1 research outputs found
Π‘ΠΈΠ½ΡΠ΅Π· ΠΈ Π°Π½ΡΠΈΠ±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½Π°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠ΅ΡΡΠ°Π·ΠΎΠ»ΡΠ½ΡΡ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ Ρ ΠΈΡΠΈΠ½Π°
The present study is devoted to the synthesis and study of the antibacterial activity in vitro of new tetrazole derivatives of natural polymer chitin of high, medium and low molecular weights with high, medium and low degree of substitution. The results showed that the obtained tetrazole derivatives are characterized by pronounced antibacterial activity in vitro against both S. aureus and E. coli strains. Among all derivatives, the highest antibacterial activity is demonstrated by a tetrazole derivative of chitin of moderate molecular weight and moderate degree of substitution. The antibacterial activity of this derivative as measured by the zone of inhibition of bacterial growth is comparable to the antibacterial activity of reference antibiotics ampicillin and gentamicin.ΠΠ°ΡΡΠΎΡΡΠ΅Π΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΡΠ²ΡΡΠ΅Π½ΠΎ ΡΠΈΠ½ΡΠ΅Π·Ρ ΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ Π°Π½ΡΠΈΠ±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ in vitro Π½ΠΎΠ²ΡΡ
ΡΠ΅ΡΡΠ°Π·ΠΎΠ»ΡΠ½ΡΡ
ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ
ΠΏΡΠΈΡΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ° Ρ
ΠΈΡΠΈΠ½Π° Π²ΡΡΠΎΠΊΠΈΡ
, ΡΡΠ΅Π΄Π½ΠΈΡ
ΠΈ Π½ΠΈΠ·ΠΊΠΈΡ
ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΡ
ΠΌΠ°ΡΡ Ρ Π²ΡΡΠΎΠΊΠΈΠΌΠΈ, ΡΡΠ΅Π΄Π½ΠΈΠΌΠΈ ΠΈ Π½ΠΈΠ·ΠΊΠΈΠΌΠΈ ΡΡΠ΅ΠΏΠ΅Π½ΡΠΌΠΈ Π·Π°ΠΌΠ΅ΡΠ΅Π½ΠΈΡ. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅ΡΡΠ°Π·ΠΎΠ»ΡΠ½ΡΠ΅ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΡΡ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΠΉ Π°Π½ΡΠΈΠ±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ in vitro Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ S. aureus ΠΈ E. coli. Π‘ΡΠ΅Π΄ΠΈ Π²ΡΠ΅Ρ
ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ
Π½Π°ΠΈΠ±ΠΎΠ»ΡΡΠ΅ΠΉ Π°Π½ΡΠΈΠ±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ΅ΡΡΡ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΠΎΠ΅ Ρ
ΠΈΡΠΈΠ½Π° ΡΡΠ΅Π΄Π½Π΅ΠΉ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠΉ ΠΌΠ°ΡΡΡ ΡΠΌΠ΅ΡΠ΅Π½Π½ΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ Π·Π°ΠΌΠ΅ΡΠ΅Π½ΠΈΡ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π½Π°Ρ ΠΏΠΎ Π·ΠΎΠ½Π΅ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠΎΡΡΠ° Π±Π°ΠΊΡΠ΅ΡΠΈΠΉ Π°Π½ΡΠΈΠ±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½Π°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΡΠΎΠΏΠΎΡΡΠ°Π²ΠΈΠΌΠ° Ρ Π°Π½ΡΠΈΠ±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ Π°Π½ΡΠΈΠ±ΠΈΠΎΡΠΈΠΊΠΎΠ² Π°ΠΌΠΏΠΈΡΠΈΠ»Π»ΠΈΠ½Π° ΠΈ Π³Π΅Π½ΡΠ°ΠΌΠΈΡΠΈΠ½Π°