Chronic ectopic pregnancy complicated by septicemic shock and disseminated intravascular coagulation

Disseminated intravascular coagulation is a life threatening complication of ectopic pregnancy. It results from washing out of all important procoagulants. This is basically a state of increased propensity for clot formation triggered by a variety of stimuli related to such diverse disorders as sepsis ,endothelial cell damage (heat stroke and shock), obstetrical complication (abruptio placenta, amniotic fluid embolism, severe preeclampsia and retained intrauterine dead foetus). A case of disseminated intravascular coagulation with septicemic shock following laprotomy for ectopic pregnancy is reported. She was treated by vasopressors, broad spectrum antibiotic and aggressive blood and blood component therapy

Effect of Sand Training on Jumping Abilities of Junior Volleyball Players

The purpose of the study was  to determine the effect of sand training on jumping abilities of junior volleyball players. For this purpose, thirty  junior volleyball players enrolled in  the S.A. I. training centre  for volleyball at  Rajnandgaon (CG) under the day boarding scheme, age ranging from 16 to 19 years, were selected as the subjects of the study. Subjects were divided randomly in two equal groups Group-A (n=15) and Group-B (n=15). Group-A  went for a program selected for  sand training for a period of 6 weeks and  group 'B' was the  control group.  The subjects of the  control group and experimental group had trained volleyball prior to the experimental program for a period of two and  four years respectively. Measurement for various variables taken at the beginning  (Pre-test)and at the end of experimental period after 6 weeks Post-test). The Mean, S.D. and t-test  were computed by the investigator for the collected  data. The difference of pre-test and post-test scores were  taken into account. The level of significance was   set at .05 level of confidence. The analysis of data revealed that the six-week sand training program  has an effect on the statistically relevant increase in the explosive type strength of the leg muscles, which in turn leads to an increase in the vertical jump of a block, spike and the long jump. The technical and tactical training program to a lesser extent in comparison to the experimental group has an effect on the development of explosive type strength. Keywords: Sand training, Explosive strength, Jumping ability, Junior Volleyball player

A Comparative Study of Personality Traits of Coaches and Physical Education Teachers

The purpose of the  study was to  investigate and compare the personality traits of coaches and physical education teachers.  One hundred coaches of individual and team games (N=50) and physical education teachers (N=50)  were  selected  for the purpose of study. To compare the personality traits of coaches and physical education teachers, 16 P.F., questionnaire developed by  Cattell, R.B. Eber, H.W. and Tatsuoka, M.M. (1970) was selected as criterion measure. The questionnaire in both Hindi and English version were  used.  To collect the reliable data,  the subjects were contacted at the place of posting and time was fixed to give the answer of the questions (30 to 60 Minutes). To assess the personality traits of sports coaches  and physical education teachers,  mean of sten scores and standard deviation for each of the 16 P.F. were computed.  To determine the significance of difference between coaches  and physical education teachers in their mean sten scores of the different personality factors, t-test was computed. Results of the study indicated  that coaches  and physical education teachers were largely found to be moderately, reserved, intelligent, trustable, practical, straight forward, placid, dependent, confused, relaxed and had  different personality traits. Keywords: Coach, Physical Education Teacher, Personality Traits, 16 P.F

Effect of Storage Temperature on Bio efficacy of Aqueous Extract of Ganoderma lucidum

Stability testing is key requirement in the drug development process along with storage temperature which may deteriorate bio-constituents and efficacy of natural products. Aqueous extract of Ganoderma lucidum has revealed pharmacological effects against high altitude stressors and has potential for mitigating high altitude maladies. In the present study, the extract of Ganoderma lucidum was stored at different storage conditions such as room temperature, 4 °C and -20 °C for two year and qualitative and quantitative analysis of bio-constituents and bio-efficacy was carried out. No significant change was observed in any extract kept in different temperature conditions in terms of its polysaccharide, phenolic and flavonoids content. The extract kept at room temperature absorbed slight moisture in few samples but no change in overall polysaccharide, phenolic and flavonoids content was recorded. The moisture absorption problem was not observed in extracts stored at 4 °C and -20 °C. The bio-efficacy of the extract at room temperature, 4 °C or -20 °C were comparable to the freshly prepared extract and the data from the studies suggest that extract has good shelf life up to two year without loss of bio-efficacy. Overall, the extract retained its bio-efficacy for two years at different temperature storage conditions

