The Sustainability Strategy Analysis of EON UK

The energy sector plays a key role in sustainable development. Not only does it drives economic and social progress but also impacts on the environment. EON UK is one of the major energy suppliers in the UK power industry, it is critical to establish a sustainable strategy for the organisational development in the long-run. The purpose of this paper is to analyse the sustainability strategy of EON UK. The key questions include: Is the company's current stand sustainable? How does EON achieve long-term sustainability in practice? This paper endeavours to answer these questions by conducting a literature review; abiding to a rigid methodology; analysing the corporate strategy and realities via three standpoints as economical, environmental and social sustainability; cross checking the issues and identifying the gap of EON UK's sustainable strategy. The research question will be answered, and recommendations will be provided to point the direction for the sustainability development of EON UK

EON UK CORPORATE SCENARIO PLANNING 2020

Abstract This research project sets out to explore how scenarios can help to develop strategy in conditions of uncertainty. It suggests that scenarios can be used as intermediary objects to discuss alternative scenarios and generate new strategic approaches. The paper sets to explore how scenario planning is linked to strategy examining a practical application of scenario planning at EON, worlds largest privately owned energy provider. The purpose of this intervention in EON was to examine the scenarios provided by EON and test the assumptions on which the scenarios were based. Furthermore, new set of scenarios were created from a new set of drivers of the energy industry. The paper also lays out the key drivers of the energy industry in UK and its possible impacts on EON. The research method included studying governmental and its regulators white papers and reports based on energy market and the industry. Other perspectives of consumers, environmentalists, competition, technology, developing economies were also taken into consideration. The scenarios were created from the PEST analysis and from the observation of the participants, some of which from were from EON. From a theoretical point of view, an important finding of the paper is the emphasis upon the need to analyse the gaps between EON UK strategy and its reference case- Climate concern. The paper suggests that gap analysis can be powerful tool for both scenario planning and further action planning. The identification of gaps can challenge our thought process and create scope for learning. It is also suggested that a wild card scenario approach puts weak signals or survival issues on the radar of the strategy department. The outcome of the research demonstrates that the process of scenario planning, analysis and gap identification have the potential to provide an organization for skillful and meaningful strategic conversation. A strategic conversation based on analysis creates a whole new picture filled new ideas for the management and its organization. In EON case too, the paper sets out to illustrate the new possibilities and what might be. Although in a world of immense uncertainties it would be challenging for the organization to embark on its new journey based on the recommendation

Traditional Chinese Medicine Diagnosis “ Yang-Xu Zheng

Pathogenesis of sepsis includes complex interaction between pathogen activities and host response, manifesting highly variable signs and symptoms, possibly delaying diagnosis and timely life-saving interventions. This study applies traditional Chinese medicine (TCM) Zheng diagnosis in patients with severe sepsis and septic shock to evaluate its adaptability and use as an early predictor of sepsis mortality. Three-year prospective observational study enrolled 126 septic patients. TCM Zheng diagnosis, Acute Physiology and Chronic Health Evaluation (APACHE) II score, and blood samples for host response cytokines measurement (tumor necrosis factor-α, Interleukin-6, Interleukin-8, Interleukin-10, Interleukin-18) were collected within 24 hours after admission to Intensive Care Unit. Main outcome was 28-day mortality; multivariate logistic regression analysis served to determine predictive variables of the sepsis mortality. APACHE II score, frequency of Nutrient-phase heat, and Qi-Xu and Yang-Xu Zhengs were significantly higher in nonsurvivors. The multivariate logistic regression analysis identified Yang-Xu Zheng as the outcome predictor. APACHE II score and levels of five host response cytokines between patients with and without Yang-Xu Zheng revealed significant differences. Furthermore, cool extremities and weak pulse, both diagnostic signs of Yang-Xu Zheng, were also proven independent predictors of sepsis mortality. TCM diagnosis “Yang-Xu Zheng” may provide a new mortality predictor for septic patients

Investigation of Hepatoprotective Activity of Induced Pluripotent Stem Cells in the Mouse Model of Liver Injury

To date liver transplantation is the only effective treatment for end-stage liver diseases. Considering the potential of pluripotency and differentiation into tridermal lineages, induced pluripotent stem cells (iPSCs) may serve as an alternative of cell-based therapy. Herein, we investigated the effect of iPSC transplantation on thioacetamide- (TAA-) induced acute/fulminant hepatic failure (AHF) in mice. Firstly, we demonstrated that iPSCs had the capacity to differentiate into hepatocyte-like cells (iPSC-Heps) that expressed various hepatic markers, including albumin, α-fetoprotein, and hepatocyte nuclear factor-3β, and exhibited biological functions. Intravenous transplantation of iPSCs effectively reduced the hepatic necrotic area, improved liver functions and motor activity, and rescued TAA-treated mice from lethal AHF. 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate cell labeling revealed that iPSCs potentially mobilized to the damaged liver area. Taken together, iPSCs can effectively rescue experimental AHF and represent a potentially favorable cell source of cell-based therapy

Prenatal diagnosis and molecular cytogenetic characterization of de novo partial monosomy 3p (3p26.3→pter) and partial trisomy 16q (16q23.1→qter)

AbstractObjectiveTo present the prenatal diagnosis and molecular cytogenetic characterization of a de novo unbalanced reciprocal translocation.Case ReportA 37-year-old woman, G3P1, underwent amniocentesis at 17 weeks of gestation because of her advanced maternal age. Her husband was 38 years old. Amniocentesis revealed a derivative chromosome 3 with the deletion of terminal 3p and the addendum of an unknown extra chromosomal segment on the distal 3p. The parental karyotypes were normal. Prenatal ultrasound findings were unremarkable. Array comparative genomic hybridization (aCGH) analysis using cultured amniocytes revealed a 2.38-Mb deletion in 3p26.3 [arr 3p26.3 (1-2,380,760)×1] encompassing 15 genes, which included 3 OMIM genes CHL1, CNTN6, and CNTN4, and a 13.17-Mb duplication in 16q23.1-q24.3 [arr 16q23.1q24.3 (76,999,082-90,170,596)×3] encompassing 207 genes, which included 81 OMIM genes. The pregnancy was subsequently terminated, and a malformed fetus was delivered with facial dysmorphism. Postnatal cord blood analysis revealed a karyotype of 46,XY,der(3)t(3;16)(p26.3;q23.1)dn. Polymorphic DNA marker analysis by quantitative fluorescent polymerase chain reaction (QF-PCR) on the DNAs extracted from the placenta and parental blood showed a paternal origin of the aberrant chromosome.ConclusionThe aCGH and QF-PCR analyses helped in delineating the genomic imbalance and parental origin of prenatally detected de novo unbalanced reciprocal translocation