STUDY THE POTENTIAL ANTIOXIDANT EFFECT OF VITAMIN D3 SUPPLEMENTATION ON THE LEVEL OF EXTRACELLULAR SUPEROXIDE DISMUTASE IN ASTHMATIC PATIENTS

Objective: This study was designed to evaluate the potential antioxidant effect of vitamin D3 supplementation in chronic asthma patients.Methods: A total of 44 candidate patients were diagnosed with asthma allocated as Group 1 includes 20 patients assigned to receive conventional therapy for asthma and Group 2 includes 24 patients assigned to receive conventional therapy for asthma plus 2000 IU vitamin D3 tablet for 3-month period. Furthermore, 30 apparently healthy subjects were included in the study as a control group. Pulmonary function test, serum 25-hydroxy vitamin D levels, serum extracellular superoxide dismutase (SOD3) levels were measured before and after 3 months therapy.Results: The mean forced expiratory volume in 1 second (FEV1) both the measured and the percentage of predicted value showed a highly significant increase after 3 months treatment compared to pre-treatment value in both study groups (p<0.01). When compared to pre-treatment value, there was no significant increase in forced expiratory volume in one second to forced vital capacity ratio (FEV1/FVC) in Group 1 (p>0.05), nevertheless, Group 2 showed highly significant increase after 3 months (p<0.01). Approximately, 90-96% of adult asthmatic patients revealed vitamin D deficiency (<20 ng/ml). Post-treatment with adjuvant vitamin D3 therapy, 25% of patients obtained acceptable level of vitamin D sufficiency (≥30 ng/ml). After 3 months of the treatment, Group 1 patients showed a significant decrease in mean SOD3 level compared to pre-treatment level (p<0.05), while Group 2 patients showed a significant increase in mean SOD3 level compared to pre-treatment level (p<0.05).Conclusion: Most of the asthmatic patients revealed vitamin D deficiency and supplementation with vitamin D3 reduce oxidative stress burden in those patients

QUANTITATIVE SEISMIC INTERPRETATION AND ROCK PHYSICS ANALYSIS FOR FIELD X

Resistivity plays a critical part in discovering hydrocarbons. Hydrocarbons are almost infinitely resistant. Clastic rock bodies had been seen to show a low resistivity and low difference responds. One of the variables adding to this is bioturbated sand. The resisitivity responds of this zone is similar to a water-bearing zones. This study is centered around examination of clastic rock bodies which includes the bypass zone, otherwise known as bioturbated sand layers.The scope of this research is to complete first phase of Final Year Project which is collecting data and samples. Field works and laboratory experiments will be conducted for this investigation.Second phase of the research includes laboratory methods to do comparative analysis for the acoustic and elastic properties from the samples and from Field X. Physical properties of the rock are recorded and observed its implication towards the waves velocity. Understanding this will enable is to interpret whether the rock body is capable of conducting acoustic waves efficiently and the factors causing the wave motion to be disturbed. In addition to that, as a requirement for students whom are majoring in basin studies, a geological map need to be constructed. The area of interest is Seri Iskandar, Perak

Kajian Kesan Adid Terhadap Bahan Logam-Kes Plat Aluminium

Pencemaran udara yang semakin meningkat di negara ini mengakibatkan kesan yang pelbagai keatas setiap objek di muka bumi, bukan sahaja ke atas hidupan malah ke atas bangunan. Oleh yang demikian bandar yang pesat membangun seperti Seberang Perai merupakan salah satu lokasi yang pelbagai aktiviti yang menyumbang kearah pencemaran. Tidak dapat dinafikan pelbagai aktiviti yang berlaku dalam urbanisasi suatu bandar bukan sahaja manusia malah ia urbanisasi ini melibatkan hidupan persekitaran lain. Pelbagai jenis hidupan akan bertambah mendiami kawasan urbanisasi sama ada secara semulajadi dan bukan semula jadi. Tetapi aktiviti manusia mengakibatbatkan pencemaran dan semua hidupan terpaksa menerima akibat yang sama contohnya hujan asid. Kajian ini dijalankan ke atas plat logam aluminuim untuk mengetahui kesannya oleh pH hujan asid. Aluminum merupakan logam nipis yang terhakis dengan kadar yang rendah berbanding logam-logam lain apabila terdedah . Melalui keputusan ini juga kesannya terhadap hidupan lain dapat disedari. Sekiranya aluminium terhakis apabila terdedah kepada hujan asid apatah lagi hidupan lain yang terdiri daripada sel-sel hidup. Perubahan kimia berlaku dengan cepat berbanding perubahan fizikal. Pendedahan keputusan kajian ini kepada pihak berkuasa akan lebih mendorong mereka bertindak mengawal kualiti alam sekitar

