Design of a CMOS Differential Operational Transresistance Amplifier in 90 nm CMOS Technology

In this paper, a CMOS differential operational transresistance amplifier (OTRA) is presented. The amplifier is designed and implemented in a standard umc90-nm CMOS technology. The differential OTRA provides wider bandwidth at high gain. It also shows much better rise and fall time and exhibits a very good input current dynamic range of 50 to 50 μA. The OTRA can be used in many analog VLSI applications. The presented amplifier has high gain bandwidth product of 617.6 THz Ω. The total power dissipation of the presented amplifier is also very low and it is 0.21 mW

Eight-Port Metamaterial Loaded UWB-MIMO Antenna System for 3D System-in-Package Applications

In this article, an eight-elementultra-wideband (UWB) Multiple-Input-Multiple Output (MIMO) antenna system is proposed for 3D non-planar applications. The proposed UWB-MIMO antenna is installed around a polystyrene block in the 3D-octagonal arrangement. The eight radiating elements are placed on thesidesof the octagonalpolystyrene block with topand bottom surfaces left open. The single antenna element consists of a modified Y-shaped radiating patch, epsilon-negative (ENG) metamaterial,and a partial ground plane. A modified pie-shaped decoupling structure is deployed at the back-side of the radiating patch to improve the isolation amongarray elements. Each antenna element is printed on a low-cost FR-4 substrate with dimensions of 28 mm × 23 mm with coverage of the whole UWB spectrum from3.1 to 10.6 GHz frequency band. The eight-port UWB-MIMO antenna system consists of symmetric and non-symmetric array configurations.Simulated and measuredMIMO performance parameters i.e. Channel Capacity Loss (CCL) < 0.35, Envelope Correlation Coefficient (ECC) < 0.0025 and TotalActive Reflection Coefficient (TARC) < -11 dB are in acceptable limits for both symmetric and non-symmetric configurations. The proposed MIMO antenna system is suitable for 3D system-in-package, indoor localization systems, and wireless personal area network applications in industries where multiple machines are connected to a central server wirelessly through suchkindsof antennas in a rich scattering environmen

Hexagonal Shaped Near Zero Index (NZI) Metamaterial Based MIMO Antenna for Millimeter-Wave Application

A single-layered multiple-input multiple-output (MIMO) antenna working at 28 GHz loaded with a compact planar-patterned metamaterial (MTM) structures is presented in this paper for millimeter-wave application. A combination of a split square and hexagonal shaped unit cell is designed and investigated with a wide range of effective near-zero index (NZI) of permeability and permittivity, along with a refractive index (NZRI) property. The metamaterial characteristics were examined through the material wave propagation in two main directions at y and x-axis. For wave propagation at the y-axis, it demonstrates mu-near-zero (MNZ) with more than 6 GHz bandwidth, near-zero refractive index (NZRI), and epsilon-near-zero (ENZ) properties. However, it indicates a wide negative range of single mu metamaterial (MNG) from 27.6 to 28.9 GHz frequency span at x-axis wave propagation. A single antenna with 3 × 3 metamaterial unit cells is proposed to operate at a frequency band (24 - 30) GHz. Furthermore, MIMO antenna with only 4 mm space between antenna elements provides high isolation of more than 24 dB. The measured results show that the MIMO antenna is satisfied with 6 GHz bandwidth, and maximum peak gain of 12.4 dBi. In addition to that, the proposed MIMO antenna loaded with MTM has also shown good performances with high diversity gain (DG > 9.99), envelope correlation coefficient (ECC) lower than 0.0013, channel capacity loss (CCL) <; 0.42, total active reflection coefficient (TARC) <; -7 dB, total efficiencies of higher than 98%, with an overall antenna size of 52 mm × 23 mm

Evaluation of Hypoglycaemic Effects of Dipeptidyl Peptidase–4 Inhibitors and Biguanide on Type-2 Diabetic subjects: A six months trial

Objective: This trial was conducted to evaluate the effectiveness of oral hypoglycemic agents on diabetic control and biochemical parameters of known diabetic subjects. Introduction:&nbsp; T2DM&nbsp;&nbsp; occurs due to abnormal metabolism of carbohydrate, proteins and lipids leading to increased blood glucose characterized by polyuria and polydypsia due to relative 5deficiency or lack of insulin. Beside dietary control and insulin therapy, various oral hypoglycemic such as sulfonylurea biguanide, thiazolidinedione, DPP–4 inhibitors, glucagon–like peptide inhibitors and SGL2. &nbsp; Material and Methods: This comparative trial was carried out on previously diagnosed type–2 diabetic subjects. This trial was conducted at health care centers of District Nowshehra viz. NMC Nowshehra, DHQ Hospital Nowshehra, and ICS, Peshawar in collaboration with KMC and PIMC Peshawar, Khyber Pakhtunkhwa, Pakistan. A total of 200 known diabetic subjects were randomly recruited on the basis of predetermined selection criteria and were splited into two groups. Group A having 100 diabetic subjects was given DPP–4 inhibitor; Sitagliptin 50 mg two times a day alone for six (06) months while Group B comprising of 100 patients were treated &nbsp;&nbsp;with combination of DPP–4 inhibitor (Sitagliptin 50 mg 1BD) and Metformin in a dose of 500 mg two times a day. Venous blood samples were taken from each patient in both fasting (10–12 hour night long fast) and random (2 hour post prandial) state. FBS, RBS, HbA1C, S. creatinine and fasting S. lipid profile were determined by using spectrophotometric colorimetric methods using kits (procured from Elitech, Spain) at&nbsp; 03 and 06 months follow up. Inclusion criteria was subjects with T2DM of age 18 years and above. T2DM patients on insulin, diabetic nephropathy and retinopathy were excluded. The data was analyzed by using SPSS software version 20. Results: Significant results (p &lt; 0.05) were seen for glycemic control (FBS, RBS, HbA1C) in Group B as compare to Group A patients

