Global toxicology research output (2008-2017): A scientometric analysis

In this study a scientometric analysis of the global toxicology research output during 2008-2017 was performed based on the data retrieved from SCOPUS database. This study analyses the global research output in toxicology research on different parameters including the growth, global publication share and rank, contribution of major subject areas, contribution and citation impact of the most productive authors, affiliations and journals. A total of 29374 papers were published during 2008-2017 on toxicology research. Top 10 countries contributed 85.68% share of total publications. The United States ranks first in terms of number of publications with a global publication share of 35.84% and h-index of 166. Almost 46.03% publications are in the field of Pharmacology, Toxicology and Pharmaceutics. United States Environmental Protection Agency received the highest h-index (75) among the top 15 affiliations. Toxicological Sciences was the top journal in terms of publication output (2272 publications) and registered the highest h-index of 102 with an average citation per publication of 29.51

To determine the role of targeted four node sampling (FNS) in axillary mapping in operable breast cancer

Aim: to determine the role of targeted four node sampling (FNS) in axillary mapping in operable breast cancer. Methods: The present analytical hospital based study was conducted among histopathologically and cytologically confirmed patients of operable breast cancer admitted to inpatient department of General Surgery, Sri Krishna Medical College and Hospital, Muzaffarpur, India July 2019 to February 2020. A total of 30 patients, node negative operable cases of carcinoma breast after 3 cycles of neoadjuvant chemotherapy, were enrolled. Lymph node mapping was done by injecting 3 - 5 ml of methylene blue dye, just before surgery. Results: The sensitivity, specificity, positive predictive value and negative predictive value of 83.12%, 90.27%, 72.31% and 94.25% respectively for four node sampling of axilla, among operable breast cancer patients having node negative axilla. Conclusions: Targeted four node sampling using methylene blue dye can be considered as an alternative method for sentinel lymph node. Further study should be conducted to establish it as a reliable method for axillary lymph node staging

Design and Simulation of Multi Objective Power Flow Optimization in IEEE-30 Bus System using Modified Particle Swarm Optimization

Execution and Reliability of OPF algorithms is an important issue of research for gainful power structure control and orchestrating. Perfect Power Flow is driven for restricting the objective work. This objective limit can be single regarded target work or different objective limits. In the present research, we have executed perfect power stream in order to constrain the fuel cost while satisfying the constraints, for instance, the voltages, power yields of the generator kept inside embraced purpose of repression. Some other objective can be used reliant on utility's preferred position and needs. Many streamlined framework models have been combined in the past by various researchers for OPF issue, for instance, Linear Programming, Non Linear Programming, Quadratic Programming, Newton Based Techniques, Parametric Methods, and Interior Point Methods, etc. A wide variety of bleeding edge optimization methodologies like Evolutionary Programming, Genetic Algorithm, PSO Algorithm, etc are proposed recorded as a hard copy for handling OPF issue. In this proposition, we have executed improved particle swarm optimization algorithm to restrain cost limit while keeping goals inside acceptable most extreme. The adjustments in particle swarm optimization is finished by introducing the idea of quantum computing and optimization of quickening coefficients. The proposed algorithm is associated with IEEE-30 bus structure. Resuts indicated unrivaled execution of proposed algorithm as contrasted and contemporary techniques

To obtain information about prescribing pattern of antibiotics: a prospective hospital based observational study

Objective: To obtain information about prescribing pattern of antibiotics in the tertiary care teaching hospital. Methods: The present prospective hospital based observational study was conducted among patients admitted to inpatient department of General Surgery, Sri Krishna Medical College and Hospital, Muzaffarpur, India from April 2019 to October 2019. Patients above 18 years of either sex were included in the study. Results: A total of 138 prescriptions were studied. Mean age of the study population was 38.16 years. Mean number of medicines prescribed per prescription was 4.69 and mean number of antibiotics per prescription was 2.18. Conclusion: Cephalosporin was the preferred or most prescribed choice of drug for prophylaxis followed by penicillin’s. Our study brings to the fore some common but serious lapses in antibiotic prescription patterns and emphasizes the need for proper and appropriate use of antibiotics

