Impact of Proactive Personality on Career Adaptability and Their Intentions for Expatriate

Career decision-making is the biggest priority in an individual’s life and needs to be adapted more rigorously than anything else. Therefore, it is imperative to look for those factors that can have an influence on career adaptability. Guided by career construction theory, this research study explores the impact of proactive personality on career adaptability. This study examines the mediating effect of resilience between proactive personality and career adaptability, and the mediating effect of cultural intelligence between intentions on expatriate career and career adaptability, and the moderating role of gender between intentions for an expatriate career and career adaptability. The study revealed interesting insights in relation to career adaptability and intention for an expatriate career

Science, Technology and Innovation through Entrepreneurship Education in the United Arab Emirates (UAE)

The purpose of this study is to investigate the ways of achieving Science, Technology and Innovation (STI) in UAE. Previously, sustainability within an entrepreneurship context has been related to economic viability as opposed to sustainability in its broadest sense. Through a survey research method, we have highlighted the effects of three independent variables and two intervening variables on three important outcomes, innovation, need for achievement and motivation, which ultimately contributes towards STI. These data have been collected from the students of a well-known university in Al-Ain, UAE. The responses of 251 students have been utilized for analysis. For hypotheses testing, we used AMOS 18 (Structural Equation Modeling) and SPSS 20. The study revealed that all of the predictors have a strong effect on the outcome variables, which leads to STI in UAE. There is a strong need to revise the curriculum of higher education institutions of UAE to develop self-confidence, locus of control and risk taking propensity among students. The study provides novel insight into entrepreneurship education and serves as an initial benchmark in the field

Science, Technology and Innovation through Entrepreneurship Education in the United Arab Emirates (UAE)

The purpose of this study is to investigate the ways of achieving Science, Technology and Innovation (STI) in UAE. Previously, sustainability within an entrepreneurship context has been related to economic viability as opposed to sustainability in its broadest sense. Through a survey research method, we have highlighted the effects of three independent variables and two intervening variables on three important outcomes, innovation, need for achievement and motivation, which ultimately contributes towards STI. These data have been collected from the students of a well-known university in Al-Ain, UAE. The responses of 251 students have been utilized for analysis. For hypotheses testing, we used AMOS 18 (Structural Equation Modeling) and SPSS 20. The study revealed that all of the predictors have a strong effect on the outcome variables, which leads to STI in UAE. There is a strong need to revise the curriculum of higher education institutions of UAE to develop self-confidence, locus of control and risk taking propensity among students. The study provides novel insight into entrepreneurship education and serves as an initial benchmark in the field

Long Span DNA Paired-End-Tag (DNA-PET) Sequencing Strategy for the Interrogation of Genomic Structural Mutations and Fusion-Point-Guided Reconstruction of Amplicons

10.1371/journal.pone.0046152PLoS ONE79

Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. Wasting decreased overall across LMICs between 2000 and 2017, from 8.4% (62.3 (55.1–70.8) million) to 6.4% (58.3 (47.6–70.7) million), but is predicted to remain above the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025. Prevalence of overweight increased from 5.2% (30 (22.8–38.5) million) in 2000 to 6.0% (55.5 (44.8–67.9) million) children aged under 5 years in 2017. Areas most affected by double burden of malnutrition were located in Indonesia, Thailand, southeastern China, Botswana, Cameroon and central Nigeria. Our estimates provide a new perspective to researchers, policy makers and public health agencies in their efforts to address this global childhood syndemic

Science, Technology and Innovation through Entrepreneurship Education in the United Arab Emirates (UAE)

The purpose of this study is to investigate the ways of achieving Science, Technology and Innovation (STI) in UAE. Previously, sustainability within an entrepreneurship context has been related to economic viability as opposed to sustainability in its broadest sense. Through a survey research method, we have highlighted the effects of three independent variables and two intervening variables on three important outcomes, innovation, need for achievement and motivation, which ultimately contributes towards STI. These data have been collected from the students of a well-known university in Al-Ain, UAE. The responses of 251 students have been utilized for analysis. For hypotheses testing, we used AMOS 18 (Structural Equation Modeling) and SPSS 20. The study revealed that all of the predictors have a strong effect on the outcome variables, which leads to STI in UAE. There is a strong need to revise the curriculum of higher education institutions of UAE to develop self-confidence, locus of control and risk taking propensity among students. The study provides novel insight into entrepreneurship education and serves as an initial benchmark in the field

