POWDER SOLUTION TECHNOLOGY REVIEW

Bioavailability and Solubility are the challenges for the formulation of highly lipophilic drugs. Oral routes of administration is one of the acceptable route due to improved patient compliance and convenience. Regularly newly advanced drug candidates are lipophilic, BCS Class II and IV drugs. Among various methods to improve the solubility of these drugs, liquid-solid technology or Powdered solution technology change the liquid drug into non-sticky, dry free-flowing, rapid release powder. This technique involves mixing of insoluble drug with nonvolatile solvent, admixing of drug-loaded excipients change into loose powder. This technique enhances major challenges like bioavailability with low production cost and a simple manufacturing process

A review on recent advancement in liquisolid techology

Liquisolid technique is a novel process in which a liquid can be converted into a material that flows freely, is readily compressible. The carrier material in liquisolid compact comprises the liquid part, which is the liquid drug or a drug solution in liquid vehicles that are non-volatile. Solubility is the main parameter in the circulation of blood to achieve the whole concentration of the drug for pharmacological action. The rate of dissolution of drugs enhances in liquisolid technology. This in turn increases absorption and bioavailability subsequently. This review discusses the different advances and changes to improve liquisolid technology formulations and enhancement of dissolution rate of poorly soluble drugs. Most of the new chemical entities have high lipophilicity and poor water solubility, resulting in poor bioavailability. The release rate of these drugs should be increased in order to improve bioavailability. The technique is based on dissolving the insoluble drug in the solution loaded with non-volatile solvent. Then the dissolution rate of drug which is poorly soluble will rise. The enhanced bioavailability is due to the increased surface area of drug for release, increased drug aqueous solubility or improved wetting capacity

MICROFLUIDIC DEVICES AS A TOOL FOR DRUG DELIVERY AND DIAGNOSIS: A REVIEW

Microfluidic devices are a good example of the collaboration of chemical, biological, and engineering sciences. Microfluidic devices emerge as an in fluent technology which provides an alternative to conventional laboratory methods. These devices are employed for the precise handling and transport precise quantities of drugs without toxicity. This system is emerging as a promising platform for designing advanced drug delivery systems and analysis of biological phenomena on miniature devices for easy diagnosis. Microfluidics enables the fabrication of drug carriers with controlled geometry and specific target sites. Microfluidic devices are also used for the diagnosis of cancer circulating tumor cells. In the current review, different microfluidic drug delivery systems and diagnostic devices have described

Short review on domperidone tablet

Oral route is presently the gold standard in the pharmaceutical industry where it is regarded as the safest, most economical and most convenient method of drug delivery resulting in highest patient compliance. Pediatric and geriatric patients find it difficult to swallow solid dosage forms like tablets. Mouth dissolving tablet that dissolve or disintegrate rapidly in oral cavity result in solution, is an ultimate remedy for this problem in addition they give pleasing mouth feeling. ODT has advantages such as patient compliance, quick onset of action, improved bioavailability. Domperidone tablet (ODT) gives relief from nausea, vomiting. This review gives us all information about pharmacokinetic, pharmacodynamic, uses, precautions, side effects of domperidone tablet

Smartphone use and its addiction among Jammu adolescents

Background: Smartphones play a crucial role in our everyday life. Smartphones help users to develop social connections with others, gain information and entertain themselves through various applications. With the widespread use of smartphone, the number of smartphone users has been increasing worldwide. As smartphones are getting popular, smartphone addiction has become a serious mental health problem among adolescents. Objectives: To find out significant differences in smartphone addiction among adolescents with respect to their gender and locale. Methodology: Descriptive survey method was used for conducting the study. The sample consists of 200 adolescents of government and private schools from Jammu and Kathua. ‘Smartphone Addiction Scale’ (2021) developed by Vijayshri and Masaud Ansari was used for data collection. Results: It was found that smartphone addiction was significantly higher among female adolescents (M=65.34) as compared to their male counterparts (58.61). Further, it was also found that smartphone addiction was significantly higher in urban adolescents (M=64.37) than rural adolescents (M=59.08). Conclusion: In order to combat smartphone addiction among adolescents, we advise the creation of healthy environment at the family and school levels. Teachers should provide knowledge to the students about smartphone security tips and educational programmes should be organized for protecting psychological well-being of the adolescents

An Automatic Segmentation & Detection of Blood Vessels and Optic Disc in Retinal Images

Conceptual Segmentation is a critical technique in medical imaging. The Processes of identification and division of optic circle and veins are the fundamental strides for the analysis of a few infections that causes visual deficiency like diabetic retinopathy, hypertension, glaucoma and different visual deficiency ailment

VARIATIONS IN MORPHOLOGY OF LEPTOCENTRUS BAJULANS (MEMBRACIDAE : HOMOPTERA) FEEDING ON EIGHT HOST PLANTS

Leptocentrus bajulans is a polyphagous membracid species show morphometric variations on eight different host plants i.e Cassia glauca (Lam); Cestrum diurnum (Linn.); Lawsonia alba (Lamk.); Tamarandus indica (Linn); Emblica qfficinalis (Gaertn.); Dalbergia sissoo (Roxb.); Cassia fistula (Linn), Albizzia lebbeck (Benth.); has been observed and incorporated in this paper. These observations were also compared with environmental factors. Observations revealed that female insects in general larger than male irrespective of host plant on which it is feeding. As far as the host value is concerned Cassia fistula is the best host as nearly all the morphometric characteristics show an upward value in the insects feeding on it. Another conclusion is that different host plants result in differential development of various parameter in the individuals of the same species

Comparative Study of Ni and Cu Doped Zno Nanoparticles: Structural and Optical Properties

Nanoparticles of undoped and doped (0.1 M Ni2+ and Cu2+) ZnO are synthesized using chemical precipitation method. The crystallite size, morphology, chemical bonding and optical properties of as prepared nanoparticles are determined by X-ray diffraction (XRD), Scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy and UV-visible spectra. XRD analysis shows that the prepared samples are single phase and have hexagonal wurtzite structure. The crystallite size of the doped and undoped nanoparticles is determined using Scherrer method. The crystallite size is found to be increased with concentration of nickel and copper. All stretching and vibrational bands are observed at their specific positions through FTIR. The increase in band gap can be attributed to the different chemical nature of dopant and host cation

Review of WiMax Services & Security Threats

Abstract-No