9 research outputs found
Advancing biological understanding and therapeutics discovery with small-molecule probes
- Author
- Alexander B.R.
- Ananthan S.
- Aubé J.
- Austin C.P.
- Bittker J.A.
- Chung D.-H.
- Chung T.D.Y.
- Clemons P.A.
- Conn P.J.
- Cravatt B.F.
- De Souza A.
- Edwards B.
- Emmitte K.A.
- Foley M.A.
- Golden J.E.
- Griffin P.R.
- Hodder P.S.
- Hopkins C.R.
- Jackson M.R.
- Jadhav A.
- Jonsson C.B.
- Kotz J.D.
- Li M.
- Lindsley C.W.
- McManus O.
- Noah J.W.
- Oprea T.I.
- Palmer M.
- Pinkerton A.B.
- Reed J.C.
- Roberts E.
- Rosen H.
- Roush W.R.
- Schoenen F.J.
- Schreiber S.L.
- Severson W.E.
- Shamji A.F.
- Simeonov A.
- Sklar L.A.
- Stauffer S.R.
- Wawer M.J.
- White E.L.
- Wood M.R.
- Wu M.
- Yu H.
- Zou B.
- Publication venue
- Cell Press
- Publication date
- 01/01/2015
- Field of study
Small-molecule probes can illuminate biological processes and aid in the assessment of emerging therapeutic targets by perturbing biological systems in a manner distinct from other experimental approaches. Despite the tremendous promise of chemical tools for investigating biology and disease, small-molecule probes were unavailable for most targets and pathways as recently as a decade ago. In 2005, the NIH launched the decade-long Molecular Libraries Program with the intent of innovating in and broadening access to small-molecule science. This Perspective describes how novel small-molecule probes identified through the program are enabling the exploration of biological pathways and therapeutic hypotheses not otherwise testable. These experiences illustrate how small-molecule probes can help bridge the chasm between biological research and the development of medicines but also highlight the need to innovate the science of therapeutic discovery
Sex determination in honey bees (Apinae and Meliponinae) and its consequences
- Author
- Adams J.
- Beig D.
- Beukeboom L.W.
- Bonetti A.M
- Bonetti A.M.
- Borstel R.C. Von
- Brenha S.L.A.
- Bridges C.B.
- Camargo C.A.
- Camargo C.A.
- Camargo C.A.
- Camargo C.A.
- Cameron S.A.
- Campos L.A.
- Campos L.A.O.
- Campos L.A.O.
- Campos L.A.O.
- Carvalho G.A.
- Chaud-Neto J.
- Chaud-Neto J.
- Chaud-Neto J.
- Chaud-Neto J.
- Cook J.M.
- Cortopasi-Laurino M.
- Crozier R.H.
- Cruz-Landim C.
- Cunha A.B.
- Devlin R.H.
- Dobzhansky T.
- Drory E.
- Drory E.
- Drory E.
- Drummond M.S.
- Dzierzon J.
- Dzierzon J.
- Dzierzon J.
- Dzierzon J.
- Engels E.
- Garofalo C.
- Garofalo C.A.
- Gergen J.P.
- Goldschmidt R.B.
- Gondim C.G.E.
- Hartfelder K.
- Hoshiba H.
- Imai H.T.
- Imperatriz-Fonseca V.L.
- Imperatriz-Fonseca V.L.
- Kelley R.L.
- Kerr W.E.
- Kerr W.E.
- Kerr W.E.
- Kerr W.E.
- Kerr W.E.
- Kerr W.E.
- Kerr W.E.
- Kerr W.E.
- Kerr W.E.
- Kerr W.E.
- Kerr W.E.
- Kerr W.E.
- Kerr W.E.
- Kerr W.E.
- Kerr W.E.
- Kerr W.E.
- Kerr W.E.
- Kerr W.E.
- Kerr W.E.
- Kerr W.E.
- Kerr W.E.
- Laidlaw H.H.
- Legner E.F.
- Maciel-Silva V.
- Mackensen O.
- Mackensen O.
- Makino S.
- Manning F.J.
- Meves F.
- Mitchell T.B.
- Mitchell T.B.
- Mota M.H.V.B.
- Nachtsheim H.
- Nogueira -Neto P.
- Nogueira-Neto P.
- Oliveira D.A.G.
- Oliveira D.A.G.
- Parkhurst S.M.
- Paulcke W.
- Petrunkewitsch A.
- Quintero D.A
- Riek E.F.
- Rothenbuler W.
- Rothenbuler W.C.
