, 94.5, 1013.0; 241.8, 535.0, 893.3 mg l -1 for An. stephensi, Ae. aegypti and Cx. quinquefasciatus respectively showing that methanol extracts were more effective against anophelines as compared to culicines when whole fruits were taken. The 24 hr LC 50 values as observed for seeds in acetone, methanol and petroleum ether were 188.1, 777.5, 822.5; 245.5, 769.0, 1169.0; 140.3, 822.9, 778.4 and for fruit without seeds were 80. 2, 97.6, 146.6; 88.4, 404.4, 1030.0; 30.0, 44.5, 54.2 mg l -1 for the above mosquito species respectively showing that extract of fruit without seeds were most effective in petroleum ether followed by acetone and methanol extracts. However, experiments conducted with methanol extracts of leaves and roots of this plant species did not show any appreciable larvicidal activity and a 20-40% mortality was observed up to 500 mg l -1 of the extracts. Overall larvae of anophelines were found more susceptible as compared to culicines to all the extracts tested. Petroleum ether extract of fruit without seeds was found most effective against all the mosquito species showing that active ingredient might be present in this part of the plant species. The study would be of great importance while planning vector control strategy based on alternative plant derived insecticides

Physical, Mechanical, and Morphological Properties of Treated Sugar Palm/Glass Reinforced Poly(Lactic Acid) Hybrid Composites

This research was performed to evaluate the physical, mechanical, and morphological properties of treated sugar palm fiber (SPF)/glass fiber (GF) reinforced poly(lactic acid) (PLA) hybrid composites. Morphological investigations of tensile and flexural fractured samples of composites were conducted with the help of scanning electron microscopy (SEM). Alkaline and benzoyl chloride (BC) treatments of SPFs were performed. A constant weight fraction of 30% total fiber loading and 70% poly(lactic acid) were considered. The composites were initially prepared by a Brabender Plastograph, followed by a hot-pressing machine. The results reported that the best tensile and flexural strengths of 26.3 MPa and 27.3 MPa were recorded after alkaline treatment of SPF, while the highest values of tensile and flexural moduli of 607 MPa and 1847 MPa were recorded after BC treatment of SPF for SPF/GF/PLA hybrid composites. The novel SPF/GF/PLA hybrid composites could be suitable for fabricating automotive components