Arzberger P: Grid Portal Interface for Interactive Use and Monitoring of High-Throughput Proteome Annotation

Abstract. High-throughput proteome annotation refers to the activity of extracting information from all proteins in a particular organism using bioinformatics software on a high performance computing platform such as the grid. The Encyclopedia of Life (EOL) project [1] aims to catalog all proteins in all species for public benefits using an Integrative Genome Annotation Pipeline [2] (iGAP). The intrinsic complexity of the pipeline makes iGAP an ideal life sciences application to drive grid software development. It is a flagship application for the TeraGrid project [3]. The deployment of iGAP on the grid using grid middleware and mediator software has been described previously [4]. The heterogeneous and distributed computing environment on the grid requires an interactive user interface where jobs may be submitted and monitored. Here we describe our international collaborative effort in creating a gri

RNA at the epicentre of human development

The engineering of skeletal muscle requires platforms that facilitate the proliferation and maintenance of primary muscle stem cells (myoblasts) and muscle fibre maturation in a manner that reflects native muscle structure. We have been investigating the use of nanostructured conducting polymer surfaces for the orientation and electrical stimulation of cells and tissues and have developed a hybrid conducting polymer and carbon nanotube plaform, suitable for ex vivo muscle growth, differentiation and electrical stimulation. In this study, Carbon nanotube fibres were laid down in parallel on gold coated mylar. Layers of polypyrrole (doped with pTS) were galvinostatically grown over the carbon nanotube fibre mats to create a nanostructured polypyrrole surface. Myoblasts extracted from 8&#8201;week old mice were seeded onto polymer platforms and induced to differentiate into myotubes. Analysis of myofibre differentiation and orientation was then performed. In addition, total RNA was harvested from myotubes that had undergone bipolar electrical stimulation on the platforms 8 hours a day, for 3&#8201;days. Whole genome arrays (Codelink) were then used to assess gene expression changes in the electrically stimulated myotubes. Platforms were developed to encourage the alignment and differentiation of skeletal muscle stem cells (myoblasts) to reflect the orientation of mature skeletal muscle. Nanostructured platforms were created by orientation of carbon nanotube fibres on a conducting gold mylar surface, over which a layers of conductive polypyrrole were deposited. Human and murine myoblasts could be grown and differentiated on these platforms without the use of cell adhesion molecules. A significant increase in myotube orientation was seen on nanostructured surfaces, i.e. polypyrrole films with an underlying layer of orientated carbon nanotube fibres. This orientation decreased with increasing thickness of the polypyrrole, suggesting a strong influence of the nanostructure on the orientation of myofibres. In addition, a significant number of gene expression changes were detected in myofibres electrically stimulated on the platforms. A number of these genes were associated with muscle differentiation and myoblast fusion, demonstrating that these platforms can be used to influence the differentiation state of skeletal myoblasts through electrical stimulation. These studies demonstrate that novel hybrid platforms can be used to influence skeletal muscle differentiation ex vivo, through electrical stimulation. In addition these platforms can influence muscle fibre orientation in a manner reflecting the in vivo architecture of the parent tissue. Such platforms have application for controlling the regeneration of skeletal muscle in vivo and for the integration of bionic devices designed to facilitate muscle regeneration and function

Whole-genome reconstruction and mutational signatures in gastric cancer.

BACKGROUND: Gastric cancer is the second highest cause of global cancer mortality. To explore the complete repertoire of somatic alterations in gastric cancer, we combined massively parallel short read and DNA paired-end tag sequencing to present the first whole-genome analysis of two gastric adenocarcinomas, one with chromosomal instability and the other with microsatellite instability. RESULTS: Integrative analysis and de novo assemblies revealed the architecture of a wild-type KRAS amplification, a common driver event in gastric cancer. We discovered three distinct mutational signatures in gastric cancer--against a genome-wide backdrop of oxidative and microsatellite instability-related mutational signatures, we identified the first exome-specific mutational signature. Further characterization of the impact of these signatures by combining sequencing data from 40 complete gastric cancer exomes and targeted screening of an additional 94 independent gastric tumors uncovered ACVR2A, RPL22 and LMAN1 as recurrently mutated genes in microsatellite instability-positive gastric cancer and PAPPA as a recurrently mutated gene in TP53 wild-type gastric cancer. CONCLUSIONS: These results highlight how whole-genome cancer sequencing can uncover information relevant to tissue-specific carcinogenesis that would otherwise be missed from exome-sequencing data