Entrepreneurs, institutional entrepreneurship and institutional change

The intersection of entrepreneurship research and institutional theory has begun to attract increasing scholarly attention. While much recent research has studied "institutional entrepreneurs" credited with creating new or transforming existing institutions to support their projects, less attention has been paid to the institutions that constitute the menus from which cho

Chemically cross-linked poly(acrylic-co-vinylsulfonic) acid hydrogel for the delivery of isosorbide mononitrate.

We report synthesis, characterization, and drug release attributes of a series of novel pH-sensitive poly(acrylic-co-vinylsulfonic) acid hydrogels. These hydrogels were prepared by employing free radical polymerization using ethylene glycol dimethacrylate (EGDMA) and benzyl peroxide (BPO) as cross-linker and initiator, respectively. Effect of acrylic acid (AA), polyvinylsulfonic acid (PVSA), and EGDMA on prepared hydrogels was investigated. All formulations showed higher swelling at high pHs and vice versa. Formulations containing higher content of AA and EGDMA show reduced swelling, but one with higher content of PVSA showed increased swelling. Hydrogel network was characterized by determining structural parameters and loaded with isosorbide mononitrate. FTIR confirmed absence of drug polymer interaction while DSC and TGA demonstrated molecular dispersion of drug in a thermally stable polymeric network. All the hydrogel formulations exhibited a pH dependent release of isosorbide mononitrate which was found to be directly proportional to pH of the medium and PVSA content and inversely proportional to the AA contents. Drug release data were fitted to various kinetics models. Results indicated that release of isosorbide mononitrate from poly(AA-co-VSA) hydrogels was non-Fickian and that the mechanism was diffusion-controlled

Overcoming inaction through collective institutional entrepreneurship

Studies on institutional change generally pertain to the agency-structure paradox or the ability of institutional entrepreneurs to spearhead change despite constraints. In many complex fields, however, change also needs cooperation from numerous dispersed actors. This presents the additional paradox of ensuring that these actors engage in collective action when individual interests favor lack of cooperation. We draw on complementary insights from institutional and regime theories to identify drivers of collective institutional entrepreneurship and develop an analytical framework. This is applied to the field of global climate policy to illustrate how collective inaction was overcome to realize a global regulatory institution, the Kyoto Protocol

Text me! New consumer practices and change in organizational fields

While scholars have provided increasingly well-developed theoretical frameworks for understanding the role of institutional entrepreneurs and other purposeful actors in bringing about change in organizational fields, much less attention has been paid to the role of unorganized, nonstrategic actors in catalyzing change. In particular, the role of consumers remains largely uninvestigated. In this article, we draw on a case of the introduction of text messaging in the United Kingdom to explore the role of consumers in catalyzing change in organizational fields. Text messaging has become a widely diffused and institutionalized communication practice, in part changing mobile telephony from a voice-based, aural, and synchronous experience to a text-based, visual, and asynchronous experience. As consumers innovated and diffused new practices around this product, their actions led to significant changes in the field. We suggest how and under what conditions consumers are likely to innovate at the micro level and, with the subsequent involvement of other actors, catalyze change at the field level. Our primary contribution is to show how the cumulative effect of the spontaneous activities of one important and particularly dispersed and unorganized group can lead to changes in a field. By showing how change can result from the uncoordinated actions of consumers accumulating and converging over time, we provide an alternative explanation of change in organizational fields that does not privilege purposeful actors such as institutional entrepreneurs

Inter-Generational Transitions in Technological Ecosystems: The Case of Mobile Telephony

Many technology studies have conceptualized transitions between technological generations as a series of S-curve performance improvements over time. Surprisingly, the interregnum between successive technological generations has received little attention. To understand what happens in the interregnum, we build upon a framework of technological change as happening within an ecosystem that is characterized by both momentum and inertia. Applying this framework to study the mobile communications ecosystem, we found that the transition between 2G to 3G wireless was far from sequential. Different parts of the ecosystem evolved at different rates exerting both inertia and momentum with 'collateral technologies' playing an important role in shaping the transition path that unfolded. Based on this study we suggest that, rather than a distinct or unitary shift from an old to a new technology, transitions proceed in a zigzag manner resulting in the emergence of hybrid technologies. These processes hold implications for both theory and practice that we explore in this paper

Enduring Resilience of Capitalist Power: The Role of Capitalist Education as a Technology of Governance

