Oksidacijski stres, hematološko-biokemijski nalaz, elementi u tragovima i vitamini u pasa s cinkom izlječivom dermatozom.

The aim of this study was to examine the hemato-biochemical alterations and evaluate the oxidative stress indices in the blood of dogs with zinc responsive dermatosis. The study included 9 dogs with clinically established diagnosis of zinc responsive dermatosis and 6 dogs as a healthy control. The clinical disease was characterized by alopecia, erythema, hyperkeratotic foot pads and scaling around the eyes, chin, eyes, head and legs. The MDA levels were significantly (P<0.01) higher, whereas superoxide dismutase and catalase activity were significantly (P<0.01) lower when compared to healthy control dogs. Hematology revealed significant neutrophilia and lymphopenia, along with anemia. Biochemical examination revealed a significant (P<0.05) decrease in albumin, A:G ratio and glucose levels, and a significant increase (P<0.05) in globulin level. Plasma zinc, vitamin A and C were significantly decreased, however copper levels were increased. In conclusion, zinc responsive dermatosis is accompanied by oxidative stress and anemia, and affected animals are susceptible to infection.Istraživanje je provedeno radi određivanja hematološko-biokemijskih poremećaja i prosudbe pokazatelja oksidacijskog stresa u krvi pasa s cinkom izlječivom dermatozom. U istraživanje je bilo uključeno devet pasa s kliničkom dijagnozom dermatoze izlječive cinkom i šest zdravih kontrolnih pasa. Klinički se bolest očitovala alopecijom, eritemom, hiperkeratozom mekuši, ljuštenjem oko očiju, po bradi, glavi i nogama. Razine malondialdehida bile su značajno veće (P<0,01), dok je aktivnost superoksidne dismutaze i katalaze bila značajno manja (P<0,01) u usporedbi sa zdravom kontrolnom skupinom pasa. Hematološki nalazi pokazali su znatnu neutrofiliju, limfopeniju i anemiju. Biokemijskom pretragom ustanovljen je značajan pad koncentracije albumina (P<0,05), omjera A:G i razine glukoze te značajno povećanje razine globulina (P<0,05). Cink u plazmi, vitamin A i C bili su značajno smanjeni dok su razine bakra bile povećane. Zaključuje se da je dermatoza izlječiva cinkom također popraćena oksidacijskim stresom, anemijom, a zahvaćene životinje osjetljivije su na infekciju