Investigation of physico-chemical properties of drugs iron (III) hydroxide polymaltosate and iron protein succinylate

The purpose of the study is to study the physico-chemical properties of M iron (III) hydroxide polymaltosate and iron protein succinylate, such as the ability to dissociate, the hydrogen pH in various aqueous solutions, redox properties.Цель исследования – изучение физико-химических свойств ЛП железа (III) гидроксид полимальтозат и железа протеин сукцинилат, таких как способность к диссоциации, водородного показателя рН в различных водных растворах, окислительно-восстановительных свойств

Conformation-regulated mechanosensory control via titin domains in cardiac muscle

The giant filamentous protein titin is ideally positioned in the muscle sarcomere to sense mechanical stimuli and transform them into biochemical signals, such as those triggering cardiac hypertrophy. In this review, we ponder the evidence for signaling hotspots along the titin filament involved in mechanosensory control mechanisms. On the way, we distinguish between stress and strain as triggers of mechanical signaling events at the cardiac sarcomere. Whereas the Z-disk and M-band regions of titin may be prominently involved in sensing mechanical stress, signaling hotspots within the elastic I-band titin segment may respond primarily to mechanical strain. Common to both stress and strain sensor elements is their regulation by conformational changes in protein domains