Development of 153Sm-DTPA-SPION as a theranostic dual contrast agents in SPECT/MRI

Objective(s): This study describes the preparation, biodistribution of 153Sm-DTPA-SPION after intravenous injection in rats. Materials and Methods: The chelator DTPA dianhydride was conjugated to SPION using a small modification of the well-known cyclic anhydride method. Conjugation was done at a 1: 4 (SPION: ccDTPA) molar ratio. Conjugation reaction was purified with magnetic assorting column (MACs) using high gradient magnetic field following incubation, the radio labeled conjugate was checked using RTLC method for labeling and purity checked. Results: The RTLC showed that labeling yield was above 99% after purification and the compound have good in vitro stabilities until 48 hr post injection in the presence of human serum. The biodistribution of 153Sm-DTPA-SPION in rats showed dramatic uptake in the reticuloendothelial system (RES) and their clearance is so fast in other organs especially in the blood. Biodistribution results show that after 30 min post injection more than 84% of injected activities were taken up by the liver and spleen (about 64% and 20%, respectively). Conclusion: Due to magnificent uptakes of this radiotracer in the liver and spleen and their fast clearance from other tissues, especially in blood, it is suggested that this radiotracer would be a potential candidate for RES theranostic purposes

Reasons for irregularities in classes at the beginning of each semester

Introduction: Irregularity or delay in the beginning of classes at each semester, due to absence of students and/or professors, is a common problem in most Iranian universities. This study aimed to investigate the reason for irregularities at the beginning of each semester according to the viewpoints of educational experts. Method: This cross-sectional study was carried out at three universities of medical sciences namely; Babol University of Medical Sciences, Shahid Beheshti University of Medical Sciences, and Iran University of Medical Sciences in the first academic semester of 2015-2016. This study investigated the viewpoints of educational experts working in four schools of medicine, dentistry, paramedicine, and public health using a researcher-made instrument. The instrument’s face validity was surveyed and confirmed by six faculty members and its reliability was tested by test-retest method (r=0.82). Descriptive statistics were used for data analysis. Results: According to a forty-two member panel of educational experts’ opinions, the main reasons for academic irregularities at the beginning of each semester is students’ absence followed by weak disciplinary rules, lack of implementation of regulations, teachers’ reluctance to hold classes on time, as well as not completing roll calls and not passing them to the registrar’s office. Conclusion: From the educational experts’ point of view, the factors related to students and teachers have greater effect on the recession of classes at the beginning of each academic semester. Therefore, a better planning for semesters and more control by authorities are required. &nbsp