67 research outputs found
Counting rational points on a Grassmannian
We prove an estimate on the number of rational points on the Grassmannian
variety of bounded twisted height, refining the classical result of Thunder
([21]) over the rational field: most importantly, our formula counts all
points. Among the consequences are a couple of new implications on the
classical subject of counting rational points on flag varieties.Comment: Fixed more minor errors, plus a proof for the counting formula on a
flag variet
A physical study of the LLL algorithm
This paper presents a study of the LLL algorithm from the perspective of
statistical physics. Based on our experimental and theoretical results, we
suggest that interpreting LLL as a sandpile model may help understand much of
its mysterious behavior. In the language of physics, our work presents evidence
that LLL and certain 1-d sandpile models with simpler toppling rules belong to
the same universality class.
This paper consists of three parts. First, we introduce sandpile models whose
statistics imitate those of LLL with compelling accuracy, which leads to the
idea that there must exist a meaningful connection between the two. Indeed, on
those sandpile models, we are able to prove the analogues of some of the most
desired statements for LLL, such as the existence of the gap between the
theoretical and the experimental RHF bounds. Furthermore, we test the formulas
from the finite-size scaling theory (FSS) against the LLL algorithm itself, and
find that they are in excellent agreement. This in particular explains and
refines the geometric series assumption (GSA), and allows one to extrapolate
various quantities of interest to the dimension limit. In particular, we
predict the empirical average RHF converges to as dimension
goes to infinity.Comment: Augmented version of 1804.03285; expect some overlap
A Facile Fabrication and Transfer Method of Vertically Aligned Carbon Nanotubes on a Mo/Ni Bilayer for Wearable Energy Devices
Carbon nanotubes are a promising material for flexible/wearable electrochemical device due to their mechanical softness, chemical stability, and high conductivity. Furthermore, the vertically aligned form of carbon nanotubes (VACNTs) have a large surface area due to their unique three-dimensional (3D) nanostructure. Thus, VACNTs are particularly useful for wearable electrochemical sensors and/or energy devices. However, VACNTs are generally grown via a high-temperature chemical vapor deposition process, which requires a rigid substrate. As a flexible/wearable device platform, therefore, VACNTs should be transferred from rigid substrates to soft substrates. Here, a facile fabrication and transfer method of a unique 3D nanostructure, that is, VACNTs on the Mo/Ni bilayer, for high performance flexible/wearable devices is reported. After growth of VACNTs on a Mo/Ni bilayer, VACNTs with the Mo/Ni bilayer can be easily peeled-off from the SiO2 wafer by using weak adhesion of Ni to SiO2 for transfer printing onto polymeric/elastomeric substrates. Moreover, the Mo layer helps facile growth of VACNTs, and the Mo/Ni bilayer underneath VACNTs maximizes the lateral current flow. The proposed 3D nanostructure (VACNTs on the Mo/Ni bilayer) is successfully applied as flexible electrodes for high-performance wearable asymmetric supercapacitors.
Wearable Fall Detector using Integrated Sensors and Energy Devices
Wearable devices have attracted great attentions as next-generation electronic devices. For the comfortable, portable, and easy-to-use system platform in wearable electronics, a key requirement is to replace conventional bulky and rigid energy devices into thin and deformable ones accompanying the capability of long-term energy supply. Here, we demonstrate a wearable fall detection system composed of a wristband-type deformable triboelectric generator and lithium ion battery in conjunction with integrated sensors, controllers, and wireless units. A stretchable conductive nylon is used as electrodes of the triboelectric generator and the interconnection between battery cells. Ethoxylated polyethylenimine, coated on the surface of the conductive nylon electrode, tunes the work function of a triboelectric generator and maximizes its performance. The electrical energy harvested from the triboelectric generator through human body motions continuously recharges the stretchable battery and prolongs hours of its use. The integrated energy supply system runs the 3-axis accelerometer and related electronics that record human body motions and send the data wirelessly. Upon the unexpected fall occurring, a custom-made software discriminates the fall signal and an emergency alert is immediately sent to an external mobile device. This wearable fall detection system would provide new opportunities in the mobile electronics and wearable healthcare.
