Prioritization of Interconnected Processes

Deciding which business processes to improve is a challenge for all organizations. The literature on business process management (BPM) offers several approaches that support process prioritization. As many approaches share the individual process as unit of analysis, they determine the processes’ need for improvement mostly based on performance indicators, but neglect how processes are interconnected. So far, the interconnections of processes are only captured for descriptive purposes in process model repositories or business process architectures (BPAs). Prioritizing processes without catering for their interconnectedness, however, biases prioritization decisions and causes a misallocation of corporate funds. What is missing are process prioritization approaches that consider the processes’ individual need for improvement and their interconnectedness. To address this research problem, the authors propose the ProcessPageRank (PPR) as their main contribution. The PPR prioritizes processes of a given BPA by ranking them according to their network-adjusted need for improvement. The PPR builds on knowledge from process performance management, BPAs, and network analysis – particularly the Google PageRank. As for evaluation, the authors validated the PPR’s design specification against empirically validated and theory-backed design propositions. They also instantiated the PPR’s design specification as a software prototype and applied the prototype to a real-world BPA

ProcessPageRank - A Network-based Approach to Process Prioritization Decisions

Deciding which business processes to improve first is a challenge most corporate decision-makers face. The literature offers many approaches, techniques, and tools that support such process prioritization decisions. Despite the broad knowledge about measuring the performance of individual processes and determining related need for improvement, the interconnectedness of processes has not been considered in process prioritization decisions yet. So far, the interconnectedness of business processes is captured for descriptive purposes only, for example in business process architectures. This drawback systematically biases process prioritization decisions. As a first step to address this gap, we propose the ProcessPageRank (PPR), an algorithm based on the Google PageRank that ranks processes according to their network-adjusted need for improvement. The PPR is grounded in the literature related to process improvement, process performance measurement, and network analysis. For demonstration purposes, we created a software prototype and applied the PPR to five process network archetypes to illustrate how the interconnectedness of business processes affects process prioritization decisions

Unique Role of Caffeine Compared to Other Methylxanthines (Theobromine, Theophylline, Pentoxifylline, Propentofylline) in Regulation of AD Relevant Genes in Neuroblastoma SH-SY5Y Wild Type Cells

Methylxanthines are a group of substances derived from the purine base xanthine with a methyl group at the nitrogen on position 3 and different residues at the nitrogen on position 1 and 7. They are widely consumed in nutrition and used as pharmaceuticals. Here we investigate the transcriptional regulation of 83 genes linked to Alzheimer’s disease in the presence of five methylxanthines, including the most prominent naturally occurring methylxanthines—caffeine, theophylline and theobromine—and the synthetic methylxanthines pentoxifylline and propentofylline. Methylxanthine-regulated genes were found in pathways involved in processes including oxidative stress, lipid homeostasis, signal transduction, transcriptional regulation, as well as pathways involved in neuronal function. Interestingly, multivariate analysis revealed different or inverse effects on gene regulation for caffeine compared to the other methylxanthines, which was further substantiated by multiple comparison analysis, pointing out a distinct role for caffeine in gene regulation. Our results not only underline the beneficial effects of methylxanthines in the regulation of genes in neuroblastoma wild-type cells linked to neurodegenerative diseases in general, but also demonstrate that individual methylxanthines like caffeine mediate unique or inverse expression patterns. This suggests that the replacement of single methylxanthines by others could result in unexpected effects, which could not be anticipated by the comparison to other substances in this substance class

Characteristics of Patients Lost to Follow-up after Bariatric Surgery

After bariatric surgery lifelong follow-up is recommended. Evidence of the consequences and reasons for being lost to follow-up (LTFU) is sparse. In this prospective study follow-up data of all patients who underwent bariatric surgery between 2008 and 2017 at a certified obesity centre were investigated. LTFU patients were evaluated through a structured telephone interview. Overall, 573 patients (female/male 70.9%/29.1%), aged 44.1 ± 11.2 years, preoperative BMI 52.1 ± 8.4 kg/m2 underwent bariatric surgery. Out of these, 33.2% had type 2 diabetes mellitus and 74.4% had arterial hypertension. A total of 290 patients were LTFU, of those 82.1% could be reached. Baseline characteristics of patients in follow-up (IFU) and LTFU were comparable, but men were more often LTFU (p = 0.01). Reported postoperative total weight loss (%TWL) and improvements of comorbidities were comparable, but %TWL was higher in patients remaining in follow-up for at least 2 years (p = 0.013). Travel issues were mentioned as the main reason for being LTFU. A percentage of 77.6% of patients reported to regularly supplement micronutrients, while 71.0% stated regular monitoring of their micronutrient status, mostly by primary care physicians. Despite comparable reported outcomes of LTFU to IFU patients, the duration of the in-centre follow-up period affected %TWL. There is a lack of sufficient supplementation and monitoring of micronutrients in a considerable number of LTFU patients

The Darmstadt Energy Laboratory for Technologies in Application: Overview Paper – Living Lab DELTA

In the living lab DELTA, energy system methods are applied, and energy technology systems are installed to transfer successful pilot projects of the urban energy transition to a broad application. The focus is on the consistent improvement of energy efficiency in all sectors, which is already considered to be the largest usable potential of the urban energy transition. In addition, the potential for shifting electrical loads over time to optimize the integration of renewable energy sources will be identified. Energy efficiency and flexibility will be achieved by intelligently linking individual districts of the urban energy system and by sector coupling. The development of a holistic innovation ecosystem is essential to enable all stakeholders in the energy system to participate in the energy and economic potential. To this end, the project pursues a multi-level, cross-sectoral approach

