Study to Find Hemodynamic Changes and Complications Occurring with Propofol and Etomidate During General Anaesthesia: A Tertiary Care Institutional Based Study

Background: Among general anesthesia induction drugs, etomidate is the only imidazole, and it has the most favourable therapeutic index for single bolus administration. Propofol is non-barbiturate short acting intravenous anaesthetic agent. It is a phenol derivative (2,6-Diisopropylphenol). Hence; the present study was undertaken for assessing the hemodynamic changes and complication occurring with propofol and etomidate during general anaesthesia. Materials & Methods: A total of 40 patients scheduled to undergo surgical procedure under general anesthesia were enrolled. All the patients were divided broadly into two study groups with 20 patients in each group as follows: Group 1: Propofol group, and Group 2: Etomidate group. Propofol group received propofol at 2 mg/kg and etomidate group received etomidate at 0.2 mg/kg. Pain on injection and myoclonic movements were recorded, if any at induction. As soon as the onset of unconsciousness occurs consumed dose of anaesthetic were recorded individually. All the results were recorded and analysed by SPSS software. Results: Mean heart rate among patients of group 1 at baseline, at induction and at 10 minutes was 85.6, 98.4 and 81.3 respectively. Mean heart rate among patients of group 2 at baseline, at induction and at 10 minutes was 84.2, 96.1 and 82.7 respectively. Mean arterial pressure among patients of group 1 at baseline, at induction and at 10 minutes was 89.3, 80.4 and 94.6 respectively. Mean arterial pressure among patients of group 2 at baseline, at induction and at 10 minutes was 90.1, 88.6 and 95.4 respectively. Significant results were obtained while comparing the mean arterial pressure at induction among the two study groups. Pain on injection was seen in 2 patients of group 1 and 1 patient of group 2. Conclusion: From the above results, the authors concluded that etomidate was better in comparison to propofol during general anaesthesia