Acute lower Limb Ischemia Caused by Fungal Infective Atrial Thrombus: A Case Report

Introduction: Septic thromboemboli have two consequences, ischemic and infection. In this paper we discuss a case with acute lower limb ischemia caused by fungal infective atrial thrombus. The patient underwent an anticoagulant therapy. Case presentation:                 A 43-year-old female patient who suffered from valvular heart disease (history of mitral and tricuspid valve replacement) was referred to the vascular surgery department of Modarres hospital with acute left limb ischemia. She underwent a successful emergency surgical thrombectomy. The pathological report of thrombus demonstrated fungal infection.  Conclusion: After surgical thrombectomy to control the acute lower limb ischemia, antimicrobial treatment of septic emboli is necessary

COVID-19-Related Spontaneous Pneumomediastinum: An Atypical Manifestation

COVID-19 is has been an emerging healthcare challenge during the last months. Herein we explain two cases with spontaneous pneumomediastinum as an atypical manifestation of COVID-19 disease; these two patients had confirmed COVID-19, leading to spontaneous pneumodeiastimun as an atypical manifestation during the course of hospital stay, presenting by abrupt deterioration in O2 saturation and symptoms. Spontaneous pneumomediastinum should be considered as a potential reason for the disease exacerbation in patients without previous history of mechanical ventilation. &nbsp

The immunopathogenesis of Helicobacter pylori-induced gastric cancer: a narrative review

Helicobacter pylori infection is a well-established risk factor for the development of gastric cancer (GC). Understanding the immunopathogenesis underlying this association is crucial for developing effective preventive and therapeutic strategies. This narrative review comprehensively explores the immunopathogenesis of H. pylori-induced GC by delving into several key aspects, emphasizing the pivotal roles played by H. pylori virulence factors, including cytotoxin-associated gene A (cagA) and vacuolating cytotoxin A (vacA), blood group antigen-binding adhesin (babA), and sialic acid binding adhesin (sabA). Moreover, the review focuses on the role of toll-like receptors (TLRs) and cytokines in the complex interplay between chronic infection and gastric carcinogenesis. Finally, the study examines the association between H. pylori evasion of the innate and adaptive immune response and development of GC. A comprehensive understanding of the immunopathogenesis of H. pylori-induced GC is essential for designing targeted interventions to prevent and manage this disease. Further research is warranted to elucidate the intricate immune responses involved and identify potential therapeutic targets to improve patient outcomes