Effect of vitamin C and vitamin E on lung contusion: A randomized clinical trial study

ABSTRACT There is association between lung contusion (lC) and a progressive in fl ammatory response. The protective effect of vitamin C and vitamin E, as strong free radical scavengers on favourite outcome of (LC) in animal models,has been confirmed. Design: to evaluate the effect of vitamins, E and C on arterial blood gas (ABG) and ICU stay, in (LC), with injury severity score (ISS) 18 ± 2, due to blunt chest trauma. Methods: This study was a randomized, double-blind, placebo controlled clinical trial. Patients with (ISS)18 ± 2 blunt chest trauma, who meet criteria, participated in the study. A total of 80 patients from Feb 2015 to Jun2018and were randomly divided into 4 groups. Patients received intravenous vitamin E (1000IU mg), was (group I);intravenous vitamin C (500) (group II). Vitamin C + vitamin E = (group III), and intravenous distilled water = (control group) or (group IV). ABG, serum cortisol, and CRP levels were determined at baseline, 24 h and 48 h after the intervention. Results: a significant decrease in ICU stay in group III compared to other groups (p < 0.001). Co-administration of vitamin C and vitamin E showed significant increases pH (values to reference range from acidemia”), oxygen pressure, and oxygen saturation in group III compared to other groups (p <0.001). A significant decrease in carbon dioxide pressure was also detected after receiving vitamin C and vitamin E in group III, compared to other groups (p < 0.001). There was no significant difference cortisol and CRP levels between groups after the intervention. Conclusion: Co-administration of vitamin C and vitamin E, improve the ABG parameters and reduce I

Effect of hybrid ultrasonic and mechanical stirring on the distribution of m-SiCp in A356 alloy

The present study details the micro-scale silicon carbide particle (m-SiCp) homogeneous distribution in an A356 alloy through hybrid ultrasonic-stirring melt treatment under different operation conditions. Ultrasonically excited fluids were studied by particle image velocimetry to estimate the efficiency of the acoustic streaming in different distances to the sonotrode. Distinct particle approaches to introduce the melt and stirring techniques were performed to determine a successful route to promote a homogenous distribution of reinforcement particles. Results showed that the addition of m-SiCp in the semisolid state significantly improved particle wettability, preventing rapid sedimentation. The combination of ultrasonic induced streaming and mechanical stirring is an effective tool for the homogeneous distribution of m-SiCp along the casting specimen.:This work was supported by PTDC/EMEEME/30967/2017 and NORTE-0145-FEDER-030967, co-financed by the European Regional Development Fund (ERDF), the Operational Program for Competitiveness and Internationalization (COMPETE 2020), under Portugal 2020, and by the Fundação para a Ciência e a Tecnologia—FCT I.P. national funds. Additionally, this work was supported by the Portuguese FCT under the reference project UIDB/04436/2020 and the Stimulus of Scientific Employment Application CEECIND/03991/2017

IoT Expunge: Implementing Verifiable Retention of IoT Data

The growing deployment of Internet of Things (IoT) systems aims to ease the daily life of end-users by providing several value-added services. However, IoT systems may capture and store sensitive, personal data about individuals in the cloud, thereby jeopardizing user-privacy. Emerging legislation, such as California's CalOPPA and GDPR in Europe, support strong privacy laws to protect an individual's data in the cloud. One such law relates to strict enforcement of data retention policies. This paper proposes a framework, entitled IoT Expunge that allows sensor data providers to store the data in cloud platforms that will ensure enforcement of retention policies. Additionally, the cloud provider produces verifiable proofs of its adherence to the retention policies. Experimental results on a real-world smart building testbed show that IoT Expunge imposes minimal overheads to the user to verify the data against data retention policies.Comment: This paper has been accepted in 10th ACM Conference on Data and Application Security and Privacy (CODASPY), 202

Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development.

BACKGROUND: We present the genome sequence of the tammar wallaby, Macropus eugenii, which is a member of the kangaroo family and the first representative of the iconic hopping mammals that symbolize Australia to be sequenced. The tammar has many unusual biological characteristics, including the longest period of embryonic diapause of any mammal, extremely synchronized seasonal breeding and prolonged and sophisticated lactation within a well-defined pouch. Like other marsupials, it gives birth to highly altricial young, and has a small number of very large chromosomes, making it a valuable model for genomics, reproduction and development. RESULTS: The genome has been sequenced to 2 × coverage using Sanger sequencing, enhanced with additional next generation sequencing and the integration of extensive physical and linkage maps to build the genome assembly. We also sequenced the tammar transcriptome across many tissues and developmental time points. Our analyses of these data shed light on mammalian reproduction, development and genome evolution: there is innovation in reproductive and lactational genes, rapid evolution of germ cell genes, and incomplete, locus-specific X inactivation. We also observe novel retrotransposons and a highly rearranged major histocompatibility complex, with many class I genes located outside the complex. Novel microRNAs in the tammar HOX clusters uncover new potential mammalian HOX regulatory elements. CONCLUSIONS: Analyses of these resources enhance our understanding of marsupial gene evolution, identify marsupial-specific conserved non-coding elements and critical genes across a range of biological systems, including reproduction, development and immunity, and provide new insight into marsupial and mammalian biology and genome evolution

Compression of Record and Handshake Headers for Constrained Environments

draft-raza-dice-compressed-dtls-00 This document describes header compression mechanisms for the Datagram Transport Layer Security (DTLS) [RFC6347] based on the encoding scheme standardized in [RFC6282]. The DTLS Record Header (RH), Handshake Header (HH), and optionally handshake message headers are compressed using Next Header Compression (NHC) defined in [RFC6282]. This document neither invalidates any encoding schemes proposed in 6LoWPAN [RFC6282] nor compromises the end-to-end security properties provided by DTLS. This document aims to increase the applicability of DTLS and, thus, CoAPs [draft-ietf-core-coap-18] in constrained environments. Status of this Memo This Internet-Draft is submitted in full conformance with the provisions of BCP 78 and BCP 79. Internet-Drafts are working documents of the Internet Engineering Task Force (IETF). Note that other groups may also distribute working documents as Internet-Drafts. The list of current Internet-Drafts is a