Pamela: development of the RF system for a non-relativistic non-scaling FFAG

The PAMELA project(Particle Accelerator For MEdical Applications) currently consists of the design of a particle therapy facility. The project, which is in the design phase, contains Non-Scaling FFAG, particle accelerator capable of rapid beam acceleration, giving a pulse repetition rate of 1kHz, far beyond that of a conventional synchrotron. To realise the repetition rate, a key component of the accelerator is the rf accelerating system. The combination of a high energy gain per turn and a high repetition rate is a significant challenge. In this paper, options for the rf system of the proton ring and the status of development are presented

Two different quasiparticle scattering rates in vortex line liquid phase of layered d-wave superconductors

We carry out a quantum mechanical analysis of the behavior of nodal quasiparticles in the vortex line liquid phase of planar d-wave superconductors. Applying a novel path integral technique we calculate a number of experimentally relevant observables and demonstrate that in the low-field regime the quasiparticle scattering rates deduced from photoemission and thermal transport data can be markedly different from that extracted from tunneling, specific heat, superfluid stiffness or spin-lattice relaxation time.Comment: Latex, 4 pages, no figure

Competing orders in a magnetic field: spin and charge order in the cuprate superconductors

We describe two-dimensional quantum spin fluctuations in a superconducting Abrikosov flux lattice induced by a magnetic field applied to a doped Mott insulator. Complete numerical solutions of a self-consistent large N theory provide detailed information on the phase diagram and on the spatial structure of the dynamic spin spectrum. Our results apply to phases with and without long-range spin density wave order and to the magnetic quantum critical point separating these phases. We discuss the relationship of our results to a number of recent neutron scattering measurements on the cuprate superconductors in the presence of an applied field. We compute the pinning of static charge order by the vortex cores in the `spin gap' phase where the spin order remains dynamically fluctuating, and argue that these results apply to recent scanning tunnelling microscopy (STM) measurements. We show that with a single typical set of values for the coupling constants, our model describes the field dependence of the elastic neutron scattering intensities, the absence of satellite Bragg peaks associated with the vortex lattice in existing neutron scattering observations, and the spatial extent of charge order in STM observations. We mention implications of our theory for NMR experiments. We also present a theoretical discussion of more exotic states that can be built out of the spin and charge order parameters, including spin nematics and phases with `exciton fractionalization'.Comment: 36 pages, 33 figures; for a popular introduction, see http://onsager.physics.yale.edu/superflow.html; (v2) Added reference to new work of Chen and Ting; (v3) reorganized presentation for improved clarity, and added new appendix on microscopic origin; (v4) final published version with minor change

Activation of ion channels in tumor cells by leukoregulin, a cytostatic lymphokin

We used the whole-cell patch-clamp recording technique to study the effects of leukoregulin (LR), a cytostatic lymphokine produced by activated human peripheral blood lymphocytes, on the electrical properties of K562 tumor cells. LR induced changes in the membrane excitability in 33 of 55 cells studied. A minute or more after application, LR elicited a complex and reversible electrical response. The response lasted for several more minutes in the continued presence of LR. It consisted of (a) moderate-conductance (50 pS), cation-selective, ion-channel activity, (b) a shift of the zero-current membrane potential close to 0 mV, and (c) a suppression of a depolarizatlon-activated K* conductance. All of these changes in tumor cell excitability act coordinately to depolarize the tumor cells and may be important in the cytostatic actions of LR

PAMELA Overview : design goals and principles

The PAMELA (Particle Accelerator for MEdicaL Applications) project is to design an accelerator for proton and light ion therapy using non-scaling Fixed Field Alternating Gradient (FFAG) accelerators, as part of the CONFORM project, which is also constructing the EMMA electron model of a non-scaling FFAG at Daresbury. This paper presents an overview of the PAMELA design, and a discussion of the design goals and the principles used to arrive at a preliminary specification of the accelerator

PAMELA overiew and status

The status of PAMELA (Particle Accelerator for MEdical Applications) – an accelerator for proton and light ion therapy using a non-scaling FFAG (ns-FFAG) accelerator – is reviewed and discussed

PAMELA : overview and status

The status of the PAMELA (Particle Accelerator for MEdical Applications) project to design an accelerator for proton and light ion therapy using non-scaling Fixed Field Alternating Gradient (ns-FFAG) accelerators is reviewed and discussed

Biological and molecular characteristics of leukoregulin action

No abstract available