- Salt G.H.
- Schmidt G.H.
- Severson D.W.
- Siebold C.TH.
- Siebold C.TH.
- Silva D.L.N.
- Tucker K.W.
- Velthuis H.H.W.
- Von Frisch K.
- Warwick Estevam Kerr
- Whiting P.W.
- Whiting P.W.
- Wilson F.
- Woyke J.
- Woyke J.
- Woyke J.
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
The Effect of 50 kV X-ray Irradiation on the Alkaline Phosphatase Activity of Growing Rat Bone
- Author
- Alcock N.W
- Bernard G.W
- Blackburn J.
- Borle A.B.
- Cohn S.G.
- Colton F
- Engström H.
- Furstman L.L
- Granström G.
- Kember N.F.
- Lowry O.H.
- Sams A
- Severson A.R.
- The Committee on Enzymes of the Scandinavian Society for Clinical Chemistry and Clinical Physiology
- Wawrzkiewics M
- Wergedal J.E
- Wergedal J.E.
- Wilkins W.E.
- Woodard H.Q.
- Woodard H.Q.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Mitogenic and Nutritional Signals Are Transduced into Translational Efficiency of TOP mRNAs
- Author
- Agrawal A.G.
- Aloni R.
- Amaldi F.
- Avni D.
- Chung J.
- Erikson E.
- Fox H.L.
- Gressner A.M.
- Grummt I.
- Jefferies H.B.J.
- Jefferies H.B.J.
- Kaspar R.L.
- Kozma S.C.
- Krieg J.
- Levy S.
- Loreni F.
- Meyuhas O.
- Nygard O.
- Patti M.E.
- Price D.J.
- Rabkin R.
- Rao T.R.
- Severson W.E.
- Slobin L.I.
- Sturgill T.W.
- Terada N.
- Thomas G.
- Thomas G.
- von Manteuffel S.
- Wang X.
- Publication venue
- 'Cold Spring Harbor Laboratory'
- Publication date
- Field of study
Foot-and-Mouth Disease Virus Evolution: Exploring Pathways Towards Virus Extinction
- Author
- A. Airaksinen
- A. Arias
- A. Grande-PĂ©rez
- A. Ishihama
- A.M. Contreras
- B. Mangeat
- C. EscarmĂs
- C. EscarmĂs
- C. EscarmĂs
- C.H. Lee
- C.M. Ruiz-Jarabo
- C.M. RuĂz-Jarabo
- C.M. RuĂz-Jarabo
- D. Alves
- D. Lecossier
- D. Maag
- E Domingo
- E. Baranowski
- E. Baranowski
- E. Domingo
- E. Domingo
- E. Domingo
- E. Domingo
- E. Domingo
- E. Duarte
- E. Lázaro
- E. Lázaro
- E. Yuste
- E.A. Duarte
- F. Bushman
- H. Zhang
- H.J. Muller
- H.L. Bachrach
- I.S. Novella
- I.S. Novella
- I.S. Novella
- J. Araki
- J. Arnold
- J. Holland
- J. Maynard-Smith
- J. Swetina
- J.A. Kinsey
- J.C. Torre de la
- J.D. Graci
- J.I. Núñez
- J.J. Holland
- J.T. Kimata
- J.W. Drake
- L. Chao
- L. Menéndez-Arias
- L. Menéndez-Arias
- L.A. Loeb
- L.A. Loeb
- L.S. Ripley
- M. Eigen
- M. Eigen
- M. Eigen
- M. Eigen
- M. Eigen
- M. Gell-Mann
- M. Nilsson
- M. Nowak
- M.G. Mateu
- M.S. Rose
- N. Pariente
- N.J. Snell
- P. Sutmoller
- P.W. Mason
- R. Acharya
- R.E. Lanford
- R.S. Harris
- S. Crotty
- S. Crotty
- S. Sierra
- S. Zhou
- S.C. Manrubia
- T. Jackson
- T.R. Doel
- W.E. Severson
- W.J. Weibull
- Y. Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2005
- Field of study
Population Bottlenecks in Quasispecies Dynamics
- Author
- A. Colato
- A. Grande-PĂ©rez
- A.S. Kondrashov
- A.S. Kondrashov
- C. EscarmĂs
- C. EscarmĂs
- C. EscarmĂs
- C. Zeyl
- C.L. Burch
- C.O. Wilke