LLL and stochastic sandpile models
We introduce stochastic sandpile models which imitate numerous aspects of the practical behavior of the LLL algorithm with compelling accuracy. In addition, we argue that the physics and mathematics of sandpile models provide satisfactory heuristic explanations to much of the mysteries of LLL, and pleasant implications for lattice-based cryptography as a whole. Based on these successes, we suggest a paradigm in which one regards blockwise reduction algorithms as 1-d stochastic self-organized criticality(SOC) models and study them as such
Spatiotemporally controlled drug delivery via photothermally driven conformational change of self-integrated plasmonic hybrid nanogels
Background
Spatiotemporal regulation is one of the major considerations for developing a controlled and targeted drug delivery system to treat diseases efficiently. Light-responsive plasmonic nanostructures take advantage due to their tunable optical and photothermal properties by changing size, shape, and spatial arrangement.
Results
In this study, self-integrated plasmonic hybrid nanogels (PHNs) are developed for spatiotemporally controllable drug delivery through light-driven conformational change and photothermally-boosted endosomal escape. PHNs are easily synthesized through the simultaneous integration of gold nanoparticles (GNPs), thermo-responsive poly (N-isopropyl acrylamide), and linker molecules during polymerization. Wave-optic simulations reveal that the size of the PHNs and the density of the integrated GNPs are crucial factors in modulating photothermal conversion. Several linkers with varying molecular weights are inserted for the optimal PHNs, and the alginate-linked PHN (A-PHN) achieves more than twofold enhanced heat conversion compared with others. Since light-mediated conformational changes occur transiently, drug delivery is achieved in a spatiotemporally controlled manner. Furthermore, light-induced heat generation from cellular internalized A-PHNs enables pinpoint cytosolic delivery through the endosomal rupture. Finally, the deeper penetration for the enhanced delivery efficiency by A-PHNs is validated using multicellular spheroid.
Conclusion
This study offers a strategy for synthesizing light-responsive nanocarriers and an in-depth understanding of light-modulated site-specific drug delivery.This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (Ministry of Science, ICT and Future Planning, No. 2023R1A2C2003947) for S.L., D.K., H.K., and I.C. This work was supported by the Samsung Research Funding and Incubation Center for Future Technology (SRFC-IT1802-03) for S.L., J.Y., H.K., and I.C. This work was supported by Basic Science Research Program through the NRF funded by the MSIT (No. 2021R1F1A1062856) and was also supported by Regional Innovation Strategy (RIS) through the NRF funded by the Ministry of Education (MOE) (2021RIS-004) for S.K. and J.S
Development of theranostic dual-layered Au-liposome for effective tumor targeting and photothermal therapy
Abstract
Background
Photothermal therapy (PTT) is an emerging anti-cancer therapeutic strategy that generates hyperthermia to ablate cancer cells under laser irradiation. Gold (Au) coated liposome (AL) was reported as an effective PTT agent with good biocompatibility and excretory property. However, exposed Au components on liposomes can cause instability in vivo and difficulty in further functionalization.
Results
Herein, we developed a theranostic dual-layered nanomaterial by adding liposomal layer to AL (LAL), followed by attaching polyethylene glycol (PEG) and radiolabeling. Functionalization with PEG improves the in vivo stability of LAL, and radioisotope labeling enables in vivo imaging of LAL. Functionalized LAL is stable in physiological conditions, and 64Cu labeled LAL (64Cu-LAL) shows a sufficient blood circulation property and an effective tumor targeting ability of 16.4%ID gโ1 from in vivo positron emission tomography (PET) imaging. Also, intravenously injected LAL shows higher tumor targeting, temperature elevation in vivo, and better PTT effect in orthotopic breast cancer mouse model compared to AL. The tumor growth inhibition rate of LAL was 3.9-fold higher than AL.
Conclusion
Based on these high stability, in vivo imaging ability, and tumor targeting efficiency, LAL could be a promising theranostic PTT agent.
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