124 research outputs found
Early replication in pulmonary B cells after infection with marek's disease herpesvirus by the respiratory route
Natural infection with Marek's disease virus occurs through the respiratory mucosa after chickens inhale dander shed from infected chickens. The early events in the lung following exposure to the feather and squamous epithelial cell debris containing the viral particles remain unclear. In order to elucidate the virological and immunological consequences of MDV infection for the respiratory tract, chickens were infected by intratracheal administration of infective dander. Differences between susceptible and resistant chickens were immediately apparent, with delayed viral replication and earlier onset of interferon (IFN)-γ production in the latter. CD4+ and CD8 + T cells surrounded infected cells in the lung. Although viral replication was evident in macrophages, pulmonary B cells were the main target cell type in susceptible chickens following intratracheal infection with MDV. In accordance, depletion of B cells curtailed viremia and substantially affected pathogenesis in susceptible chickens. Together the data described here demonstrate the role of pulmonary B cells as the primary and predominant target cells and their importance for MDV pathogenesis. © 2009, Mary Ann Liebert, Inc.
Food allergy in Asia
10.1097/01.all.0000225160.52650.17Current Opinion in Allergy and Clinical Immunology63197-20
Prevention of food allergy in the real life
Asian Pacific Journal of Allergy and Immunology32116 - 24APJI
Ant allergy in Asia and Australia
10.1097/01.all.0000136761.51195.01Current Opinion in Allergy and Clinical Immunology44325-328COAC
Allergies in Asia: Differences in prevalence and management compared with Western populations
10.1586/eci.09.82Expert Review of Clinical Immunology62279-28
Effects of Migration on Allergic Diseases
10.1159/000494129International Archives of Allergy and Immunology1782128 - 140IAAI
Food-dependent exercise-induced anaphylaxis - A review of 5 cases
Annals of the Academy of Medicine Singapore3810905-90
Thalidomide responsiveness in an infant with Behcet's syndrome
10.1542/peds.103.6.1295Pediatrics1036 I1295-1297PEDI
Prevalence of asthma and comorbid allergy symptoms in Singaporean preschoolers
Asian Pacific Journal of Allergy and Immunology244175-18
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