Using machine learning for intelligent shard sizing on the cloud

Sharding implementations use conservative approximations for determining the number of cloud instances required and the size of the shards to be stored on each of them. Conservative approximations are often inaccurate and result in overloaded deployments, which need reactive refinement. Reactive refinement results in demand for additional resources from an already overloaded system and is counterproductive. This paper proposes an algorithm that eliminates the need for conservative approximations and reduces the need for reactive refinement. A multiple linear regression based machine learning algorithm is used to predict the latency of requests for a given application deployed on a cloud machine. The predicted latency helps to decide accurately and with certainty if the capacity of the cloud machine will satisfy the service level agreement for effective operation of the application. Application of the proposed methods on a popular database schema on the cloud resulted in highly accurate predictions. The results of the deployment and the tests performed to establish the accuracy have been presented in detail and are shown to establish the authenticity of the claims

Efficient read monotonic data aggregation across shards on the cloud

Client-centric consistency models define the view of the data storage expected by a client in relation to the operations done by a client within a session. Monotonic reads is a client-centric consistency model which ensures that if a process has seen a particular value for the object, any subsequent accesses will never return any previous values. Monotonic reads are used in several applications like news feeds and social networks to ensure that the user always has a forward moving view of the data. The idea of Monotonic reads over multiple copies of the data and for lightly loaded systems is intuitive and easy to implement. For example, ensuring that a client session always fetches data from the same server automatically ensures that the user will never view old data. However, such a simplistic setup will not work for large deployments on the cloud, where the data is sharded across multiple high availability setups and there are several million clients accessing data at the same time. In such a setup it becomes necessary to ensure that the data fetched from multiple shards are logically consistent with each other. The use of trivial implementations, like sticky sessions, causes severe performance degradation during peak loads. This paper explores the challenges surrounding consistent monotonic reads over a sharded setup on the cloud and proposes an efficient architecture for the same. Performance of the proposed architecture is measured by implementing it on a cloud setup and measuring the response times for different shard counts. We show that the proposed solution scales with almost no change in performance as the number of shards increases

Neuroprotective Activity of Evolvulus alsinoides & Centella asiatica Ethanolic Extracts in Scopolamine-Induced Amnesia in Swiss Albino Mice

AIM: To carry out the comparative nootropic, neuroprotective potentials of two medicinal plant species. MATERIAL AND METHODS: For neuroprotective activity; behavior models (elevated plus maze & morris water maze), in vivo antioxidant (superoxide dismutase, catalase, lipid peroxidation & reduced glutathione), inflammatory markers (IL-1β, IL-6 & TNF-α) and acetylcholine esterase (AChE) assessment procedures followed at different dosages i.e. 250 & 500 mg/kg of Evolvulus alsinoides and Centella asiatica ethanolic extracts. At the end of the study, it was performed histopathological analysis of the following organs: brain, heart, liver, and kidney. RESULTS: In oral administration of different doses of ethanolic extracts of both medicinal plants i.e. Sco + EEA 250 = 2.49 ± 0.29 , Sco + EEA 500 = 2.67 ± 0.36, Sco + ECA 250 = 2.33 ± 0.17, Sco + ECA 500 = 2.77 ± 0.21, Sco + EEA + ECA 250 = 2.61 ± 0.32 and Sco + EEA + ECA 500 = 2.79 ± 0.16 U/mg of protein respectively against the scopolamine induced group Sco (control) = 5.51 ± 0.35 U/mg of protein extracts shows neuroprotective and nootropic activity with reducing AChE level in the brain homogenate of swiss albino mice. CONCLUSION: Since the E. alsinoides & C. asiatica are already used in traditional Indian medicine as the neuroprotective agent and also found promising effects over inflammatory diseases, wound healing, and immunomodulatory activity. The neuroprotective effect of both plants extracts attributed to inhibition of AChE activity and improve the spatial memory formation

In Vivo Toxicity Study of Ethanolic Extracts of Evolvulus alsinoides & Centella asiatica in Swiss Albino Mice

