Design, Development and Evaluation of Dendritic Architechture for the Delivery of Ofloxacin against Resistance Producing Strains

Dendrimer represents hyperbranched, monodisperse, three-dimensional macromolecules with host-guest entrapment properties having defined molecular weight. Dendrimer allows defined control of size, shape and position of functional groups. For the above said reason, dendrimers have become more popular application in many fields.The present study was aimed at developing and exploring the use of novel PEGylated 0.5G EDA-PPI (poly propyeleneimine) dendritic architecture for the delivery of an antibacterial drug, Ofloxacin. The dendritic architecture was synthesized by double Michael addiction reaction using ethylenediamine as a core moiety and the synthesized system was PEGylated using PEG-4000 and the Ofloxacin was loaded by equilibrium dialysis method into the system. The prepared Ofloxacin loaded PEGylated 0.5G EDAPPI dendritic architecture was evaluated for FTIR studies, solubility studies, drug entrapment efficiency, in-vitro drug release studies and anti-bacterial assay. The results showed that there was enhanced rate of drug release, drug solubility with significant antimicrobial activity compared to plain Ofloxacin. The tablets of Ofloxacin loaded PEGylated 0.5G EDA-PPI dendrimer were prepared by direct compression method and evaluated for various parameters such as hardness, thickness, weight variation, drug content and in-vitro drug release studies. The in-vitro drug release of Ofloxacin loaded 0.5G EDA-PPI dendrimer compared with that of marketed Ofloxacin tablet. The results revealed that there is enhanced rate of dissolution of Ofloxacin loaded PEGylated 0.5G EDA-PPI dendrimer than that of marketed Ofloxacin tablet formulation

Formulation and evaluation of controlled release matrix tablets of antihypertensive drug using natural and synthetic hydrophilic polymers

The present study is to prepare and evaluate controlled release matrix tablets of Losartan potassium using natural and synthetic polymers. Tablets were prepared by direct compression method using different drug: polymer concentration. Fourier Transform Infrared Spectroscopy (FT-IR) and Differential Scanning Calorimetry (DSC) study revealed no chemical interaction between drug and polymers used. Precompression and postcompression parameters complied with pharmacopoeial limit for the tablets. In-vitro release studies was performed and the results indicates that matrix tablet  (F9) containing 50% w/w blend of natural and synthetic polymer has better controlled release for a period of 24 h

Formulation and evaluation of fast disintegrating tablets of Granisetron HCl using natural polymers

The present research work is to formulate and evaluate fast disintegrating tablets of Ganisetron HCl using natural polymers. Tablets were prepared by direct compression method using different drug polymer concentration. Fourier Transform Infrared Spectroscopy (FT-IR) study revealed no chemical interaction between drug and polymers used. Precompression and postcompression parameters were within the limits for the tablets. Disintegration and dissolution data of tablets were directly proportional to the superdisintegrants concentration. Selected fast dissolving tablet F8 containing plantago ovate 5%w/w has released 99.66 % within 3min

Research studies on polymeric effect of indomethacine transdermal films

The objective of this study was to design and evaluate transdermal patches of Indomethacine using HPMC, EC and Eudragit RLPO using solvent casting technique. The in vitro drug release studies were performed by using the USP (paddle type) dissolution list apparatus in 1000 ml of 0.1N HCl (Medium Employed) at 37o C room temperature for an rpm maintained at 100 within a stipulated time interval of 15 minutes. The withdrawn Samples were analyzed by using UV visible  spectrophotometer at 268 mm using regent blank. The prepared  transdermal patches had undergone physic chemical evaluator parameters such as PMA, PML, swelling index, water vapour transmission rate, film thickness, weight cheek, and folding Endurance and drug content clearance. In vitro dissolution study of drug along with different  combination of polymers; i.e. HPMC, EC and Eudragit has been  performed; out of which batch B6 shows the best moisture of films and the graph representing the best controlled drug release. As the percentage of ethyl cellulose was reduced the rate of the release of the drug was increased. [Batch B6 > HPMC: EC: Eudragit RLPO - 2:1:2]. Films with batch  code B6 shows better stability and suitability. Higuchi’s plot revealed that the predominant Mechanism of drug release was diffusio

Development and Optimization of Cubosomal Econazole Nitrate

Cubosomes are nanoparticle, more accurately nano structure particles of a liquid crystalline phase with cubic crystallographic symmetry formed by the self-assembly of amphiphilic or surfactants like molecule. This study is to investigate the potential of cubosomes as lipid nanocarrier to improve the controlled release of Econazole Nitrate used for treatment of dermatophytes. Econazole Nitrate cubosomes were prepared by Top-down approach employing GMO as lipid phase vehicle, Poloxamer 407 as stabilizer and distilled water as aqueous phase. The resultant cubosomes dispersion were characterized by encapsulation efficiency, in-vitro drug release, particle size, zeta potential and FTIR. Best formulation (F4) showed a maximum drug release of 93.96 % in 8 hours, particle size of 230.1 nm and zeta potential of -19.1 mV. The best formulation was chosen on the basis of Optimization by Design of Expert software which will be incorporated into the carbopol 934 gel for the proper and feasible application of the formulation on skin.http://impactfactor.org/PDF/IJCPR/14/IJCPR,Vol14,Issue4,Article4.pd