Capitalism has experienced several crises since its emergence but its present global dominance apparently remains unassailable. This paper argues that capitalism’s resilience is grounded in the systemic hegemony of capitalist individuality—an individuality, committed to freedom as an ultimate end and seeking abundance in this world. It has been argued that the successful manufacturing of capitalist subjectivity is significantly dependent on the inculcation of capitalist values to the subject of capital through capitalist education. Section one focuses on freedom as capitalism’s telos and sketches the historical emergence of capitalist subjectivity formed by processes of capitalist governance. Section two investigates the formational role of capitalist education as a technology of capitalist governance. It analyzes capitalist education as a means for the construction of capitalist individuality. Section three argues that capitalism’s main antagonists, especially Marxist socialism, cannot effectively challenge capitalist hegemony in the lifeworld or at the level of the state because they (i.e. main antagonists) endorse freedom (the core capitalist value) as an ultimate end in itself. Socialism does not propose to alter the subjectivity of an individual that the capitalist education constructs

How are practices made to vary? Managing practice adaptation in a multinational corporation

Research has shown that management practices are adapted and ?made to fit? the specific context into which they are adopted. Less attention has been paid to how organizations anticipate and purposefully influence the adaptation process. How do organizations manage the tension between allowing local adaptation of a management practice and retaining control over the practice? By studying the adaptation of a specialized quality management practice ? ACE (Achieving Competitive Excellence) ? in a multinational corporation in the aerospace industry, we examine how the organization manages the adaptation process at the corporate and subsidiary levels. We identified three strategies through which an organization balances the tension between standardization and variation ? preserving the ?core? practice while allowing local adaptation at the subsidiary level: creating and certifying progressive achievement levels; setting discretionary and mandatory adaptation parameters; and differentially adapting to context-specific and systemic misfits. While previous studies have shown how and why practices vary as they diffuse, we show how practices may diffuse because they are engineered to vary for allowing a better fit with diverse contextual specificities

Fiddling while the ice melts? How organizational scholars can take a more active role in the climate change debate

The debate over anthropogenic climate change or the idea that human activities are altering the physical climate of the planet continues to rage amid seemingly irreconcilable differences, both within the developed world and between developed and less developed countries. With high uncertainty, rival worldviews, and wide diversity of meaning attached to the expression, climate change has become a key narrative within which local and transnational issues – economic, social, and political – are framed and contested. The field is fraught with controversies regarding causes and consequences, as well as different attitudes toward risks, technologies, and economic and social well-being for different groups. Parties also dispute how to share responsibility for reducing emissions – whether the issue primarily needs market, regulatory, technological, or behavioral solutions. Climate change is many things to many people. Competing interests negotiate over its interpretation and utilize various strategies to promote practices that advance their own understandings regarding climate change and its governance

EVALUATION OF EFFICACY AND SAFETY OF NIGELLA SATIVA OIL SUPPLEMENTATION IN PATIENTS OF CHRONIC KIDNEY DISEASE

ABSTRACTObjective: To evaluate efficacy and safety of add-on therapy of Nigella sativa oil in patients of stage 3 and 4 of chronic kidney disease (CKD).Materials and Methods: The study was conducted in a tertiary care center of north India in stage 3 and 4 patients of CKD. It was a prospective,comparative, and open label study. Patients were randomly divided into two interventional groups. Group I (Control) received conservativemanagement of CKD while Group II (Test) received conservative management along with N. sativa oil (2.5 mL, per orally, once daily) for 12 weeks.Hemogram and renal function tests were done, and adverse events were recorded at 0, 6, and 12 weeks of treatment.Results: After 12 weeks of treatment, there was a progressive improvement in clinical features and biochemical parameters in both the groups, but itwas more marked in the test group compared to control group. Both groups showed gradual improvement in the biochemical parameters as comparedto their pre-treated values which were more marked in N. sativa oil supplemented group. There was a reduction in blood glucose, blood urea, serumcreatinine, and 24-hr total urine protein. There was an increase in hemoglobin, 24-hr total urine volume, and glomerular filtration rate.Conclusion: N. sativa oil supplementation along with conservative management is efficacious and safe in averting the progression of disease in stage 3and 4 patients of CKD.Keywords: Chronic kidney disease, Nigella sativa oil, End-stage renal disease, Glomerular filtration rate