The curvilinear relationship between daily time pressure and work engagement: The role of psychological capital and sleep

The present study focuses on the fluctuation in work engagement by examining the relationship between daily time pressure and daily work engagement. Based on the job demands-resources (JD-R) theory, this study also tests whether psychological capital and sleep moderate the influence of time pressure on work engagement. We conducted a diary study to gather 67 participants’ data over 10 consecutive work days (502 daily measurement points), including their daily time pressure, work engagement, and sleep quality. Our results indicate that there is a curvilinear relationship between daily time pressure and work engagement in the form of an inverted U-shape. If it was lower than the optimal level, daily time pressure as a challenging stressor positively predicted daily work engagement. Substantial time pressure impaired daily work engagement. In addition, the curvilinear relationship between daily time pressure and work engagement was attenuated as a function of increasing psychological capital or chronic sleep quality. Specifically, compared with low psychological capital or chronic sleep quality, excessive time pressure could also positively predict daily work engagement if psychological capital or chronic sleep quality was high. In addition, this study provided preliminary evidence that daily sleep quality may not be enough to buffer the curvilinear relation. Implications for research on daily work engagement and intervention programs are discussed

Charm-Quark Production in Deep-Inelastic Neutrino Scattering at Next-to-Next-to-Leading Order in QCD

We present a fully differential next-to-next-to-leading order calculation of charm-quark production in charged-current deep-inelastic scattering, with full charm-quark mass dependence. The next-to-next-to-leading order corrections in perturbative quantum chromodynamics are found to be comparable in size to the next-to-leading order corrections in certain kinematic regions. We compare our predictions with data on dimuon production in (anti)neutrino scattering from a heavy nucleus. Our results can be used to improve the extraction of the parton distribution function of a strange quark in the nucleon.National Natural Science Foundation (China) (Grant No. 11375013)National Natural Science Foundation (China) (Grant No. 11135003)United States. Dept. of Energy (Contract No. DE-AC02-06CH11357)United States. Dept. of Energy. Office of Nuclear Physics (U.S. DOE Contract No. DE-SC0011090

Mixing of X and Y states from QCD Sum Rules analysis

We study $\bar{Q}Q\bar{q}q$ and $\bar{Q}qQ\bar{q}$ states as mixed states in QCD sum rules. By calculating the two-point correlation functions of pure states of their corresponding currents, we review the mass and coupling constant predictions of $J^{PC}=1^{++}$, $1^{--}$, $1^{-+}$ states. By calculating the two-point mixed correlation functions of $\bar{Q}Q\bar{q}q$ and $\bar{Q}qQ\bar{q}$ currents, and we estimate the mass and coupling constants of the corresponding `"physical state" that couples to both $\bar{Q}Q\bar{q}q$ and $\bar{Q}qQ\bar{q}$ currents. Our results suggest that $1^{++}$ states are more likely mixing from $\bar{Q}Q\bar{q}q$ and $\bar{Q}qQ\bar{q}$ components, while for $1^{--}$ and $1^{-+}$ states, there is less mixing between $\bar{Q}Q\bar{q}q$ and $\bar{Q}qQ\bar{q}$. Our results suggest the $Y$ series of states have more complicated components.Comment: 14 pages,3 figs, 7 table

CXCL9 Is a Potential Biomarker of Immune Infiltration Associated With Favorable Prognosis in ER-Negative Breast Cancer

The chemokine CXCL9 (C-X-C motif chemokine ligand 9) has been reported to be required for antitumour immune responses following immune checkpoint blockade. In this study, we sought to investigate the potential value of CXCL9 according to immune responses in patients with breast cancer (BC). A variety of open-source databases and online tools were used to explore the expression features and prognostic significance of CXCL9 in BC and its correlation with immune-related biomarkers followed by subsequent verification with immunohistochemistry experiments. The CXCL9 mRNA level was found to be significantly higher in BC than in normal tissue and was associated with better survival outcomes in patients with ER-negative tumours. Moreover, CXCL9 is significantly correlated with immune cell infiltration and immune-related biomarkers, including CTLA4, GZMB, LAG3, PDCD1 and HAVCR2. Finally, we performed immunohistochemistry with breast cancer tissue samples and observed that CXCL9 is highly expressed in the ER-negative subgroup and positively correlated with the immune-related factors LAG3, PD1, PDL1 and CTLA4 to varying degrees. These findings suggest that CXCL9 is an underlying biomarker for predicting the status of immune infiltration in ER-negative breast cancer

