Tetra­kis(μ-2-phen­oxy­propionato)-κ3 O,O′:O′;κ3 O:O,O′,κ4 O:O′-bis­[(1,10-phenanthroline-κ2 N,N′)(2-phen­oxy­propionato-κ2 O,O′)praseodymium(III)]

In the centrosymmetric binuclear title complex, [Pr2(C9H9O3)6(C12H8N2)2], the two PrIII ions are linked by four 2-phen­oxy­propionate (L) groups through their bi- and tridentate bridging modes. Each PrIII ion is nine-coordinated by one 1,10-phenanthroline mol­ecule, one bidentate carboxyl­ate group and four bridging carboxyl­ate groups in a distorted PrN2O7 monocapped square-anti­prismatic geometry. The title compound is isotypic with its terbium- and dysprosium-containing analogues

Tetra­kis(μ2-2-phen­oxy­propionato)-κ3 O,O′:O′;κ3 O:O,O′;κ4 O:O′-bis­[(1,10-phenanthroline-κ2 N,N′)(2-phen­oxy­propionato-κ2 O,O′)lanthanum(III)]

In the centrosymmetric binuclear title complex, [La2(C9H9O3)6(C12H8N2)2], the two La(III) ions are linked by four 2-phen­oxy­propionate (L) groups in bi- and tridentate bridging modes. Each LaIII ion is nine-coordinated by one 1,10-phenanthroline mol­ecule, one bidentate chelating carboxyl­ate group and four bridging carboxyl­ate groups in a distorted LaN2O7 monocapped square-anti­prismatic geometry

Bis(μ2-2-phen­oxy­propionato-κ2 O:O′)bis­[(1,10-phenanthroline-κ2 N,N′)bis­(2-phen­oxy­propionato-κ2 O,O′)ytterbium(III)]

In the centrosymmetric binuclear title complex, [Yb2(C9H9O3)6(C12H8N2)2], the two Yb(III) ions are linked by two 2-phen­oxy­propionate (L) groups in a bidentate bridging mode. Each YbIII ion is eight-coordinated by two O atoms from two bridging L ligands, four O atoms from two chelating L groups and two N atoms from one chelating phen mol­ecule in a distorted YbN2O6 dodeca­hedral geometry

Tetra­kis(μ-2-phen­oxy­propionato)-κ3 O,O′:O′;κ3 O:O,O′,κ4 O:O′-bis­[(1,10-phenanthroline-κ2 N,N′)(2-phen­oxy­propionato-κ2 O,O′)dysprosium(III)]

In the centrosymmetric binuclear title complex, [Dy2(C9H9O3)6(C12H8N2)2], the two DyIII ions are linked by four 2-phen­oxy­propionate (L) groups through their bi- and tridentate bridging modes. Each DyIII ion is nine-coordinated by one 1,10-phenanthroline mol­ecule, one bidentate carboxyl­ate group and four bridging carboxyl­ate groups in a distorted DyN2O7 monocapped square-anti­prismatic geometry. The title compound is isotypic with its terbium-containing analogue

Structure of human tryptophanyl-tRNA synthetase in complex with tRNA(Trp) reveals the molecular basis of tRNA recognition and specificity

Aminoacyl-tRNA synthetases (aaRSs) are a family of enzymes responsible for the covalent link of amino acids to their cognate tRNAs. The selectivity and species-specificity in the recognitions of both amino acid and tRNA by aaRSs play a vital role in maintaining the fidelity of protein synthesis. We report here the first crystal structure of human tryptophanyl-tRNA synthetase (hTrpRS) in complex with tRNA(Trp) and Trp which, together with biochemical data, reveals the molecular basis of a novel tRNA binding and recognition mechanism. hTrpRS recognizes the tRNA acceptor arm from the major groove; however, the 3′ end CCA of the tRNA makes a sharp turn to bind at the active site with a deformed conformation. The discriminator base A73 is specifically recognized by an α-helix of the unique N-terminal domain and the anticodon loop by an α-helix insertion of the C-terminal domain. The N-terminal domain appears to be involved in Trp activation, but not essential for tRNA binding and acylation. Structural and sequence comparisons suggest that this novel tRNA binding and recognition mechanism is very likely shared by other archaeal and eukaryotic TrpRSs, but not by bacterial TrpRSs. Our findings provide insights into the molecular basis of tRNA specificity and species-specificity

