Equality Delayed is Equality Denied for Indigenous Women

Ce texte se veut une courte histoire du sexisme présent dans la législation canadienne qui touche le peuple autochtone dans la Loi des Indiens. Depuis son élection en 1876, en dépit des nombreux amendements qui ont suivi, les femmes autochtones n’ont jamais été reconnues comme telles. Elles furent traitées comme citoyennes de seconde classe, moins que des parents, encore moins comme Indiennes. Les auteures sont d’avis que cette loi discriminatoire a grandement contribué au sérieux problème des femmes autochtones perdues et assassinées au Canada. Cet article demande au Gouvernement de cesser ses sursis et de finalement agir vers un changement

Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia.

The occurrence of non-epileptic hyperkinetic movements in the context of developmental epileptic encephalopathies is an increasingly recognized phenomenon. Identification of causative mutations provides an important insight into common pathogenic mechanisms that cause both seizures and abnormal motor control. We report bi-allelic loss-of-function CACNA1B variants in six children from three unrelated families whose affected members present with a complex and progressive neurological syndrome. All affected individuals presented with epileptic encephalopathy, severe neurodevelopmental delay (often with regression), and a hyperkinetic movement disorder. Additional neurological features included postnatal microcephaly and hypotonia. Five children died in childhood or adolescence (mean age of death: 9 years), mainly as a result of secondary respiratory complications. CACNA1B encodes the pore-forming subunit of the pre-synaptic neuronal voltage-gated calcium channel Cav2.2/N-type, crucial for SNARE-mediated neurotransmission, particularly in the early postnatal period. Bi-allelic loss-of-function variants in CACNA1B are predicted to cause disruption of Ca2+ influx, leading to impaired synaptic neurotransmission. The resultant effect on neuronal function is likely to be important in the development of involuntary movements and epilepsy. Overall, our findings provide further evidence for the key role of Cav2.2 in normal human neurodevelopment.MAK is funded by an NIHR Research Professorship and receives funding from the Wellcome Trust, Great Ormond Street Children's Hospital Charity, and Rosetrees Trust. E.M. received funding from the Rosetrees Trust (CD-A53) and Great Ormond Street Hospital Children's Charity. K.G. received funding from Temple Street Foundation. A.M. is funded by Great Ormond Street Hospital, the National Institute for Health Research (NIHR), and Biomedical Research Centre. F.L.R. and D.G. are funded by Cambridge Biomedical Research Centre. K.C. and A.S.J. are funded by NIHR Bioresource for Rare Diseases. The DDD Study presents independent research commissioned by the Health Innovation Challenge Fund (grant number HICF-1009-003), a parallel funding partnership between the Wellcome Trust and the Department of Health, and the Wellcome Trust Sanger Institute (grant number WT098051). We acknowledge support from the UK Department of Health via the NIHR comprehensive Biomedical Research Centre award to Guy's and St. Thomas' National Health Service (NHS) Foundation Trust in partnership with King's College London. This research was also supported by the NIHR Great Ormond Street Hospital Biomedical Research Centre. J.H.C. is in receipt of an NIHR Senior Investigator Award. The research team acknowledges the support of the NIHR through the Comprehensive Clinical Research Network. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, Department of Health, or Wellcome Trust. E.R.M. acknowledges support from NIHR Cambridge Biomedical Research Centre, an NIHR Senior Investigator Award, and the University of Cambridge has received salary support in respect of E.R.M. from the NHS in the East of England through the Clinical Academic Reserve. I.E.S. is supported by the National Health and Medical Research Council of Australia (Program Grant and Practitioner Fellowship)

Equal Status for Indigenous Women— Sometime, Not Now : The Indian Act and Bill S-3

Cet article interpelle la législation canadienne discriminatoire qui frappe le peuple autochtone, spécialement les femmes. Les jeunes filles sont particulièrement vulnérables et il a été prouvé qu’elles sont à la racine de cette culture de la violence contre elles. En dépit de cette réalité, l’auteure accuse le Gouvernementqui n’a jamais pris des mesures pour éradiquer ce point névralgique dans cette loi qui continue à refuser aux femmes et jeunes filles le statut qui leur est dû. Cet articledemande que la loi 3 ou 6(1A) se propose d’amender cette loi qui perpétue la discrimination sexuelle