Results of Fetal Ultrasound Imaging and Doppler Ultrasound Study in Pregnant Women with Extragenital Pathology

The aim of this research was to study the parameters of fetal ultrasound imaging and Doppler ultrasound study in pregnant women with extragenital diseases (EGDs) during the treatment regimes with and without hyperbaric oxygen therapy (HBOT). Materials and Methods: A total of 235 pregnant women were examined prospectively at 5 to 40 weeks of gestation. The main group included 191 women with EGDs (anemia, arterial hypertension, chronic pyelonephritis); the control group included 44 women with physiological pregnancy without EGDs. Evaluation of treatment efficacy was based on data from clinical and laboratory findings before treatment and after its completion. The following hardware methods of research were performed: ultrasonography, fetometry, dopplerometric study of fetoplacental complex. Results: Based on data obtained from this study, the following findings were made: - In the early stages of gestation, there were no disturbances in fetoplacental blood circulation. - Starting the 19th week of pregnancy, there is a significant increase in the uterine artery resistive index in pregnant women with arterial hypertension. - In women with a high perinatal risk on the background of the studied EGDs, the third trimester of pregnancy, despite the ongoing conventional treatment, is characterized by persistent impairment in fetoplacental blood circulation. - The inclusion of HBOT in complex therapy in the early stages of pregnancy in women with a high perinatal risk allows leveling out the inevitable disturbances in fetoplacental blood circulation on the background of the studied EGDs

Receiver-Operating Characteristic Analysis for Evaluating the Severity of the Condition of Preterm Children Depending on Perinatal Risk Factors, Timing, and Mode of Delivery

The aim of this study was to assess the role of the receiver-operating characteristic (ROC) analysis for evaluating the severity of the condition of preterm children, depending on perinatal risk (PR) factors, timing, and mode of delivery. In order to identify the thresholds for "intrapartum gain" of risk factors for timely selection of mode of delivery, we performed a comparative ROC analysis of the severity of the state of children at birth according to the Apgar score (AS), from 1 point in the first minute to 7 points in the fifth minute of life. The analysis of indicators of perinatal mortality (PM) and perinatal morbidity (PMb) shows a statistically significant difference (P<0.05) in the selection of the priority mode of delivery for women with premature birth during all analyzed gestation ages, depending on PR: frequency of PM and PMb is lower among pregnant women with a high risk who gave birth to premature babies delivered by C-section

Perinatal Outcomes in Women with Extragenital Diseases

An increase in the incidence of extragenital diseases (EGDs) in the population against the background of the rise in the birth rate actualizes the problems of pregnancy management in women with EGD. Pregnancy-induced physiological changes in the body lead to a worsening of the course of diseases that were at the stage of unsustainable compensation before pregnancy. The purpose of our study was to determine the effectiveness of hyperbaric oxygenation (HBO) in the prevention of obstetric/perinatal complications in pregnant women with EGDs and neonatal morbidity. The inclusion of HBO in a complex of therapeutic and prophylactic measures in pregnant women with high perinatal risk contributed to a significant reduction in premature birth and a statistically significant improvement in neonatal morbidity parameters

Results of Fetal Ultrasound Imaging and Doppler Ultrasound Study Depending on the Factors of Perinatal Risk in Preterm Birth

Premature birth (PB) is associated with placental insufficiency, which is confirmed in the morphological study of the placenta. Ultrasonic markers of placental abnormalities, often preceding PB, have been identified: changes in placental structure, premature ripening of the placenta, oligohydramnios, and fetal-placental circulation