AIM: We aimed to investigate several parameters after the in vivo acute and sub-acute administration of ethanolic extracts from E. alsinoides & C. asiatica. METHODS: Malignant Ovarian Germ Cell Tumors for in vivo toxicity study guidelines 423 and 407 of Organization for Economic Co-operation and Development (OECD) were followed for acute and sub-acute toxicity assays respectively. For LD50 evaluation, a single dose of ethanolic extracts of Evolvulus alsinoides L. (EEA) and ethanolic extracts of Centella asiatica (ECA) was orally administered to mice at doses of 200, 400, 800, 1600 and 2000 mg/kg. Then the animals were observed for 72 hours. For acute toxicity evaluation, a single dose of both extracts was orally administered to mice at doses of 300, 600, 1200 and 2000 mg/kg and the animals were observed for 14 days. In the sub-acute study, the extracts were orally administered to mice for 28 days at doses of 300, 600, 1200 and 2000 mg/kg. To assess the toxicological effects, animals were closely observed on general behaviour, clinical signs of toxicity, body weight, food and water intake. At the end of the study, it was performed biochemical and hematological evaluations, as well as histopathological analysis from the following organs: brain, heart, liver, and kidney. RESULTS: The oral administration of E. alsinoides and C. asiatica ethanolic extracts, i.e. EEA 300, EEA 600, EEA 1200, EEA 2000, ECA 300, ECA 600, ECA 1200 & ECA 2000 mg/kg doses showed no moral toxicity effect in LD50, acute and sub-acute toxicity parameters. CONCLUSION: In this study, we had found that E. alsinoides & C. asiatica extract at different doses cause no mortality in acute and sub-acute toxicity study. Also, histopathology of kidney, liver, heart, and brain showed no alterations in tissues morphology

International Journal of Advance Research and Innovation Antitheft System in Vehicle with Automatic Headlights

Abstract Now a day's we see that vehicles stolen are on the rise and police has registered so many cases of vehicle stolen every day. Ironically, most of the stolen vehicles are not recovered. Hence it has become a serious issue over years. Besides this world has facing a very serious problem due to accidents of vehicles on roads, it causes loss of life and property. Therefore I have come up with a concept of developing a wireless technology based vehicle theft information system to provide security to vehicles from theft. In this concept if someone tries to steal the vehicle then a SMS is send to the owner mobile through GSM technology that your vehicle has been stolen. An added advantage of this system is that the owner can disable the ignition of the vehicle and prevent theft of the vehicle. Also it protects the vehicle from accidents due to glare of eyes of driver by high beam headlights on roads. Since this system contain automatic head light system which can automatically judge when the headlight beam needs to be lowered when some vehicle approaching in front of our vehicle and prevent accidents

Morphometric analysis of posterior cranial fossa and foramen magnum and it’s clinical implications in craniovertebral junction malformations: a computed tomography based institutional study in a tertiary care hospital of northern part of India

Abstract Background The posterior cranial fossa (PCF) and the foramen magnum (FM) are the critical anatomical components of the craniovertebral junction region, which comprise and transmit numerous vital neurovascular structures. So, a fundamental knowledge of the basic radiological anatomy of PCF and FM is of paramount importance in the evaluation of associated pathologies and approaching these areas surgically. The aim of this study is to describe different linear and angular craniometric parameters of PCF, FM and surrounding territory based on reconstructed computed tomography (CT) images. Material and methods This study was conducted in our tertiary care hospital in northern India from the period of January 2023 to June 2023 on 120 patients, and CT screening was done for the head and spine region following a history of head injury. Results In this study, 120 patients were included, of whom 50.83% (n = 61) were females and 49.17% (n = 59) were males. Age ranged from 18 to 70 years with mean age of 43.5 ± 14.08 years. The mean values for linear craniometric parameters of PCF were statistically nonsignificant for different age groups. Statistically significant differences were found for twinning line (TL) (p < 0.0001), McRae’s line (< 0.0001), clivus length (< p < 0.0001), internal occipital protuberence -opisthion line (p = 0.01), Klaus’ index (p < 0.0001), height of posterior fossa (h) (p < 0.0001), h/TL (p = 0.028), when these values were compared for the genders. The measurements of FM transverse diameter, anteroposterior diameter and area were 27.12 ± 1.42 mm (range 23.6–30.1 mm), 30.99 ± 2.23 mm (range 27.6–35.8 mm) and 691.32 ± 30.35 mm2 (range 632.7–777.7 mm2). The values of clivus canal angle (p = 0.038) and clivoodontoid angle (p = 0.012) were statistically significant when compared for different age groups. The values of Boogard’s angle (p = 0.021) and tentorial slope (p = 0.031) were statistically significant when these were compared for the genders. Conclusions This study described almost all the linear and angular craniometric parameters used in the morphometric analysis of PCF and FM. The findings of this study provide valuable data regarding linear and angular craniometric parameters of PCF and FM which can redefine reference values