Triaqua­bis­{2-meth­oxy-6-[(phenyl­iminium­yl)meth­yl]phenolate-κO 1}manganese(II) dinitrate

The crystal structure of the title compound, [Mn(C14H13NO2)2(H2O)3](NO3)2, is comprised of two Schiff base 2-meth­oxy-6-(N-phenyl­carboximido­yl)phenol (HL) ligands and three coordinated water mol­ecules. The MnII ion lies on a twofold axis that bis­ects one water O atom. The coordination sphere of the five-coordinate Mn atom is completed by the two monodentate HL ligands and three coordinated water mol­ecules binding through their O atoms, affording a distorted tetra­gonal–pyramidal geometry. In the phenolate ligands, the hy­droxy H atom transfers to the imine N atom. This H atom is also involved in an intra­molecular N—H⋯O hydrogen bond that imposes a nearly planar conformation on each ligand, with dihedral angles of 2.78 (3) and 2.43 (5)° between the aromatic rings of each ligand. In the crystal, mol­ecules are linked by inter­molecular O—H⋯O hydrogen bonds

Tris{2-meth­oxy-6-[(4-methyl­phen­yl)iminiometh­yl]phenolate-κ2 O,O′}tris­(thio­cyanato-κN)lanthanum(III)

In the title compound, [La(NCS)3(C15H15NO2)3], the metal centre is nine-coordinated by six O atoms from three zwitterionic Schiff base 2-meth­oxy-6-[(4-methyl­phen­yl)iminio­meth­yl]phenolate (L) ligands and three terminal N atoms of the thio­cyanate ions in a monocapped square-anti­prismatic environment. The L ligands chelate the LaIII ion with strong La—O(deprotonated phenolic) bonds [2.435 (3)–2.464 (3) Å] and significantly longer La—O(meth­oxy) bonds [2.801 (3)–2.831 (3) Å]. The La—N bond lengths range from 2.541 (4) to 2.605 (4) Å

catena-Poly[[[bis­(3-hy­droxy­adamantane-1-carboxyl­ato-κO 1)(3-hy­droxy­adamantane-1-carb­oxy­lic acid-κO 1)zinc(II)]-μ2-4,4′-bipyridine] monohydrate]

In the title coordination polymer, {[Zn(C11H15O3)2(C10H8N2)(C11H16O3)]·H2O}n, the ZnII ion is five coordinated by two N atoms from two 4,4′-bipyridine (4,4′-bpy) mol­ecules and three O atoms from two 3-hy­droxy­adamantane-1-carboxyl­ate anions (L) and one 3-hy­droxy­adamantane-1-carb­oxy­lic acid (HL) mol­ecule. The resulting coordination polyhedron is a near regular ZnN2O3 trigonal bipyramid, with the N atoms in axial sites. The 4,4′-bpy mol­ecules [dihedral angle between the aromatic rings = 17.2 (2)°] act as bridges, connecting the metal ions into an infinite polymeric chain propagating in [01]. O—H⋯O hydrogen bonds help to consolidate the packing

2-Phenyl-1,3-selenazole-4-carb­oxy­lic acid

In the title compound, C10H7NO2Se, the two rings are twisted, making a dihedral angle of 12.42 (9)°. In the crystal, pairs of mol­ecules are disposed about an inversion center, generating O—H⋯O hydrogen-bonded dimers

Tris(1,10-phenanthroline-κ2 N,N′)zinc(II) chloride 2-phenyl-4-selenazole-5-car­box­yl­ate decahydrate

The asymmetric unit of the title salt, [Zn(C12H8N2)3](C10H6NO2Se)Cl·10H2O, contains a [Zn(phen)3]2+ cation (phen is 1,10-phenanthroline), uncoordinated chloride and 2-phenyl-4-selenazole-5-carboxyl­ate anions and ten uncoord­in­ated water mol­ecules. The central ZnII ion is six-coordinated by six N atoms from three phen ligands in a distorted octa­hedral geometry. An extensive O—H⋯O, O—H⋯N and O—H⋯Cl hydrogen-bonding network stabilizes the crystal structure