PHARMACOTHERAPY OF HEART FAILURE

Abstract Heart failure is one of the major problems related to heart diseases in the modern era. Multiple comorbidities like coronary artery disease, hypertension, diabetes mellitus, anemia etc. have a great contribution in the development of heart failure.It is primarily two types systolic and diastolic heart failure. Insufficient or decreased pumping of the heart is Systolic heart failure whereas diastolic heart failure is because of lack of ability of the heart to relax or increased muscle inflexibility. The pathophysiology of heart failure is due to enhanced activity of sympathetic system, Renin Angiotensin system and structural changes in the wall of ventricle. The two definite targets of medical treatment in heart failure are: (1) Alleviation of obstructive (or) decreased output manifestations and replenishment of cardiac function. The drugs used are Frusemide, thiazides,ACE inhibitors/ARBs,Amrinone/Milrinone,Dopamine/ Dobutamine,Levosimendan,Digoxin, Hydralazine,Nitroprusside, Nitrate, Bisoprolol,Metoprolol, Nebivolol, Carvedilol (2) Prevention ofadvancementof heart failure and extension of patient survival - drugs used are β blockers,ACE inhibitors/ ARBs, Spironolactone andEplerenon

Optimization Of Hydrocarbon Ejector Using Computational Fluid Dynamics

Ejector is a powerful emerging thermo-compressor, which is more effective when used with hydrocarbon refrigerants because of its unique thermophysical properties. Therefore, in the present work, a steam ejector model is designed and validated with experimental results to evaluate its accuracy, followed by a detailed comparative study of hydrocarbons and synthetic refrigerants namely pentane, propane, butane, iso-butane, R1234-ze and R1234-yf by computational fluid dynamics and literature Review. The effectiveness of both classes of refrigerants is measured through entrainment ratio, critical backpressure, and thermophysical properties (Literature Review). Pentane was selected as a working fluid since it has comparatively high combination of entrainment ratio and critical back pressure with refrigeration compatible properties. Lastly, the optimized geometry was simulated by varying diameter of constant area zone, nozzle exit position and nozzle expansion angle through Computational Fluid dynamics. The simulation results provide insight into shockwaves, boundary layer separation, vortex formation of ejector flow

PHARMACOTHERAPY OF HEART FAILURE

Abstract Heart failure is one of the major problems related to heart diseases in the modern era. Multiple comorbidities like coronary artery disease, hypertension, diabetes mellitus, anemia etc. have a great contribution in the development of heart failure.It is primarily two types systolic and diastolic heart failure. Insufficient or decreased pumping of the heart is Systolic heart failure whereas diastolic heart failure is because of lack of ability of the heart to relax or increased muscle inflexibility. The pathophysiology of heart failure is due to enhanced activity of sympathetic system, Renin Angiotensin system and structural changes in the wall of ventricle. The two definite targets of medical treatment in heart failure are: (1) Alleviation of obstructive (or) decreased output manifestations and replenishment of cardiac function. The drugs used are Frusemide, thiazides,ACE inhibitors/ARBs,Amrinone/Milrinone,Dopamine/ Dobutamine,Levosimendan,Digoxin, Hydralazine,Nitroprusside, Nitrate, Bisoprolol,Metoprolol, Nebivolol, Carvedilol (2) Prevention ofadvancementof heart failure and extension of patient survival - drugs used are β blockers,ACE inhibitors/ ARBs, Spironolactone andEplerenon