Occurrence of Superconductivity and Magnetism in Nominally Undoped LaOFeAs

Superconductivity in a LaOFeAs system is known to get introduced by F-doping (LaO1−xFxFeAs) even under ambient conditions and oxygen deficiency (LaO1−xFeAs)under high pressure conditions. Hitherto unreported, superconductivity in F-free undoped LaOFeAs samples is observed and confirmed for the first time by various characterization tools–resistive ρ(T,B), magnetic M(T,B) and modulated microwave absorption (MMA) measurements. The ρ(T ) at B = 0 shows a clear superconducting transition with an onset at Tcon ∼ 17 K and a tail-like behavior when R goes to zero at Tc0 ∼ 8 K. In the presence of B, the superconducting transition shifts to lower T with a rate ∼−5.5 and −1.65 T/K, depending on whether the ρ(T ) has dropped to 90% or 5% of its normal state value, respectively. M(T ) in zero field cooling at B = 10 mT shows diamagnetic downturn below at ∼12 K. At T Tc0, indicating the presence of weak link superconducting networks in the sample. The sample shows a complex electrical and magnetic behavior in the normal state. For instance, ρ(T ) reveals a weak SDW-like anomaly at T ∼ 132 K along with a resistivity minimum at Tmin ∼ 78 K. M(T ) also shows the presence of a magnetic anomaly at T ∼ 130 K. Both below and above Tcon, presence of an additional ferromagnetic component is observed in the isothermal M(B) loop measurements. The superconducting and normal state features of our sample are compared with other undoped and doped LaOFeAs systems reported in the literature

Dependence of Superconductivity and Its Weakly Linked Behavior in Bulk LaO1-xFx FeAs on F Doping

Samples of oxypnictide compound LaO1-x F (x) FeAs, with x=0.15 and 0.2 corresponding to over- and highly over-doped compositions, respectively, were prepared by solid-state reaction. We present their characterization by XRD and HRTEM, as well as resistivity rho(T), magnetization M(B) and microwave modulated absorption (MMA) response between 4.2-300 K and applied fields B=0-8 T. With change in x, both the superconducting and magnetic behavior of the samples shows an interesting pattern. The "magnetic anomaly" at T similar to 130 K, observed in M(T) for x=0, instead of getting totally suppressed shows a tendency to reappear in x=0.2 sample. Both samples typically show rho(300 K)> 2.8x10(-3) Omega cm and critical current density J (c)(5 K, 1 T)< 2x10(7) A/m(2). The superconducting transitions as measured by rho(T) at B=0 are found broad for both x=0.15 and 0.2 samples with transition widths similar to 2.5 and 6 K, respectively. The slope |dB (c2)/dT| (where B (c2) is upper critical field) determined by resistive onsets, for the x=0.15 and 0.2 samples, has values similar to 7.5 and 3.5 T/K, respectively. The superconducting state characteristics as reflected by rho(T,B), M(T), magnetic J (c)(B) and MMA response are typical of the presence of weakly linked inter-grain regions in both the samples. Our HRTEM images of the x=0.15 sample show the presence of high angle (similar to 43(a similar to)) grain boundaries, which are well known to limit the J (c) in cuprate-based high T (c) bulk materials