Caractéristiques des ajustements de prix en France et dans la zone euro : quelques faits stylisés tirés des données individuelles de prix à la consommation.

fréquence de changement de prix, prix à la consommation, rigidité des prix.

Centuries of intense surface melt on Larsen C Ice Shelf

Following a southward progression of ice-shelf disintegration along the Antarctic Peninsula, Larsen C Ice Shelf is the focus of ongoing investigation regarding its future stability. The ice shelf is known to be experience surface melt, and commonly features surface meltwater ponds. Here, we use a flowline model and a firn density model to date and interpret observations of melt-affected ice layers found within five 90?m boreholes distributed across the ice shelf. We find that units of ice within the boreholes, which have densities exceeding those expected under normal compaction metamorphism, correspond to two climatic warm periods within the last 300 years on the Antarctic Peninsula. The more recent warm period, from the 1960s onwards, has generated distinct sections of dense ice in two boreholes in Cabinet Inlet, close to the Antarctic Peninsula mountains ? a region currently affected by f?hn winds. Previous work has classified these layers as refrozen pond ice, requiring large quantities of mobile liquid water to form. Our flowline model shows that, whilst preconditioning of the ice began in the late 1960s, it was probably not until the early 1990s that twentieth-century ponding began. The earlier warm period occurred during the 18th century and resulted in two additional sections of anomalously dense ice deep within the boreholes. The first, in one of the Cabinet Inlet boreholes, consists of ice characteristic of refrozen ponds and must have formed in an area currently featuring ponding. The second, in a mid-shelf borehole, formed at the same time in an area which now experiences significant annual melt. Further south on the shelf, the boreholes sample ice that is of an equivalent age but which does not exhibit the same degree of melt influence. This west?east and north?south gradient in past melt distribution resembles current spatial patterns of surface melt intensity. Using flowlines to trace the advection and submergence of continental ice identified in boreholes, we demonstrate that, even by the time the ice reaches the calving front, only the upper 40 to 50?% of the shelf is composed of meteoric ice accumulated on the shelf. This vertical composition implies that basal crevasses must be confined within continental and/or basally accreted ice, and therefore will be unaffected by current climate-induced firn compactionauthorsversio

Ice and firn heterogeneity within Larsen C Ice Shelf from borehole optical televiewing

Research was funded by the UK Natural Environmental Research Council grants NE/L006707/1 and NE/L005409/1 and a HEFCW/Aberystwyth University Capital Equipment Grant to B.H. Data will be available via the project website (www.projectmidas.org) and the UK Polar Data Centre (https://www.bas.ac.uk/data/uk-pdc/) from mid-2017.We use borehole optical televiewing (OPTV) to explore the internal structure of Larsen C Ice Shelf (LCIS). We report a suite of five ~90 m long OPTV logs, recording a light-emitting diode-illuminated, geometrically correct image of the borehole wall, from the northern and central sectors of LCIS collected during austral spring 2014 and 2015. We use a thresholding-based technique to estimate the refrozen ice content of the ice column and exploit a recently calibrated density-luminosity relationship to reveal its structure. All sites are dense and strongly influenced by surface melt, with frequent refrozen ice layers and mean densities, between the depths of 1.87 and 90 m, ranging from 862 to 894 kg m−3. We define four distinct units that comprise LCIS and relate these to ice provenance, dynamic history, and past melt events. These units are in situ meteoric ice with infiltration ice (U1), meteoric ice which has undergone enhanced densification (U2), thick refrozen ice (U3), and advected continental ice (U4). We show that the OPTV-derived pattern of firn air content is consistent with previous estimates, but that a significant proportion of firn air is contained within U4, which we interpret to have been deposited inland of the grounding line. The structure of LCIS is strongly influenced by the E-W gradient in föhn-driven melting, with sites close to the Antarctic Peninsula being predominantly composed of refrozen ice. Melting is also substantial toward the ice shelf center with >40% of the overall imaged ice column being composed of refrozen ice.Publisher PDFPeer reviewe

Massive subsurface ice formed by refreezing of ice-shelf melt ponds

Surface melt ponds form intermittently on several Antarctic ice shelves. Although implicated in ice-shelf break up, the consequences of such ponding for ice formation and ice-shelf structure have not been evaluated. Here we report the discovery of a massive subsurface ice layer, at least 16 km across, several kilometres long and tens of metres deep, located in an area of intense melting and intermittent ponding on Larsen C Ice Shelf, Antarctica. We combine borehole optical televiewer logging and radar measurements with remote sensing and firn modelling to investigate the layer, found to be ∼10 C warmer and ∼170 kg m¯³ denser than anticipated in the absence of ponding and hitherto used in models of ice-shelf fracture and flow. Surface ponding and ice layers such as the one we report are likely to form on a wider range of Antarctic ice shelves in response to climatic warming in forthcoming decades