Comparision of efficacy of visual inspection of cervix with acetic acid, Pap smear and colposcopy for prevention of cervical cancer

Background: Cervical cancer is second most common cancer in women globally. Overall 80% cases occurs in developing countries.  An important reason for the high incidence of cervical cancer in developing countries is the lack of effective screening programs to detect precancerous conditions and treat before it progresses to invasive cancer due to severe restrictions on the availability of infrastructure, resources and funding. Aim of this study was to compare the sensitivity, specificity, PPV, and NPV of VIA, Pap smear and colposcopy with colposcopic directed biopsy (as a gold standard). Methods: This prospective analytical study was conducted on 200 women’s (age>19 years) with abnormal cervix in the Department Of Obstetrics and Gynaecology, Government Medical College Kota from 1 august 2020 to 31 July 2022 who fulfil the Inclusion criteria. All the Symptomatic patients with symptoms like vaginal discharge postcoital bleeding, itching, and other gynaecological problems along with asymptomatic patients with accidental finding of bad cervix (cervical erosion). Results: Maximum cases had common complaint of discharge per vaginum (60.55%), followed by post coital bleeding (11.5%). VIA when compared with HPR, had sensitivity 94.85% and specificity 74.76% and corresponding PPV 78% and NPV 94%. Paps smear when compared with HPR, the sensitivity was 62.89% and specificity was 89.32% and corresponding PPV 84.72% and NPV 71.88%. Colposcopy when compared with Histopathological report, the sensitivity was 70% and specificity was 91.26% and corresponding PPV 88.3% and NPV 76.4%. Conclusions: Best result for early detection of pre-invasive lesions could be with combined use of Pap smear, VIA, colposcopy and colposcopy guided biopsy rather than any individual diagnostic procedure. It will immensely reduce the morbidity and mortality

REVIEW ON PHORBOL ESTER DEGRADATION OF JATROPHA SEED CAKE FOR ITS USE AS ANIMAL FEED

Jatropha curcas is an oil-seed plant with good adaptability to grow in unfavourable conditions like infertile soil with scanty rainfall. It had been exploited for the extraction of oil for bio-diesel. The compressed seed cake, after the oil extraction, is a rich source of protein with certain toxic and anti-nutritional factors. The major toxins in the seed cake are phorbol esters and trypsin inhibitors that lead to various health problems if ingested. Even though the application of the various extracts carries a lot of beneficial advantages, yet the toxicity in oil and the compressed cake does not allow the by-products and the oil to be used elsewhere. Various physicochemical and biological methods have been described for the detoxification of Jatropha seed cake and oil of which the chemical extraction with methanol and ethanol have shown promising results in reducing the toxin contents by 97-100% while UV-irradiation reduced the phorbol esters completely. Submerged fermentation by Bacillus sp. achieved complete detoxification of phorbol esters within a week. A new strain was found to degrade the phorbol esters to phorbol, myristic acid and acetic acid within 12 h of incubation in submerged fermentation process. The detoxified products, in future, can be used as animal feed and food supplement to help utilize the by-products as a healthy diet

Metabolic fingerprinting of joint tissue of collagen-induced arthritis (CIA) rat

Rheumatoid arthritis (RA) is a systemic autoimmune disease whose major characteristics persistent joint inflammation that results in joint destruction and failure of the function. Collagen-induced arthritis (CIA) rat is an autoimmune disease model and in many ways shares features with RA. The CIA is associated with systemic manifestations, including alterations in the metabolism. Nuclear magnetic resonance (NMR) spectroscopy-based metabolomics has been successfully applied to the perchloric acid extract of the joint tissue of CIA rat and control rat for the analysis of aqueous metabolites. GPC (Glycerophosphocholine), carnitine, acetate, and creatinine were important discriminators of CIA rats as compared to control rats. Level of lactate (significance; p = 0.004), alanine (p = 0.025), BCA (Branched-chain amino acids) (p = 0.006) and creatinine (p = 0.023) was significantly higher in CIA rats as compared to control rats. Choline (p = 0.038) and GPC (p = 0.009) were significantly reduced in CIA rats as compared to control rats. Choline to GPC correlation was good and negative (Pearson correlation = -0.63) for CIA rats as well as for control rats (Pearson correlation = -0.79). All these analyses collectively considered as metabolic fingerprinting of the joint tissue of CIA rat as compared to control rat. The metabolic fingerprinting of joint tissue of CIA rats was different as compared to control rats. The metabolic fingerprinting reflects inflammatory disease activity in CIA rats with synovitis, demonstrating that underlying inflammatory process drives significant changes in metabolism that can be measured in the joint tissue. Therefore, the outcome of this study may be helpful for understanding the mechanism of metabolic processes in RA. This may be also helpful for the development of advanced diagnostic methods and therapy for RA