- C.O. Wilke
- C.O. Wilke
- C.T. Bergstrom
- C.T. Bergstrom
- D. Bachtrog
- D. Charlesworth
- D. Clarke
- D.I. Andersson
- D.J. Earl
- D.S. Wilson
- E. Batschelet
- E. Duarte
- E. Lázaro
- E. Lázaro
- E. Yuste
- E. Yuste
- E. Yuste
- E.A. Duarte
- F.J. Ayala
- G. Bell
- G. Bell
- G.P. Wagner
- H. Harpending
- H.A. Orr
- H.J. Muller
- I. Gordo
- I.M. Rouzine
- I.S. Novella
- I.S. Novella
- I.S. Novella
- I.S. Novella
- I.S. Novella
- J. Felsenstein
- J. Haigh
- J. Maynard Smith
- J. Quer
- J. Quer
- J. Swetina
- J.B.S. Haldane
- J.B.S. Haldane
- J.D. Fry
- J.F. Crow
- J.J. Bull
- J.R. Peck
- J.W. Drake
- L. Chao
- L. Chao
- L.L. Vassilieva
- M. Artenstein
- M. Eigen
- M. Eigen
- M. Eigen
- M. Kimura
- M. Lynch
- M. Peña De la
- M.A. Huynen
- M.A. Nowak
- N. Pariente
- P. Funchain
- P.J. Gerone
- P.W. Ewald
- P.W. Mason
- R. Froissart
- R. Sanjuán
- R.A. Fisher
- R.A. Fisher
- S. Crotty
- S. Lea
- S. Maisnier-Patin
- S. Pang
- S. Sierra
- S. Wright
- S. Wright
- S.C. Manrubia
- S.C. Manrubia
- S.C. Weaver
- S.F. Elena
- S.F. Elena
- S.F. Elena
- S.F. Elena
- T. Hovi
- T.T. Kibota
- V. Wittke
- W. Stephan
- W.E. Severson
- X.-S. Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2006
- Field of study
Viruses as Quasispecies: Biological Implications
- Author
- A. Airaksinen
- A. Arias
- A. Arias
- A. Grande-PĂ©rez
- A. Grande-PĂ©rez
- A. Grande-PĂ©rez
- A.C. Karlsson
- A.M. Contreras
- A.S. Huang
- B. Borrego
- C. Briones
- C. Briones
- C. Charpentier
- C. Condit
- C. EscarmĂs
- C. González-López
- C. González-López
- C. Perales
- C. Welsh
- C.A. Wyatt
- C.H. Lee
- C.K. Biebricher
- C.M. Ruiz-Jarabo
- C.M. Ruiz-Jarabo
- C.M. Ruiz-Jarabo
- C.M. Ruiz-Jarabo
- C.O. Wilke
- C.R. Pringle
- C.R. Woese
- C.T. Bergstrom
- C.T. Cornell
- D. Maag
- D.O. White
- D.T. Lau
- D.W. Mount
- DJ Rowlands
- E. Baranowski
- E. Domingo
- E. Domingo
- E. Domingo
- E. Domingo
- E. Domingo
- E. Domingo
- E. Domingo
- E. Domingo
- E. Domingo
- E. Domingo
- E. Domingo
- E.J. Snijder
- G.C. Williams
- G.H. Kijak
- H. Imamichi
- I. Nájera
- I.M. Moreno
- I.S. Novella
- I.S. Novella
- I.S. Novella
- I.S. Novella
- I.S. Novella
- J. GarcĂa-Arriaza
- J. GarcĂa-Arriaza
- J. Perrault
- J. Swetina
- J.C. Torre De la
- J.D. Graci
- J.G. GarcĂa-Lerma
- J.G. McHutchison
- J.J. Holland
- J.J. Holland
- J.J. Holland
- J.M. Coffin
- J.P. Anderson
- J.S. Youngner
- J.W. Drake
- K.M. Chumakov
- L.A. Loeb
- L.A. Loeb
- M. Eigen
- M. Eigen
- M. Eigen
- M. Eigen
- M. Eigen
- M. Gell-Mann
- M. Nowak
- M.A. Nowak
- M.B.A. Oldstone
- M.E. Quiñones-Mateu
- M.E.J. Woolhouse
- M.N. Teng
- M.S. Freistadt
- M.V. Volkenstein
- N. Pariente
- N.J. Snell
- N.V. Vo
- P. Borrow
- P. Simmonds
- P. Simmonds
- P.E. Turner
- P.J. Gerrish
- P.S. Eastman
- R. Miralles
- R. Solé
- R.C. Lewontin
- R.E. Lanford
- R.M. Ribeiro
- S. Crotty
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- S. Sierra
