44 research outputs found

    Potential Application of Copper Aspirinate in Preventing and Treating Thromboembolic Diseases

    Get PDF
    The efficacy of copper aspirinate against thrombotic diseases has been tested in animal models. The results show that copper aspirinate, following ig pretreatment for 7 days at 0.012mmol/kg markedly prolonged the bleeding time and inhibited the mortality induced by arachidonic acid (AA) in mice. On cereral ischemia model pretreatment with 0.018mmol/kg copper aspirinate ig significantly increased survival of animals and the density of intact hippocampal CA1 cells and decreased brain calcium concentration. Its anticerebral ischemia activity was superior to or equal to nimodipine. It is, therefore, suggested that copper aspirinate is very promising in becoming an antithrombotic drug in preventing and treating thrombotic diseases

    Cerebroprotective Effects of Dimeric Copper(II) Bis(o-acetoxybenzoate) on Ischemia-reperfusion Injury in Gerbils

    Get PDF
    The cerebroprotective effects of copper aspirinate [dimeric copper(II) bis(o-acetoxybenzoate)] were investigated in gerbils subjected to 10-min global cerebral ischemia followed b 60-min reperfusion. The results showed that intragastric copper aspirinate (7.5, 15.0 and 30.0 mg Kg−1) markedly promoted the recovery of the electroencephalogram amplitude, attenuated the increase of lipid peroxide content and the decrease of superoxide dismutase activity in the cortex during ischemia-reperfusion injury. It suggested that copper aspirinate possesses potential neuroprotective properties, the mechanism of which might be related to an increase of the activity of endogenous superoxide dismutase

    Topological Magnetoresistance of Magnetic Skyrmionic Bubbles

    Full text link
    Magnetic skyrmions offer promising prospects for constructing future energy-efficient and high-density information technology, leading to extensive explorations of new skyrmionic materials recently. The topological Hall effect has been widely adopted as a distinctive marker of skyrmion emergence. Alternately, here we propose a novel signature of skyrmion state by quantitatively investigating the magnetoresistance (MR) induced by skyrmionic bubbles in CeMn2Ge2. An intriguing finding was revealed: the anomalous MR measured at different temperatures can be normalized into a single curve, regardless of sample thickness. This behavior can be accurately reproduced by the recent chiral spin textures MR model. Further analysis of the MR anomaly allowed us to quantitatively examine the effective magnetic fields of various scattering channels. Remarkably, the analyses, combined with the Lorentz transmission electronic microscopy results, indicate that the in-plane scattering channel with triplet exchange interactions predominantly governs the magnetotransport in the Bloch-type skyrmionic bubble state. Our results not only provide insights into the quantum correction on MR induced by skyrmionic bubble phase, but also present an electrical probing method for studying chiral spin texture formation, evolution and their topological properties, which opens up exciting possibilities for identifying new skyrmionic materials and advancing the methodology for studying chiral spin textures.Comment: 17 pages,5 figures,submitte

    Age-associated microbiome shows the giant panda lives on hemicelluloses, not on cellulose

    Get PDF
    The giant panda feeds almost exclusively on bamboo, a diet highly enriched in lignin and cellulose, but is characterized by a digestive tract similar to carnivores. It is still large unknown if and how the giant panda gut microbiota contributes to lignin and cellulose degradation. Here we show the giant pandas’ gut microbiota does not significantly contribute to cellulose and lignin degradation. We found that no operational taxonomic unit had a nearest neighbor identified as a cellulolytic species or strain with a significant higher abundance in juvenile than cubs, a very low abundance of putative lignin and cellulose genes existed in part of analyzing samples but a significant higher abundance of genes involved in starch and hemicellulose degradation in juveniles than cubs. Moreover, a significant lower abundance of putative cellulolytic genes and a significant higher abundance of putative α-amylase and hemicellulase gene families were present in giant pandas than in omnivores or herbivores

    Wake Bifurcations Behind Two Circular Disks in Tandem arrangement

    Get PDF
    The wake bifurcations behind two circular disks in tandem arrangement are investigated through numerical simulations. The separation distance between the disks, S/d, is chosen at 1, 2, 4, and 6, and the Reynolds number, Re, lies in the range of 100 Re 500. The wake dynamics are examined in terms of the flow structures as well as drag and lift coefficient characteristics. Seven main wake regimes are observed in the considered (Re, S/d) space: steady state (SS), Zig-zig (Zz) mode, standing wave mode, periodic state with reflectional symmetry breaking (RSB), periodic state with double-helical (DH) structures shedding, periodic state with double-hairpin-loop (DHL) shedding, and weakly chaotic state. Among these bifurcations, the DH and DHL wake modes are reported in the tandem disk wakes, which are not observed in a single disk wake. Compared with the single disk wake, the first bifurcation leading to the SS mode is always delayed in tandem configuration, which is especially evident for the case of S/d = 1. For the second bifurcation leading to an unsteady state, some differences lie in the wake mode for different tandem configurations. The second bifurcation leads to the Zz wake mode for the cases S/d = 1, 2, and 4, and the RSB mode for S/d = 6. In the scenario of S/d = 1, the bifurcations are similar to those of a thick disk, suggesting that a shorter separation distance in this configuration has equivalent effects as increasing the thickness in the case of a single disk. In the scenario of S/d = 2, the bifurcations are complex and quite different from those in a single disk wake, indicating that the interaction between two disks in tandem arrangement is stronger when the trailing disk is located close to the end of the recirculation
    corecore