83 research outputs found
Early replication in pulmonary B cells after infection with marek's disease herpesvirus by the respiratory route
Natural infection with Marek's disease virus occurs through the respiratory mucosa after chickens inhale dander shed from infected chickens. The early events in the lung following exposure to the feather and squamous epithelial cell debris containing the viral particles remain unclear. In order to elucidate the virological and immunological consequences of MDV infection for the respiratory tract, chickens were infected by intratracheal administration of infective dander. Differences between susceptible and resistant chickens were immediately apparent, with delayed viral replication and earlier onset of interferon (IFN)-γ production in the latter. CD4+ and CD8 + T cells surrounded infected cells in the lung. Although viral replication was evident in macrophages, pulmonary B cells were the main target cell type in susceptible chickens following intratracheal infection with MDV. In accordance, depletion of B cells curtailed viremia and substantially affected pathogenesis in susceptible chickens. Together the data described here demonstrate the role of pulmonary B cells as the primary and predominant target cells and their importance for MDV pathogenesis. © 2009, Mary Ann Liebert, Inc.
Food allergy in Asia
10.1097/01.all.0000225160.52650.17Current Opinion in Allergy and Clinical Immunology63197-20
Ant allergy in Asia and Australia
10.1097/01.all.0000136761.51195.01Current Opinion in Allergy and Clinical Immunology44325-328COAC
Effects of Migration on Allergic Diseases
10.1159/000494129International Archives of Allergy and Immunology1782128 - 140IAAI
Thalidomide responsiveness in an infant with Behcet's syndrome
10.1542/peds.103.6.1295Pediatrics1036 I1295-1297PEDI
Molecular cloning of Blomia tropicalis allergens - A major source of dust mite allergens in the tropics and subtropics
10.2174/187152806779010954Inflammation and Allergy - Drug Targets54261-26
Genetic susceptibility to asthma and atopy among Chinese in Singapore - Linkage to markers on chromosome 5q31-33
10.1034/j.1398-9995.2001.056008749.xAllergy: European Journal of Allergy and Clinical Immunology568749-753LLRG
Missing parvalbumin: Implications in diagnostic testing for tuna allergy [3]
10.1016/j.jaci.2004.12.1117Journal of Allergy and Clinical Immunology1154874-875JACI
Molecular analysis of infant fecal microbiota in an Asian at-risk cohort-correlates with infant and childhood eczema
10.1186/1756-0500-7-166BMC Research Notes7116
Stem cell transplantation for primary immunodeficiency disease: Experience of a singapore hospital
10.1097/WOX.0b013e31824af5e3World Allergy Organization Journal5341-4
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