In silico molecular characterization of TGF-β gene family in <i>Bufo bufo</i>: genome-wide analysis

Bufo bufo is a living example of evolutionary processes due to its numerous physiological and ecological adaptations. This is the first study to genetically characterize the TGF-β gene family in B. bufo at the genome-wide level, and a total of 28 TGF-β gene family homologs are identified. Physicochemical characteristics of TGF-β homologs exhibit a basic nature except for BMP1, BMP4, BMP10, BMP15, AMH, INHA, NODAL Modulator and TGFB1. Phylogenetic analysis divided the TGF-β gene family homologs into 2 major clades along with other vertebrate species. In domain and motif composition analysis, the gene structure for all TGF-β homologs exhibited homogeneity except BMP1. We have identified the TGF-β propeptide domain together with the TGF-β in all family homologs of TGF-β superfamily. Gene structure comparisons indicated that the TGF-β gene family have arisen by gene duplications. We also identified 10 duplicated gene pairs, all of which were detected to be segmental duplications. The Ka/Ks test ratio findings for every pair of genes revealed that none of the ratios surpassed 1 except for one gene pair (INHA/BMP1), indicating that these proteins are under positive selection. Circos analysis showed that TGF-β gene family homologs are arranged in 11 dispersed clusters and all were segmentally arrayed in the genome. This study provides a molecular basis for TGF-β ligand protein functional analysis and may serve as a reference for in-depth phylogenomics and may promote the development of novel strategies. Communicated by Ramaswamy H. Sarma</p

Polymorphism of the renalase gene in gestational diabetes mellitus

Renalase is considered as a novel candidate gene for type 2 diabetes. In this study, we aimed to investigate the relationship of serum renalase and two single nucleotide polymorphisms with gestational diabetes mellitus. One hundred and ninety-eight normotensive pregnant females (n=99 gestational diabetes mellitus; n=99 euglycemic pregnant controls) were classified according to the International Association of the Diabetes and Pregnancy Study criteria. Fasting and 2-h post glucose load blood levels and anthropometric assessment was performed. Serum renalase was measured using enzyme-linked immunosorbent assay, whereas DNA samples were genotyped for renalase single nucleotide polymorphisms rs2576178 and rs10887800 using Polymerase chain reaction-Restriction fragment length polymorphism method. In an age-matched case control study, no difference was observed in the serum levels of renalase (p\u3e0.05). The variant rs10887800 showed an association with gestational diabetes mellitus and remained significant after multiple adjustments (p\u3c0.05), whereas rs2576178 showed weak association (p=0.030) that was lost after multiple adjustments (p=0.09). We inferred a modest association of the rs10887800 polymorphism with gestational diabetes. Although gestational diabetes mellitus is self-reversible, yet presence of this minor G allele might predispose to metabolic syndrome phenotypes in near the future

Groundwater delineation for sustainable improvement and development aided by GIS, AHP, and MIF techniques

Exploration of groundwater is an integral part of viable resource growth for society, economy, and irrigation. However, uncontrolled utilization is mainly reported in urban and industries due to the increasing demand for water in semi-arid and arid regions of the world. In the background, groundwater demarcation for potential areas is vital in meeting necessary demand. The current study applied an integrated method comprising the analytical hierarchy process (AHP), multiple influence factors (MIF), combined with a linear regression curve and observatory well data for groundwater prospects mapping. Thematic maps such as flow direction, flow accumulation, elevation map, land use land cover, slope, soil texture, hill shade, geomorphology, normalized vegetation index, and groundwater depth map were generated utilizing remote sensing techniques. The relative weight of each parameter was estimated and then assigned to major and minor parameters. Potential zones for groundwater were classified into five classes, namely very good, good, moderate, poor, and very poor, based on AHP and MIF methods. A spatially explicit sensitivity and uncertainty analysis method to a GIS-based multi-criteria groundwater potential zone model is presented in this research. The study addressed a flaw in the way groundwater potential mapping results are typically presented in GIS-based multi-criteria decision analysis studies, where discrete class outputs are used without any assessment of their certainty with respect to variations in criteria weighting, which is one of the main contributors to output uncertainty. The study region is categorized based on inferred results as very poor, poor, marginal, and very good in potential ground quality 3.04 km2 is considered extremely poor, 3.33 km2 is considered poor, 64.42 km2 is considered very good, and 85.84 km2 is considered marginal zones, which shows reliable and potential implementation. The outcomes of AHP and MIF were validated by linear regression curve and actual water table in a study area. The study results help to formulate the potential demarcation of groundwater zones for future sustainable planning and development of groundwater sources. This study may be helpful to provide a cost-effective solution to water resources crises. The current study finding may be helpful for decision-makers and administrative professionals for sustainable management of groundwater resources for present and future demands.Validerad;2024;Nivå 2;2024-04-02 (signyg);Funder: King Saud University (RSP2024R351);Full text license: CC BY</p