Ulcerated nasal infantile haemangioma treated by oral propranolol

Infantile hemangioma affects about 10% of neonates, but usually involutes without significant complications. Complications may include disfigurement, bleeding, and ulceration, along with airway, cardiac, hepatic, and spinal complications depending upon site. Oral propranolol is now the treatment of choice in many situations. Herein we present an infant with a large hemangioma on the nose tip and show the dramatic results with the use of propranolol. The patient received seven months of therapy at 2 mg/kg/day propranolol orally in three divided doses. The response started within a few weeks and by the eighth week ulceration had healed completely without scarring

Diphenylcyclopropenone-Induced Vitiligo in a Patient with Alopecia Universalis

Alopecia areata and vitiligo are autoimmune diseases, both associated with multiple autoimmune comorbidities. Many studies show colocalization of these diseases at the same anatomical site. Here, we have a case where both disorders were reported to present in the same patient. Diphenylcyclopropenone (diphencyprone, DCP) is used in the treatment of alopecia areata and may induce vitiligo in some patients. We report on one case of vitiligo that was induced by DCP during therapy for alopecia universalis. Alopecia areata and vitiligo share many susceptibility genes. Follicular melanocyte destruction may represent the link between the two diseases

Pruritic Vesicular Eruption on the Lower Legs in a Diabetic Female

A 50-year-old diabetic female presented with highly pruritic vesicles and excoriated lesions over the anterior aspect of both lower legs. The lesions were recurrent over the last two years. She received a lot of medications with partial response. Hb A1c was 10.8% (normal up to 7%). CBC showed microcytic, hypochromic anemia. Serum zinc, folate, IgE, TSH and T4 were all within normal ranges. Biopsy showed epidermal separation secondary to keratinocyte necrosis and minimal monocytic, perivascular infiltrate. Direct immunofluorescence was negative for intraepidermal and subepidremal deposition of immunoglobulin. The dermis was positive for mucin deposition stainable by both PAS and Alcian blue while it was negative for Congo red and APC immunoperoxidase staining for amyloid material. In conclusion, the case was diagnosed as bullosis diabeticorum by distinctive clinical and pathological features and after exclusion of other possible differentials. Pruritus was partially controlled by topical potent steroid and the case was resolved spontaneously after eight months