Estrogen regulation of TRPM8 expression in breast cancer cells

<p>Abstract</p> <p>Background</p> <p>The calcium-permeable cation channel TRPM8 (melastatin-related transient receptor potential member 8) is over-expressed in several cancers. The present study aimed at investigating the expression, function and potential regulation of TRPM8 channels by ER alpha (estrogen receptor alpha) in breast cancer.</p> <p>Methods</p> <p>RT-PCR, Western blot, immuno-histochemical, and siRNA techniques were used to investigate TRPM8 expression, its regulation by estrogen receptors, and its expression in breast tissue. To investigate the channel activity in MCF-7 cells, we used the whole cell patch clamp and the calcium imaging techniques.</p> <p>Results</p> <p>TRPM8 channels are expressed at both mRNA and protein levels in the breast cancer cell line MCF-7. Bath application of the potent TRPM8 agonist Icilin (20 μM) induced a strong outwardly rectifying current at depolarizing potentials, which is associated with an elevation of cytosolic calcium concentration, consistent with established TRPM8 channel properties. RT-PCR experiments revealed a decrease in TRPM8 mRNA expression following steroid deprivation for 48 and 72 hours. In steroid deprived medium, addition of 17-beta-estradiol (E₂, 10 nM) increased both TRPM8 mRNA expression and the number of cells which respond to Icilin, but failed to affect the Ca²⁺entry amplitude. Moreover, silencing ERα mRNA expression with small interfering RNA reduced the expression of TRPM8. Immuno-histochemical examination of the expression of TRPM8 channels in human breast tissues revealed an over-expression of TRPM8 in breast adenocarcinomas, which is correlated with estrogen receptor positive (ER⁺) status of the tumours.</p> <p>Conclusion</p> <p>Taken together, these results show that TRPM8 channels are expressed and functional in breast cancer and that their expression is regulated by ER alpha.</p

Expression of TRPC6 channels in human epithelial breast cancer cells

<p>Abstract</p> <p>Background</p> <p>TRP channels have been shown to be involved in tumour generation and malignant growth. However, the expression of these channels in breast cancer remains unclear. Here we studied the expression and function of endogenous TRPC6 channels in a breast cancer cell line (MCF-7), a human breast cancer epithelial primary culture (hBCE) and in normal and tumour breast tissues.</p> <p>Methods</p> <p>Molecular (Western blot and RT-PCR), and immunohistochemical techniques were used to investigate TRPC6 expression. To investigate the channel activity in both MCF-7 cells and hBCE we used electrophysiological technique (whole cell patch clamp configuration).</p> <p>Results</p> <p>A non selective cationic current was activated by the oleoyl-2-acetyl-sn-glycerol (OAG) in both hBCE and MCF-7 cells. OAG-inward current was inhibited by 2-APB, SK&F 96365 and La³⁺. TRPC6, but not TRPC7, was expressed both in hBCE and in MCF-7 cells. TRPC3 was only expressed in hBCE. Clinically, TRPC6 mRNA and protein were elevated in breast carcinoma specimens in comparison to normal breast tissue. Furthermore, we found that the overexpression of TRPC6 protein levels were not correlated with tumour grades, estrogen receptor expression or lymph node positive tumours.</p> <p>Conclusion</p> <p>Our results indicate that TRPC6 channels are strongly expressed and functional in breast cancer epithelial cells. Moreover, the overexpression of these channels appears without any correlation with tumour grade, ER expression and lymph node metastasis. Our findings support the idea that TRPC6 may have a role in breast carcinogenesis.</p

Twenty-first century glacier slowdown driven by mass loss in High Mountain Asia

International audienc

Break in the Mean and Persistence of Inflation: A Sectoral Analysis of French CPI

This paper uses disaggregated CPI time series to show that a break in the mean of French inflation occurred in the mid-eighties and that the 1983 monetary policy shift mostly accounted for it. CPI average yearly growth declined from nearly 11% before the break date (May 1985) to 2.1% after. No other break in the 1973-2004 sample period can be found. Controlling for this mean break, both aggregate and sectoral inflation persistence are stable and low, with the unit root lying far in the tail of the persistence estimates. However, persistence differs dramatically across sectors. Finally, the duration between two price changes (at the firm level) appears positively related with inflation persistence (at the aggregate level)

The management of acute venous thromboembolism in clinical practice. Results from the European PREFER in VTE Registry

Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in Europe. Data from real-world registries are necessary, as clinical trials do not represent the full spectrum of VTE patients seen in clinical practice. We aimed to document the epidemiology, management and outcomes of VTE using data from a large, observational database. PREFER in VTE was an international, non-interventional disease registry conducted between January 2013 and July 2015 in primary and secondary care across seven European countries. Consecutive patients with acute VTE were documented and followed up over 12 months. PREFER in VTE included 3,455 patients with a mean age of 60.8 ± 17.0 years. Overall, 53.0 % were male. The majority of patients were assessed in the hospital setting as inpatients or outpatients (78.5 %). The diagnosis was deep-vein thrombosis (DVT) in 59.5 % and pulmonary embolism (PE) in 40.5 %. The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5 %), hypertension (42.3 %) and dyslipidaemia (21.1 %). Following the index VTE, a large proportion of patients received initial therapy with heparin (73.2 %), almost half received a vitamin K antagonist (48.7 %) and nearly a quarter received a DOAC (24.5 %). Almost a quarter of all presentations were for recurrent VTE, with &gt;80 % of previous episodes having occurred more than 12 months prior to baseline. In conclusion, PREFER in VTE has provided contemporary insights into VTE patients and their real-world management, including their baseline characteristics, risk factors, disease history, symptoms and signs, initial therapy and outcomes