Efficacy of expressions of Arg-1, Hep Par-1, and CK19 in the diagnosis of the primary hepatocellular carcinoma subtypes and exclusion of the metastases

Many conflicts arise using immunohistochemistry of Hepatocellular carcinoma (HCC), some of these conflicts arise from the biliary part within the tumor itself or from liver metastasis. The aim of this study is to investigate the extent of Arg-1, HepPar-1, and CK-19 expressions in the primary HCC subtypes as well as studying of some metastatic cases to find a distinctive immunohistochemical panel utilizing it to differentiate between these entities. Material and methods. A paraffin-embedded block including 62 cases of primary HCC, and 18 cases diagnosed as metastatic tumors, were subjected for this study using Anti-liver Arginase antibody (ab125134 Cambridge, USA, polyclonal antibody, 3.75 µg/ml), HepPar-1 (polyclonal mouse antibody OCH1E5; 1:600; DAKO, CA, USA), and CK 19 Anti-Cytokeratin 19 antibody (ab15463, rabbit polyclonal antibody; 1:100; Cambridge, USA). The intensity of immunostaining was scored (0 to 3+). Nuclear and cytoplasmic staining with Arg-1 and cytoplasmic for both HepPar-1 and CK 19 are reported. Results. The histopathological patterns were mainly trabecular no=(24, 38.7%), and pseudoglandular (no=14, 22.5%), mixed hepatocellular cholangio-carcinoma was observed in one case (1.6%). Arginase-1 positivity was in 55 cases (88.7%) opposite to 46 (74.19%) and 8 (12.9%) for HepPAr.1% -1 and CK 19, respectively. The intensity of expression was marked in well and moderate differentiation for Arg-1 and HepPar-1and in poorly differentiated for CK 19. Metastatic carcinoma cases revealed two cases positive for Arg-1 (11.1%), 4 cases (22.2%) positive for HepPar-1, and 13 cases (72.2%) positive for CK 19. Conclusion. Arg-1 and HepPar-1 are confirmative in the diagnosis of primary HCC in most cases, either separately or collectively but the priority of selection leans more towards Arg-1. Arg-1 and HepPar-1 positive with negative CK 19 expressions give more support to diagnosis of primary HCC while the reverse will support the diagnosis of tumour of biliary origin or liver metastasis

QUANTITATIVE SEISMIC INTERPRETATION AND ROCK PHYSICS ANALYSIS FOR FIELD X

Resistivity plays a critical part in discovering hydrocarbons. Hydrocarbons are almost infinitely resistant. Clastic rock bodies had been seen to show a low resistivity and low difference responds. One of the variables adding to this is bioturbated sand. The resisitivity responds of this zone is similar to a water-bearing zones. This study is centered around examination of clastic rock bodies which includes the bypass zone, otherwise known as bioturbated sand layers.The scope of this research is to complete first phase of Final Year Project which is collecting data and samples. Field works and laboratory experiments will be conducted for this investigation.Second phase of the research includes laboratory methods to do comparative analysis for the acoustic and elastic properties from the samples and from Field X. Physical properties of the rock are recorded and observed its implication towards the waves velocity. Understanding this will enable is to interpret whether the rock body is capable of conducting acoustic waves efficiently and the factors causing the wave motion to be disturbed. In addition to that, as a requirement for students whom are majoring in basin studies, a geological map need to be constructed. The area of interest is Seri Iskandar, Perak

Thyroid, Renal, and Breast Carcinomas, Chondrosarcoma, Colon Adenomas, and Ganglioneuroma: A New Cancer Syndrome, FAP, or Just Coincidence

