Methyl (E)-3-(2-bromo-4,5-dimeth­oxy­benzyl­idene)dithio­carbazate

The title compound, C11H13BrN2O2S2, was obtained from the condensation reaction of methyl dithio­carbazate and 2-bromo-4,5-dimeth­oxy­benzaldehyde. In the mol­ecule, the benzene ring and dithio­carbazate fragment are located on opposite sides of the C=N bond, showing an E conformation. The dithio­carbazate fragment is approximately planar (r.m.s deviation = 0.0281 Å) and the mean plane is oriented at a dihedral angle of 11.38 (15)° with respect to the benzene ring. In the crystal, pairs of N—H⋯S hydrogen bonds link the mol­ecules into centrosymmetric dimers

Benzyl (E)-3-(2-methyl­benzyl­idene)dithio­carbazate

The title compound, C16H16N2S2, was obtained from the condensation reaction of benzyl dithio­carbazate and 2-methyl­benzaldehyde. The asymmetric unit contains two independent mol­ecules. In both mol­ecules, the methyl­phenyl ring and the dithio­carbazate fragment are located on opposite sides of the C=N bond, showing an E conformation. In each mol­ecule, the dithio­carbazate fragment is approximately planar, the r.m.s deviations being 0.018 and 0.025 Å. The mean plane of dithio­carbazate group is oriented at dihedral angles of 7.9 (3) and 68.24 (12)°, respectively, to the methyl­phenyl and phenyl rings in one mol­ecule, while the corresponding angles in the other mol­ecule are 10.9 (3) and 69.76 (16)°. Inter­molecular N—H⋯S hydrogen bonding occurs in the crystal structure to generate inversion dimers for both molecules

Multi-Scale Expressions of One Optimal State Regulated by Dopamine in the Prefrontal Cortex

The prefrontal cortex (PFC), which plays key roles in many higher cognitive processes, is a hierarchical system consisting of multi-scale organizations. Optimizing the working state at each scale is essential for PFC's information processing. Typical optimal working states at different scales have been separately reported, including the dopamine-mediated inverted-U profile of the working memory (WM) at the system level, critical dynamics at the network level, and detailed balance of excitatory and inhibitory currents (E/I balance) at the cellular level. However, it remains unclear whether these states are scale-specific expressions of the same optimal state and, if so, what is the underlying mechanism for its regulation traversing across scales. Here, by studying a neural network model, we show that the optimal performance of WM co-occurs with the critical dynamics at the network level and the E/I balance at the level of individual neurons, suggesting the existence of a unified, multi-scale optimal state for the PFC. Importantly, such a state could be modulated by dopamine at the synaptic level through a series of U or inverted-U profiles. These results suggest that seemingly different optimal states for specific scales are multi-scale expressions of one condition regulated by dopamine. Our work suggests a cross-scale perspective to understand the PFC function and its modulation

3-Chloro-6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinic acid–triphenyl­phosphine oxide (1/1)

In the title 1:1 adduct, C11H10ClN3O2·C18H15OP, the dihedral angle between the pyridine and pyrazole rings is 10.3 (2)°. The two components of the adduct are linked by an O—H⋯O hydrogen bond

Benzyl (E)-3-(4-meth­oxy­benzyl­idene)dithio­carbazate

The title compound, C16H16N2OS2, was obtained from a condensation reaction of benzyl dithio­carbazate and 4-meth­oxy­benzaldehyde. In the mol­ecule, the meth­oxy­phenyl ring and dithio­carbazate fragment are located on opposite sides of the C=N double bond, showing an E configuration. The dithio­carbazate fragment is approximately planar (r.m.s. deviation = 0.0052 Å); its mean plane is oriented at dihedral angles of 8.19 (15) and 85.70 (13)°, respectively, to the meth­oxy­phenyl and phenyl rings. Inter­molecular N—H⋯S hydrogen bonds and weak C—H⋯π inter­actions are observed in the crystal structure

Entanglement and quantum phase transition in alternating XY spin chain with next-nearest neighbour interactions

By using the method of density-matrix renormalization-group to solve the different spin-spin correlation functions, the nearest-neighbouring entanglement(NNE) and next-nearest-neighbouring entanglement(NNNE) of one-dimensional alternating Heisenberg XY spin chain is investigated in the presence of alternating nearest neighbour interactions of exchange couplings, external magnetic fields and next-nearest neighbouring interactions. For dimerized ferromagnetic spin chain, NNNE appears only above the critical dimerized interaction, meanwhile, the dimerized interaction effects quantum phase transition point and improves NNNE to a large value. We also study the effect of ferromagnetic or antiferromagnetic next-nearest neighboring (NNN) interactions on the dynamics of NNE and NNNE. The ferromagnetic NNN interaction increases and shrinks NNE below and above critical frustrated interaction respectively, while the antiferromagnetic NNN interaction always decreases NNE. The antiferromagnetic NNN interaction results to a larger value of NNNE in comparison to the case when the NNN interaction is ferromagnetic.Comment: 13 pages, 4 figures,. accepted by Chinese Physics B 2008 11 (in press