- S.A. Frank
- S.J. Flint
- T. Dobzhansky
- V.I. Agol
- V.R. DeFilippis
- W.B. Parker
- W.E. Severson
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2006
- Field of study
Transitions in Understanding of RNA Viruses: A Historical Perspective
- Author
- A. Airaksinen
- A. Arias
- A. Flamand
- A. Gierer
- A. Granoff
- A. Granoff
- A. Kawai
- A. Portner
- A.B. Sabin
- A.D. Hershey
- A.M. King
- B. Dietzschold
- B.A. Brown
- B.K. Notay
- B.K. Rima
- B.N. Fields
- B.N. Fields
- C. Briones
- C. Escarmis
- C. Escarmis
- C. Escarmis
- C. González-López
- C. Schmaljohn
- C.D. Ward
- C.G. Cupples
- C.H. Lee
- C.K. Biebricher
- C.K. Biebricher
- C.K. Biebricher
- C.K. Biebricher
- C.M. Ruiz-Jarabo
- C.M. Ruiz-Jarabo
- C.M. Ruiz-Jarabo
- C.R. Pringle
- C.R. Pringle
- C.R. Pringle
- D. Baltimore
- D. Iwanowski
- D. Maag
- D. Zimmern
- D.A. Steinhauer
- D.A. Steinhauer
- D.A. Steinhauer
- D.A. Steinhauer
- D.B. Smith
- D.C. Reanney
- D.K. Clarke
- D.K. Clarke
- D.R. Mills
- E. Batschelet
- E. Domingo
- E. Domingo
- E. Domingo
- E. Domingo
- E. Domingo
- E. Domingo
- E. Domingo
- E. Domingo
- E. Domingo
- E. Domingo
- E. Lazaro
- E. Lazaro
- E. Wimmer
- E.A. Duarte
- E.A. Duarte
- E.A. Duarte
- E.F. Zimmerman
- E.J. Rhozon
- F. D’Herelle
- F. Gebauer
- F. Loeffler
- F. Sobrino
- F.M. Burnet
- G. Appleyard
- G.F. Gause
- G.K. Hirst
- G.M. Findlay
- G.P. Berry
- H. Frankel-Conrat
- H. Frankel-Conrat
- H.J. Eggers
- H.J. Muller
- I. Haruna
- I.S. Novella
- I.S. Novella
- I.S. Novella
- I.S. Novella
- J. Enders
- J. Meinkoth
- J. Quer
- J. Quer
- J. Swetina
- J.A. Mudd
- J.B. Buist
- J.C. Torre De la
- J.C. Torre De la
- J.D. Watson
- J.F. Enders
- J.H. Strauss
- J.H. Strauss
- J.J. Holland
- J.J. Holland
- J.J. Holland
- J.J. Holland
- J.J. Holland
- J.J. Holland
- J.J. Holland
- J.J. Holland
- J.J. Holland
- J.J. Holland
- J.M. Coffin
- J.M. Ramseur
- J.S. Youngner
- J.W. Drake
- J.W. Drake
- J.W. Drake
- J.W. Drake
- K. Horiuchi
- K.W. Mundry
- L. Chao
- L. Pasteur
- L. Roux
- L. Roux
- L. Valen Van
- L.A. Loeb
- L.O. Kunkle
- M. Eigen
- M. Eigen
- M. Eigen
- M. Eigen
- M. Eigen
- M. Eigen
- M. Popescu
- M. Theiler
- M.W. Beijerinck
- N. Ledinko
- N. Nathanson
- N. Rohde
- N. Takeda
- N.P. Salzman
- O.M. Kew
- O.M. Kew
- O.T. Avery
- O.T. Preble
- P. Palese
- P. Schuster
- P.D. Cooper
- R. Ahmed
- R. Dulbecco
- R.C. Valentine
- R.E. Shope
- R.G. Webster
- R.G. Webster
- R.G. Webster
- R.H. Doi
- R.I. Carp
- R.M. Franklin
- R.R. Wagner
- S. Crotty
- S. Crotty
- S. Halle
- S. Spiegelman
- S.C. Weaver
- S.E. Luria
- S.E. Pincus
- S.J. Schrag
- S.T. Nichol
- T.E. Rawlins
- V. Meulen Ter
- V.K. Pathak
- W.E. Severson
- W.J. Elford
- W.J. Elford
- W.M. Stanley
- Y. Nishiyama
- Y. Nishiyama
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2006
- Field of study
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