Two year follow-up of clinical and inflammation parameters in children monosensitized to mites undergoing subcutaneous and sublingual immunotherapy

PubMedID: 24053706Background: Both SCIT (subcutaneous immunotherapy) and SLIT (sublingual immunotherapy) have clinical and immunologic efficacy in children with rhinitis and asthma but comparative studies are scarce. Objective: To investigate the clinical and immunological efficacy of mite-specific SLIT and SCIT in children with rhinitis and asthma. Method: Thirty children monosensitized to house dust mite were randomized to receive either active SCIT or SLIT or placebo for 1 yr in a double-blind double-dummy placebo controlled design (Yukselen A et al., Int Arch Allergy Immunol 2012; 157:288-298). Thereafter, the placebo group was randomized to receive SCIT or SLIT, and for 1 yr all patients received active treatment with SCIT or SLIT. Symptom scores, drug usage, titrated skin prick tests, nasal and bronchial allergen provocation doses, serum house dust mite-specific immunglobulin E, sIgG4, IL-10 and IFN- ? levels were evaluated. Results: The reduction of clinical scores with SLIT was more evident after 2 years of treatment in comparison to both the baseline and DBPC phase of the study. The change in titrated skin prick tests and nasal provocative doses was more prominent with both SCIT and SLIT at the end of the open phase. Although the increase in bronchial provocative doses was not significant at the end of the first year of treatment with SLIT, it reached a statistically significant difference after two years of treatment. Conclusion: The clinical efficacy of SLIT is more prominent at the end of the second year, although this improvement is observed from the first year of treatment with SCIT in mite-sensitive children

Eczema prevalence and affecting risk factors in the Adana and Payas (Hatay)

Bu çalışmada, egzema prevalansını ve etkileyen risk faktörlerini araştırmayı amaçladık. Çalışma, 6-18 yaş arasındaki okul çağı çocukları rasgele seçilerek yapıldı. Soru listesi, International Study of Asthma and Allergies In Childhood (ISAAC) soru listesi temel alınarak oluşturuldu. Adana'da 3164 (% 51.9 kız, % 48.1 erkek), Payas'ta 1353 (% 50.5 kız, % 49.5 erkek) öğrenci çalışmaya dahil edildi. Egzema prevalansı; Adana'da % 8.3, Payasta ise % 9.3 olarak saptandı. Bu iki yerleşim birimindeki fark istatistiksel olarak anlamlı değildi (p=0.27). Ailesel atopi, allerjik rinit ve astımın öğrencide bulunması, Adana ve Payas'taki çocuklarda egzema için risk oluşturmaktaydı (P0.05). Payas'taki çocuklar için ise annenin sigara içmesi, çocukların tüylü oyuncağının olması egzema için risk oluştururken (p0.05).The aim of this study was to determine the prevalence of eczema and factors affecting eczema among schoolchildren in Adana and Payas, Hatay. The prevalence survey was conducted in schoolchildren aged 6-18 years old. The questionnaire was based on the ISAAC questionnaires and was distributed among primary and secondary schoolchildren. If the children were younger than 12 years of age their parent completed the questionnaire. This study was done among 3164 students in Adana (51.9 % boys, 48.1 % girls) and among 1353 students in Payas (% 49.5 boys, 50.5 % girls). The prevalence of eczema was found 8.3 % in Adana and 9.3 % in Payas. The family histories of atopy, dampness at home, allergic rhinitis, bronchitis, rhinitis, history of frequent sinusitis, rhinitis and sinusitis in the last year were found to be significantly higher in both cities. On the other hand, the heating systems, sexuality, father smoking habits, the smoking habits at home, presence of domestic animals at home weren't important for eczema in both the cities. In addition toys made out of feather's, smoking habits among mother's were found to be significantly higher for eczema in Payas, but it wasn't same for Adana. In comparison to children aged 15-18 years among eczema children, the age group 6-10 and one or more packet of cigarette smoking at home was higher risk in Adana but there weren't the same risks among student in Payas