Effects of Low Caloric Diet with and without Vitamin D Supplementation on Anthropometric Parameters in Patients with Non-alcoholic Fatty Liver

Introduction: There are evidences that show the effect of vitamin D on obesity. The relationship between vitamin D deficiency and nonalcoholic fatty liver (NAFLD) is under review. The purpose of this study was to investigate the effect of vitamin D supplementation along with a low caloric diet on liver enzymes and anthropometric parameters in NAFLD patients. Methods: This study is a randomized clinical trial involved 80 NAFLD patients with vitamin D deficiency. Both groups used vitamin D or placebo for 12 weeks, one time a week. Liver enzymes, ultrasound of the liver and bile ducts and anthropometric parameters were measured before and after intervention. Results: The study was completed by 73 subjects. After 12 weeks, liver enzymes and the degree of fatty liver in the intervention group compared with the placebo group were significantly decreased (P<0.005). About 9 kg of body weight in the intervention group compared to the beginning of the intervention decreased (P<0.005). Conclusion: Vitamin D supplementation along with a low calorie diet in NAFLD patients with hypovitaminosis D significantly effect on anthropometric factors decrease and liver enzymes and the degree fatty liver improvement