On Intuitionistic Fuzzy Entropy of Order-α

Using the idea of Rènyi’s entropy, intuitionistic fuzzy entropy of order-α is proposed in the setting of intuitionistic fuzzy sets theory. This measure is a generalized version of fuzzy entropy of order-α proposed by Bhandari and Pal and intuitionistic fuzzy entropy defined by Vlachos and Sergiadis. Our study of the four essential and some other properties of the proposed measure clearly establishes the validity of the measure as intuitionistic fuzzy entropy. Finally, a numerical example is given to show that the proposed entropy measure for intuitionistic fuzzy set is reasonable by comparing it with other existing entropies

SLA Management in Intent-Driven Service Management Systems: A Taxonomy and Future Directions

Traditionally, network and system administrators are responsible for designing, configuring, and resolving the Internet service requests. Human-driven system configuration and management are proving unsatisfactory due to the recent interest in time-sensitive applications with stringent quality of service (QoS). Aiming to transition from the traditional human-driven to zero-touch service management in the field of networks and computing, intent-driven service management (IDSM) has been proposed as a response to stringent quality of service requirements. In IDSM, users express their service requirements in a declarative manner as intents. IDSM, with the help of closed control-loop operations, perform configurations and deployments, autonomously to meet service request requirements. The result is a faster deployment of Internet services and reduction in configuration errors caused by manual operations, which in turn reduces the service-level agreement (SLA) violations. In the early stages of development, IDSM systems require attention from industry as well as academia. In an attempt to fill the gaps in current research, we conducted a systematic literature review of SLA management in IDSM systems. As an outcome, we have identified four IDSM intent management activities and proposed a taxonomy for each activity. Analysis of all studies and future research directions, are presented in the conclusions.Comment: Extended version of the preprint submitted at ACM Computing Surveys (CSUR

TO EVALUATE THE EFFECT OF INTRAVITREAL INJECTION OF TRIAMCINOLONE ACETONIDE IN RECALCITRANT MACULAR DISORDERS.

Objectives: Recalcitrant macular disorders are those retinal conditions which, though treated by various medical and surgical modalities, but showedno improvement in symptoms or visual acuity or both. The present study was carried out to evaluate the efficacy of intravitreal triamcinoloneacetonide (TA) injection in patients with these recalcitrant macular disorders.Methods: This prospective and interventional study included 40 patients (40 eyes) having recalcitrant macular disorders. Complete ophthalmicexamination such as measurement of intraocular pressure (IOP), visual acuity (log minimal angle of resolution [MAR] units), fundus photography withfluorescein angiography were carried out before and after intravitreal injection of TA. The patients received an intravitreal injection of TA (10 mg) fordiabetic macular edema (n=14), age-related macular degeneration (n=13), pars plana cystoid macular edema (CME) (n=5), vascular diseases (n=3),central chorioretinopathy (n=3), and idiopathic CME (n=2). The follow-up was done on day 1, day 7, 1 month, 2 month and 4-month intervals.Results: The mean visual acuity at 2 months (1.12±0.45 log MAR units), and 4 months (1.08±0.46 log MAR unit) after the injection were significantlybetter than baseline measurements (1.32±0.3 log MAR units). The mean baseline IOP was 12.5±2.9 mmHg. The IOP significantly increased after theinjection at day 1 and day 7; however, the change in IOP at 1 month, 2 months, and 4 months was not statistically significant.Conclusion: The results indicate that intravitreal injection of TA in patients with recalcitrant macular disorders caused significant improvement ofvisual acuity in 10 mg dose.Keywords: Intravitreal triamcinolone acetonide, Macular edema, Visual acuity, Intraocular pressure