Land Grant Application- Sherman, James (Freeport)

Land grant application submitted to the Maine Land Office on behalf of James Sherman for service in the Revolutionary War, by their widow Margaret.https://digitalmaine.com/revolutionary_war_me_land_office/1810/thumbnail.jp

Financing Entrepreneurship Programs for Youth Transitioning Out of Foster Care

This publication is one of a series of briefs exploring strategies for financing supports and services that help youth in foster care make successful transitions to adulthood. The Finance Project produced this brief with support from the Foster Care Work Group. The Foster Care Work Group (FCWG) is one of three work groups of the Youth Transition Funders Group (YTFG), a collaboration of foundation leaders dedicated to improving the lives of the nation's most vulnerable young people. Foundation leaders participating in the YTFG are committed to achieving a common vision -- ensuring that vulnerable youth are connected by age 25 to institutions and support systems that will enable them to succeed throughout adulthood. The FCWG brings together foundation leaders with a shared interest in preparing youth in foster care for their transition out of the child welfare system and providing them pathways to lifelong economic well-being

Structure studies of cassaic acid

Thesis (Ph.D.)--Boston UniversityCassaic acid (I) is one of the hydrolysis products from cassaine, an alkaloid found in the bark of Erythrophleum guineense. Earlier investigators formulated cassaic acid as I-, with the hydroxyl and ketone groups placed provisionally at positions 2 and 9, respectively. The present work provides experimental evidence proving the correctness of these two assignments. [TRUNCATED

Modeling the Pancreatic α-Cell: Dual Mechanisms of Glucose Suppression of Glucagon Secretion

AbstractThe mechanism by which glucose induces insulin secretion in β-cells is fairly well understood. Despite years of research, however, the mechanism of glucagon secretion in α-cells is still not well established. It has been proposed that glucose regulates glucagon secretion by decreasing the conductance of either outward ATP-dependent potassium channels (K(ATP)) or an inward store-operated current (SOC). We have developed a mathematical model based on mouse data to test these hypotheses and found that both mechanisms are possible. Glucose metabolism closes K(ATP) channels, which depolarizes the cell but paradoxically reduces calcium influx by inactivating voltage-dependent calcium and sodium channels and decreases secretion. Glucose metabolism also activates SERCA pumps, which fills the endoplasmic reticulum and hyperpolarizes the cells by reducing the inward current through SOC channels and again suppresses glucagon secretion. We find further that the two mechanisms can combine to account for the nonmonotonic dependence of secretion on glucose observed in some studies, an effect that cannot be obtained with either mechanism alone

The Administration and Supervision Program in the Department of Leadership, Foundations, and Policy, Curry School of Education, University of Virginia

The Department of Leadership, Foundations, and Policy at the University of Virginia is designed to meet the demand for educational leaders who can combine vision and practice. It houses three integrated academic units: leadership; foundations; and policy. The leadership programs prepare leaders who are committed to social justice and formal education as a means of personal and civic improvement. Graduates of the programs go on to careers in school administration as well as university careers. Graduate students of the educational foundations programs learn concepts and skills related to research and evaluation, human development, learning and motivation, social and cultural contexts of education, multicultural education, new information technologies and education of gifted and talented students. They go on to careers in college teaching, research, instructional technology and administration. The policy studies programs are designed to help students understand and master the processes by which social, political and economic forces influence education policy. Graduates of these programs commonly assume positions in local, state and national or international agencies and organizations

An Annotated Bibliography of Lee, Otway, and Rowe, 1900-1974

To provide an annotated bibliography of criticism on the writings of Nathaniel Lee, Thomas Otway and Nicholas Rowe from 1900 to 1974 for students and scholars is the purpose of this study. The bibliography contains brief evaluations of each of the works, which are divided into the following categories: articles, books and chapters in books, and dissertations. An additional chapter includes those works which deal with two or more of the authors. The appendix contains a selected list of foreign language publications that concern the three playwrights

Necessary but not Sufficient: The Continuing Inequality between Men and Women in Educational Leadership, Findings from the AASA Mid-Decade Survey

The gender of school leaders makes a difference in career paths, personal life, and characteristics of workplace. There is additional evidence that men and women are appointed or elected to lead different kinds of educational jurisdictions. Even if those differences did not exist, equitable access to leadership positions for people of different backgrounds would make this an important issue. This article reports gender-related findings from the American Association of School Administrators 2015 Mid-Decade Survey. Findings confirm many of the trends in research on the superintendency over the past 15 years. The profiles of women superintendents are becoming more like their male counterparts. Both men and women appear to be less mobile than in the past. Men and women are spending about the same time as teachers before becoming superintendents, women and men appear to experience stress similarly, and women are receiving mentoring much more than in the past. There are few data to support the beliefs that women superintendents, more than men, are limited by family circumstance although this survey sheds no light on perspectives of women aspirants. This survey also confirms that there are a variety of paths to the position providing opportunities for women who have not necessarily had the typical teacher/principal/central office administrator trajectory. Nevertheless, significant differences still exist. Most important is that men are still four times more likely than women to serve in the most powerful position in education, and both women and men of color are still grossly underrepresented

Investigating How Calcium Diffusion Affects Metabolic Oscillations and Synchronization of Pancreatic Beta Cells

Diabetes is a disease characterized by improper concentrations of blood glucose due to irregular insulin production or sensitivity. Coupled in islets of Langerhans within the pancreas, β-cells are responsible for the production and regulation of insulin based on changes in glucose levels. Using the Dual Oscillator Model (DOM), we will examine how calcium handling between individual pancreatic β-cells affects the synchronization of metabolic oscillations within electrically coupled islets. Calcium permeability was implemented into the DOM, and numerical solutions of the system were obtained via MATLAB using a modified ordinary differential equation solver for stiff systems and the Automatic Differentiation for MATLAB software. We developed a synchronization index to quantitatively describe the synchronization of variables between nearest neighboring cells and throughout the islet as a whole. We considered how calcium permeability between heterogeneous cells affects the behavior of metabolic oscillations and their synchronization. In particular, we examined fructose-1, 6-bisphosphate. In our study metabolic oscillations were always maintained. We also showed that, for low to moderate levels of electrical coupling, calcium permeability increased the synchronization index, but increasing calcium permeability had little effect on synchronization when cells were already strongly synchronized with strong electrical coupling. Heterogeneity due to glucose influx or initial state of the cells had similar synchronization results

The Ursinus Weekly, January 15, 1909

Notice • Week of Prayer • The Dean\u27s column • Lectures • Basketball in the academy • Societies • Personals • Alumni notes • Advisory Council • Notes • Seminary notes • Group meetings • The Literary Supplement: An undemocratic constitution; The responsibilities of political power in the hands of the people; Two leading novelists of American fiction; The close of the year; The cry of the childrenhttps://digitalcommons.ursinus.edu/weekly/2855/thumbnail.jp

The Ursinus Weekly, May 21, 1909

Brotherhood of St. Paul fletcherizes • Buffalo Bill in Philadelphia • Malcolm Shackelford entertains audience • Glee club • Lecture • Baseball • Ursinus Union • Tennis tournament • Society notes • Alumni notes • Personals • Field house fund • Literary Supplement: A day in May; The power of sentiment; A generation of vipers; Literary criticism on Tolstoy; The power of ideas; Money and hypocrisyhttps://digitalcommons.ursinus.edu/weekly/2873/thumbnail.jp