Das Darmstädter Energie-Labor für Technologien in der Anwendung: Übersichtspapier - Reallabor DELTA

Im Reallabor DELTA werden energiesystemische Methoden angewendet und energietechnische Anlagen errichtet, um erfolgreiche Pilotprojekte der urbanen Energiewende in die breite Anwendung zu überführen. Im Mittelpunkt steht die konsequente Steigerung der Energieeffizienz in allen Sektoren, die bereits heute als größtes nutzbares Potenzial der urbanen Energiewende gilt. Darüber hinaus sollen Potenziale zur zeitlichen Verschiebung elektrischer Lasten identifiziert und zur optimalen Einbindung erneuerbarer Energiequellen genutzt werden. Energieeffizienz und -flexibilität werden durch die intelligente Verknüpfung einzelner Quartiere des betrachteten städtischen Energiesystems sowie durch Sektorkopplung erreicht. Wesentlich ist dabei die Entwicklung eines ganzheitlichen Innovationsökosystems, um alle Akteur:innen des Energiesystems an den energetischen und wirtschaftlichen Potenzialen teilhaben zu lassen. Hierzu wird im Projekt ein mehrstufiger, sektorübergreifender Ansatz verfolgt

IL7R is associated with CNS infiltration and relapse in pediatric B-cell precursor acute lymphoblastic leukemia

No abstract available

Subsurface hydrothermal processes and the bioenergetics of chemolithoautotrophy at the shallow-sea vents off Panarea Island (Italy)

The subsurface evolution of shallow-sea hydrothermal fluids is a function of many factors including fluid-mineral equilibria, phase separation, magmatic inputs, and mineral precipitation, all of which influence discharging fluid chemistry and consequently associated seafloor microbial communities. Shallow-sea vent systems, however, are understudied in this regard. In order to investigate subsurface processes in a shallow-sea hydrothermal vent, and determine how these physical and chemical parameters influence the metabolic potential of the microbial communities, three shallow-sea hydrothermal vents associated with Panarea Island (Italy) were characterized. Vent fluids, pore fluids and gases at the three sites were sampled and analyzed for major and minor elements, redox-sensitive compounds, free gas compositions, and strontium isotopes. The corresponding data were used to 1) describe the subsurface geochemical evolution of the fluids and 2) to evaluate the catabolic potential of 61 inorganic redox reactions for in situ microbial communities. Generally, the vent fluids can be hot (up to 135 °C), acidic (pH 1.9-5.7), and sulfidic (up to 2.5 mM H2S). Three distinct types of hydrothermal fluids were identified, each with higher temperatures and lower pH, Mg2 + and SO42 -, relative to seawater. Type 1 was consistently more saline than Type 2, and both were more saline than seawater. Type 3 fluids were similar to or slightly depleted in most major ions relative to seawater. End-member calculations of conservative elements indicate that Type 1 and Type 2 fluids are derived from two different sources, most likely 1) a deeper, higher salinity reservoir and 2) a shallower, lower salinity reservoir, respectively, in a layered hydrothermal system. The deeper reservoir records some of the highest end-member Cl concentrations to date, and developed as a result of recirculation of brine fluids with long term loss of steam and volatiles due to past phase separation. No strong evidence for ongoing phase separation is observed. Type 3 fluids are suggested to be mostly influenced by degassing of volatiles and subsequently dissolution of CO2, H2S, and other gases into the aqueous phase. Gibbs energies (ΔGr) of redox reactions that couple potential terminal electron acceptors (O2, NO3-, MnIV, FeIII, SO42 -, S0, CO2,) with potential electron donors (H2, NH4+, Fe2 +, Mn2 +, H2S, CH4) were evaluated at in situ temperatures and compositions for each site and by fluid type. When Gibbs energies of reaction are normalized per kilogram of hydrothermal fluid, sulfur oxidation reactions are the most exergonic, while the oxidation of Fe2 +, NH4+, CH4, and Mn2 + are moderately energy yielding. The energetics calculations indicate that the most robust microbial communities in the Panarea hot springs combine H2S from deep water-rock-gas interactions with O2 that is entrained via seawater mixing to fuel their activities, regardless of site location or fluid type

Interactions among mitochondrial proteins altered in glioblastoma

Mitochondrial dysfunction is putatively central to glioblastoma (GBM) pathophysiology but there has been no systematic analysis in GBM of the proteins which are integral to mitochondrial function. Alterations in proteins in mitochondrial enriched fractions from patients with GBM were defined with label-free liquid chromatography mass spectrometry. 256 mitochondrially-associated proteins were identified in mitochondrial enriched fractions and 117 of these mitochondrial proteins were markedly (fold-change ≥2) and significantly altered in GBM (p ≤ 0.05). Proteins associated with oxidative damage (including catalase, superoxide dismutase 2, peroxiredoxin 1 and peroxiredoxin 4) were increased in GBM. Protein–protein interaction analysis highlighted a reduction in multiple proteins coupled to energy metabolism (in particular respiratory chain proteins, including 23 complex-I proteins). Qualitative ultrastructural analysis in GBM with electron microscopy showed a notably higher prevalence of mitochondria with cristolysis in GBM. This study highlights the complex mitochondrial proteomic adjustments which occur in GBM pathophysiology