Evaluation of the pancreatic malignancy with MRI & MDCT modalities

Background:Detection of pancreatic abnormality by routine noninvasive radiological method namely plain radiography and gastrointestinal barium studies is possible but these tests are insensitive and nonspecific. In earlier era more invasive tests like retroperitoneal air insufflations with tomography used never achieved wide spread clinical application and isotope scan proved disappointing owing to their false positive rates. Material & Methods:The present retrospective study was conducted at department of Department of Radiology at MRI Centre, M.B. Govt. Hospital, Udaipur. The study duration was December 2012 to November 2014. The study group of 100 patients, with suspected pancreatic diseases were examined using either MDCT scan or MRI or both as prime diagnostic modality.Results: In the present study, Pancreatic carcinoma is a hypo vascular mass so it does not enhance at all or show a mild enhancement on post contrast study. In this study out of 14 cases, 14 cases showed mild post contrast enhancement and 2 cases showed no enhancement at all. on CECT examination, out of 10 cases of head mass, 8 cases were hypo dense and 2 were Isodense and showed dilated MPD in 9 cases 90.00% which were most common finding followed by dilated CBD in 8 cases (80.00%) and invasion of other organs in 2 cases (20%). On MRI examination, out of 4 cases of head carcinoma, 3 appeared hyperintense & 1 appeared hypointense and showed dilatation of MPD & CBD in all cases and invasion of organ in one case. Out of 14 cases of head carcinoma, 4 (28.57%) cases showed distal metastasis in liver. Out of 7 cases of body-tail mass, six appeared hypo dense and one appeared on NCCT. Distant metastasis and dilated MPD were found in 4 cases and CBD were dilated in any one case of body mass. Conclusion: We concluded from the present study that Dual-phasic contrast-enhanced MDCT in the pancreatic parenchymal and the venous phase is the method of choice for detection and staging of pancreatic cancer, inflammatory lesions and its vascular complications. For detection of small, hyper vascular neuroendocrine tumors, no single imaging method will reveal all tumors. In this respect, MDCT and MRI are complementary methods

Sustenance in Chronic Kidney Disease: Beyond the Calorie Count

Diet and nutrition play key roles in the management of metabolic disorders like hypertension, obesity, hyperlipidemia and diabetes. All these conditions are linked with the pathogenesis of chronic kidney disease (CKD). Patients with CKD frequently exhibit a progressive loss of muscle and fat mass that may not be related to reduced intake alone. This article provides a comprehensive overview of protein-energy wasting (PEW) in CKD, including its etiology and the obesity paradox and the nutritional guiding principles

A CORRELATION STUDY BETWEEN TRANSCUTANEOUS BILIRUBIN AND TOTAL SERUM BILIRUBIN LEVELS AMONG NEONATES

Objective: The availability of modern bilirubin meters that measure bilirubin concentration in dermal and subcutaneous tissues has made it possible to obtain serial, non-invasive (i.e., painless) TcB (transcutaneous bilirubin) measurements. However, concerns have been raised regarding the appropriateness of comparing these TcB values to serum bilirubin values. This study aims to find a correlation between transcutaneous bilirubin and total serum bilirubin. Methods: Prospective analytic study carried out in NICU of Govt. RDBP Jaipuria Hospital. Newborn babies up to the 10th postnatal day of life with visually found jaundice had been enrolled in the study. TcB was measured over mid-sternum with Dräger JM 105™ device. Simultaneous total serum bilirubin (TSB) measurements had been done. Pearson’s correlation coefficient and Bland–Altman analysis had been done. ROC curves of mean TcB at different TSB level had been constructed. Results: In the study, 120 babies had been included. A significant correlation was founded between TcB and TSB measured values. Pearson’s correlation coefficient was 0.892 (p<0.001). The average error in evaluating hyperbilirubinemia with TcB compared to TSB was 0.101, with limits of agreement between −3.73 and +3.55. The AUOC at three TSB levels (>10 mg/dl, >12 mg/dl, and >15 mg/dl) was 0.860, 0.892, and 0.849. Conclusion: In our study, TcB measurements correlated well with TSB measurements and validated its use as a screening tool for the evaluation of jaundice in newborns