Salmon Calcitonin Exerts an Antidepressant Effect by Activating Amylin Receptors

Depressive disorder is defined as a psychiatric disease characterized by the core symptoms of anhedonia and learned helplessness. Currently, the treatment of depression still calls for medications with high effectiveness, rapid action, and few side effects, although many drugs, including fluoxetine and ketamine, have been approved for clinical usage by the Food and Drug Administration (FDA). In this study, we focused on calcitonin as an amylin receptor polypeptide, of which the antidepressant effect has not been reported, even if calcitonin gene-related peptides have been previously demonstrated to improve depressive-like behaviors in rodents. Here, the antidepressant potential of salmon calcitonin (sCT) was first evaluated in a chronic restraint stress (CRS) mouse model of depression. We observed that the immobility duration in CRS mice was significantly increased during the tail suspension test and forced swimming test. Furthermore, a single administration of sCT was found to successfully rescue depressive-like behaviors in CRS mice. Lastly, AC187 as a potent amylin receptor antagonist was applied to investigate the roles of amylin receptors in depression. We found that AC187 significantly eliminated the antidepressant effects of sCT. Taken together, our data revealed that sCT could ameliorate a depressive-like phenotype probably via the amylin signaling pathway. sCT should be considered as a potential therapeutic candidate for depressive disorder in the future

A simulation study on the measurement of D0-D0bar mixing parameter y at BES-III

We established a method on measuring the \dzdzb mixing parameter $y$ for BESIII experiment at the BEPCII $e^+e^-$ collider. In this method, the doubly tagged $\psi(3770) \to D^0 \overline{D^0}$ events, with one $D$ decays to CP-eigenstates and the other $D$ decays semileptonically, are used to reconstruct the signals. Since this analysis requires good $e/\pi$ separation, a likelihood approach, which combines the $dE/dx$, time of flight and the electromagnetic shower detectors information, is used for particle identification. We estimate the sensitivity of the measurement of $y$ to be 0.007 based on a $20fb^{-1}$ fully simulated MC sample.Comment: 6 pages, 7 figure

New Perspectives on Host-Parasite Interplay by Comparative Transcriptomic and Proteomic Analyses of Schistosoma japonicum

Schistosomiasis remains a serious public health problem with an estimated 200 million people infected in 76 countries. Here we isolated ~ 8,400 potential protein-encoding cDNA contigs from Schistosoma japonicum after sequencing circa 84,000 expressed sequence tags. In tandem, we undertook a high-throughput proteomics approach to characterize the protein expression profiles of a number of developmental stages (cercariae, hepatic schistosomula, female and male adults, eggs, and miracidia) and tissues at the host-parasite interface (eggshell and tegument) by interrogating the protein database deduced from the contigs. Comparative analysis of these transcriptomic and proteomic data, the latter including 3,260 proteins with putative identities, revealed differential expression of genes among the various developmental stages and sexes of S. japonicum and localization of putative secretory and membrane antigens, enzymes, and other gene products on the adult tegument and eggshell, many of which displayed genetic polymorphisms. Numerous S. japonicum genes exhibited high levels of identity with those of their mammalian hosts, whereas many others appeared to be conserved only across the genus Schistosoma or Phylum Platyhelminthes. These findings are expected to provide new insights into the pathophysiology of schistosomiasis and for the development of improved interventions for disease control and will facilitate a more fundamental understanding of schistosome biology, evolution, and the host-parasite interplay