3 research outputs found
PARVIMONAS MICRA AND FUSOBACTERIUM NUCLEATUM SEPTIC ARTHRITIS: A RARE ANAEROBIC DOUBLE TROUBLE
Septic arthritis is a condition initiated by pathogenic inoculation of joints either by direct or hematogenous route, necessitating immediate medical attention. Among aerobic bacteria, Staphylococcus aureus and Streptococcus spp. are commonly found in association with septic joints. Anaerobes are very rarely involved in the causation of septic arthritis with an estimated rate of <1%. We are presenting a case of septic arthritis of knee joint by Parvimonas micra and Fusobacterium nucleatum, both being constituents of microbial flora in the oral cavity and gastrointestinal tract. Gram stain and anaerobic culture incorporated along with the aerobic culture of synovial fluid have played an important role in the preliminary diagnosis of anaerobic septic arthritis in this case
Antimicrobial Susceptibility Profile of Clinical Isolates of Peptostreptococcus anaerobius
Gram-positive anaerobic cocci (GPAC) which are commonly known as Peptococci or
Peptostreptococci belong to the genus Peptostreptococcus. Peptostreptococcus anaerobius is
one of the most common GPAC known to be associated with infections of the abdominal cavity
and the female genitourinary tract. The present study aims at determining the antimicrobial
susceptibility profile of P. anaerobius isolates against various antimicrobials. This study was
conducted over a period of three years from January 2015 to December 2017 in the Department
of Microbiology of a tertiary care teaching hospital. Specimens like pus aspirates, soft tissue
and body fluids were included in the study. P. anaerobius isolates were identified by standard
methods and confirmed by automated mass spectrometry. Minimum inhibitory concentration
was determined by the reference agar dilution method for different anti-anaerobic agents. A total
of 30 P. anaerobius isolates were obtained from various infections with majority (n=21, 70%)
of the isolates being recovered from infections of the anatomical sites below the waistline. All
isolates showed excellent anti-anaerobic activity against metronidazole, penicillin G, cefoxitin
and chloramphenicol. Clindamycin resistance was noted in 53.3% (n=16) of P. anaerobius
isolates. None of the isolates were b-lactamase producers. Metronidazole which is considered
as the empirical therapy of choice for anaerobic infections was found to have excellent activity.
Significant resistance was noted towards clindamycin which is commonly used as an alternative
to metronidazole in suspected anaerobic infections. Routine sensitivity testing of clinical isolates
of anaerobes seems to be the need of the hour for effective patient management