3 research outputs found

    Psychometric feature of the child and parent versions of psychological inflexibility in pain scale (PIPS) in children with chronic pain and their parents

    Get PDF
    Background: The aim of this study was to investigate the validity, reliability and factor structure of the child and parent's version of psychological inflexibility in pain scale (PIPS) in the population of children with chronic pain and their parents. Methods: The sample consisted of 112 pairs of children and parents, selected through available sampling method from the Tehran Children's Hospitals. The PIPS questionnaire along with KIDScreen scale (to measure well-being), Child Behavior Checklist (CBCL) (the Youth Self-Report (YSR)) (to measure negative mood) and Visual Analogous Scale (VAS) (to measure pain severity) was implemented on them. Results: The reliability results of PIPS showed that the Cronbach's alpha for the child and parent versions was 0.66 and 0.82, respectively. In addition, the rerun correlation of child and parent versions was significant and acceptable, ranging from 0.47 to 0.78. Moreover, the highest correlation between PIPS dimensions in two versions of the child and parent was 0.89 and 0.92, respectively. The convergent and divergent validity of the PIPS showed that this questionnaire had a negative and significant correlation with the KID Screen scale and had a positive and significant correlation with the CBCL, YSR and VAS. Conclusions: The results of the exploratory factor analysis of this questionnaire revealed new factors. The exploratory factor analysis of child version indicated four factors (the factors 1, 3 and 4 are related to avoidance, and factor 2 measures the fusion) and in the confirmation factor analysis, the good fitting of these new factors was confirmed

    Risk of COVID-19 after natural infection or vaccinationResearch in context

    No full text
    Summary: Background: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection. Methods: In this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous infection/vaccine; and previous infection/vaccine. The main outcome was RT-PCR-confirmed COVID-19 >7–15 days (per original protocols) after final study injection. We calculated crude and adjusted efficacy measures. Findings: Previous infection/placebo participants had a 92% decreased risk of future COVID-19 compared to no previous infection/placebo participants (overall hazard ratio [HR] ratio: 0.08; 95% CI: 0.05–0.13). Among single-dose Janssen participants, hybrid immunity conferred greater protection than vaccine alone (HR: 0.03; 95% CI: 0.01–0.10). Too few infections were observed to draw statistical inferences comparing hybrid immunity to vaccine alone for other trials. Vaccination, previous infection, and hybrid immunity all provided near-complete protection against severe disease. Interpretation: Previous infection, any hybrid immunity, and two-dose vaccination all provided substantial protection against symptomatic and severe COVID-19 through the early Delta period. Thus, as a surrogate for natural infection, vaccination remains the safest approach to protection. Funding: National Institutes of Health
    corecore