We are presenting a case associated with papillary thyroid carcinoma, renal cell carcinoma, invasive mammary carcinoma, chondrosarcoma, benign ganglioneuroma, and numerous colon adenomas. The patient had a family history of colon cancer, kidney and bladder cancers, lung cancer, thyroid cancer, leukemia, and throat and mouth cancers. She was diagnosed with colonic villous adenoma at the age of 41 followed by thyroid, renal, and breast cancers and chondrosarcoma at the ages of 48, 64, 71, and 74, respectively. Additionally, we included a table with the most common familial cancer syndromes with one or more benign or malignant tumors diagnosed in our case, namely, FAP, HNPCC, Cowden, Peutz-Jeghers, renal cancer, tuberous sclerosis, VHL, breast/other, breast/ovarian, Carney, Werner’s, Bloom, Li-Fraumeni, xeroderma pigmentosum, ataxia-telangiectasia, osteochondromatosis, retinoblastoma, and MEN2A

CLINICAL EVALUATION OF POTENTIAL ANTI-INFLAMMATORY EFFECT OF VITAMIN D3 ADJUVANT THERAPY FOR CHRONIC ASTHMA IN IRAQI PATIENTS

Objective: This study was designed to evaluate the potential anti-inflammatory effect of vitamin D3 supplementation in Iraqi patients with chronic asthma. Methods: Forty-four candidate patients were diagnosed with asthma during their visit to hospital allocated as 20 patients assigned to receive conventional therapy for asthma and 24 patients assigned to receive conventional therapy for asthma plus 2000 I. U vitamin D3 tablet for three months period. Also, 30 apparently healthy subjects were included in the study as a control group. Pulmonary function test, serum 25-OH vitamin D levels, serum Interlukin-10 (IL-10) levels, serum tumor necrosis factor alpha (TNF-α) levels were measured before and after three months therapy.Results: After three months treatment, there was a highly significant improvement in both measured and percentage of predicted value of pulmonary function test (PFT) compared to the pre-treatment value for both group 1 and group 2 patients (p<0.01). Also, a highly significant increase in total endogenous vitamin D level in group 2 when compared to group 1 patients after three months period (p<0.01). Group 2 patients presented with a significant increase in mean IL-10 after three months of treatment when compared to pre-treatment level (p<0.05). The mean TNF-α level was increased non-significantly in both study groups, but the higher level was found in group 1 patients than in group 2 patients when compared to pre-treatment level (p>0.05).Conclusion: There was a significant increase in the level of anti-inflammatory biomarker interleukin-10 (IL-10), though no clear effect on tumor necrosis factor-α (TNF-α) was noticed after three months treatment with vitamin D3 supplementation

Effect of some prepared superplasticizers on the rheological properties of oil well cement slurries

Three superplasticizers namely: cyclohexanone glyoxylic sulfanilate (CGS), acetone glyoxylic sulfanilate (AGS) and melamine glyoxylic sulfanilate (MGS) were prepared and characterized using FT-IR. The prepared admixtures were evaluated as additives for improving the rheological properties of oil well cement. The effect of temperature (25°, 45° and 65 °C) and admixture dose (0.25, 0.5, 0.75 and 1%) were determined on the apparent viscosity, plastic viscosity and yield stress. The results showed that the prepared superplasticizers, CGS, AGS and MGS decreased these parameters. The results concluded that the CGS, AGS and MGS admixtures act as retarders and dispersant for oil well cement. The three prepared admixtures exhibited high enhancement on the rheological properties which mean that it can use in oil cementing processes. Keywords: Superplasticizers, Rheological properties, Apparent viscosity, Plastic viscosity, Yield stres

Effect of some prepared superplasticizers (Cyclohexanone Based) on compressive strength and physico-chemical properties of oil well cement pastes

Two different superplasticizers particularly cyclohexanone formaldehyde sulfanilate (CFS) and cyclohexanone glyoxylic sulfanilate (CGS) were prepared; also, their effect on mechanical and physico-chemical properties of oil well cement was assessed. The chemical structures were affirmed by FTIR technique. The designed chemical compounds were predestined as superplasticizers for cement pastes. The pastes were made by superplasticizer (CFS or CGS) addition to cement by the ratios of 0, 0.25, 0.50, 0.75, and l.00 as mass% of cement. The water of consistency, setting time, chemically combined water content (Wn), the hydration rate and compressive strength of the admixed hardened pastes were predestined at various time periods. The phase composition was intended by DSC and XRD techniques. The results revealed that as the admixture dose rate increases the demand cement paste water of consistency decreases. Also, as the admixture addition rate increases the chemically combined water content decreases, so the rate of hydration decreases; meanwhile compressive strength magnitudes increase accounting for the low water/cement (initial porosity) of the sample