Maternal MTHFR C677T Gen Mutasyonu Varlığının Yenidoğan Doğum Ağırlığı Üzerine Etkisi

Aim: reductase) gene mutation may diminish MTHFR activity and result in an increased homocystein level. It is thought that MTHFR gene mutation may cause intrauterine growth restriction. The aim of this study is to evaluate the effect of maternal MTHFR gene mutatıon presence on neonatal birth weights. Materials and Methods: The study population consists of MTHFR gene mutation group (n=71) and control group (n=36). Neonatal birth weights were compared between groups. Results: 107 pregnant women applying to Mustafa Kemal University Hospital were included in this study. Neonatal birth weights were lower in MTHFR gene mutatıon group than in control group. Conclusion: Our study result showed that neonatal birth weights were lower in MTHFR gene mutation group than in control group. Neonatal care may be necessary for newborn of mothers having MTHFR gene mutation. Further studies are needed to investigate the relation between MTHFR gene mutation and neonatal birth weight. Key reductase, Mutation words: methylenetetrahydrofolate weight, neonatal birth Gen