Evaluation of consistency rate between clinical and histopathological diagnosis of oral soft tissue lesions

BACKGROUND: Some of the oral lesions including malignant tumors of mesenchymal and epithelial origin have same clinical features. Most of them are white or red patches with undermined edge. Also, in some cases, the microscopic view of histopathologic examination is not diagnostic. So, the integration of clinical and pathological information leads to the correct diagnosis. The aim of this study was the evaluation of consistency rate between clinical and histopathological diagnosis of oral malignant tumors of mesenchymal and epithelial origin.METHODS: This cross-sectional retrospective study was performed in four centers of oral pathology of Hamedan University of Medical Sciences, Hamedan, Iran, during January to June, 2016. The data were collected using the archived files of patients. Collected data from the files included age, sex, lesion location, lesion type, and first and second clinical and histopathologic diagnosis. Finally, histopathological findings were compared with the first and second clinical diagnosis. Data were analyzed using SPSS software.RESULTS: Ninety-one and seventy-nine of studied files were related to men and women, respectively. Most frequent malignant lesion was related to squamous cell carcinoma (SCC) (52.9%), followed by melanoma (29.4%). The consistency rate of first and second clinical and histopathologic diagnosis was 68.2% and 15.2%, respectively. Higher consistency rate was observed in melanoma, SCC, and fibrosarcoma lesions.CONCLUSION: High inconsistency rate between clinical and histopathological diagnosis was found in some cases which may have originated from low diagnostic knowledge of clinicians or their misconception from misdiagnosis. Therefore, the improvement of knowledge and awareness of clinicians by conducting retraining courses is necessary

A Clinicopathological Report of Four Cases of Squamous Odontogenic Tumor-Like Proliferations in Odontogenic Cysts: Suggested Opinions regarding This Unusual Nature

Distinguishing squamous odontogenic tumor-like proliferations (SOTLPs) is important in odontogenic cysts to avoid misinterpretation such as a squamous odontogenic tumor, well-differentiated squamous cell carcinoma, and acanthomatous type of ameloblastoma. This study is aimed at reporting 4 cases of these clinicopathological proliferations in order to shed more light on the importance of distinguishing them from other similar types. 150 odontogenic cysts were studied in which four cases (2.66%) with SOTLPs were identified including 2 radicular cysts, 1 dentigerous cyst, and 1 odontogenic keratocyst. These proliferations were observed in the cysts’ wall particularly adjacent to the epithelial lining. All cysts had inflammation while 3 cases showed budding from the epithelial cyst lining. The findings suggested that lining of odontogenic cysts could be a source of SOTLPs, and inflammation probably played an effective role in their development. Its incidence was 2.66% in the present study. Although SOTLPs are not frequent in odontogenic cysts, their identification is important to prevent wrong histopathologic interpretation and treatment

The Effectiveness of Puppet Play Therapy Intervention on Social Skills of Male Students with Autism Disorder

The purpose of this study was to investigating of the effectiveness of puppet play therapy intervention on social skills of male students with autism disorder. The sample size was 24 male students with autism disorder that were selected by in available sampling method, and after a Garz test run they were assigned in to experimental and control group, randomly. Such as each group consist of 12 students. Both groups were assessed pre-test. The Experimental group received puppet play therapy training in 21 sessions while control group did not. After completion of intervention period for experimental group the post-test was administered for both groups. The Stone`s social skills Scale were administered to assess the social skills. The data analyses by analysis of covariance (ANCOVA) and multivariate analysis of covariance (MANCOVA) showed that there were significantly increase in the mean scores of social skills and subscales (understanding/perspective taking, initiating interactions, responding to interaction and maintaining interactions) in experimental group (P<0.01).Observations implied the interference of puppet play therapy intervention for improving social skills of male students with autism spectrum disorder. The findings not only confirmed the effectiveness of this method, but also opens up the wider and deeper approach to puppet play therapy intervention and encourages therapists to consider puppet play therapy intervention as an effective therapy for students with autism disorder

3D-Printed Soft Membrane for Periodontal Guided Tissue Regeneration

Objectives: The current study aimed to perform an in vivo examination using a critical-size periodontal canine model to investigate the capability of a 3D-printed soft membrane for guided tissue regeneration (GTR). This membrane is made of a specific composition of gelatin, elastin, and sodium hyaluronate that was fine-tuned and fully characterized in vitro in our previous study. The value of this composition is its potential to be employed as a suitable replacement for collagen, which is the main component of conventional GTR membranes, to overcome the cost issue with collagen. Methods: Critical-size dehiscence defects were surgically created on the buccal surface of the roots of canine bilateral mandibular teeth. GTR treatment was performed with the 3D-printed membrane and two commercially available collagen membranes (Botiss Jason® and Smartbrane-Regedent membranes) and a group without any membrane placement was considered as the control group. The defects were submerged with tension-free closure of the gingival flaps. Histologic and histometric analyses were employed to assess the periodontal healing over an 8-week experimental period. Results: Histometric evaluations confirmed higher levels of new bone formation in the 3D-printed membrane group. Moreover, in all defects treated with the membranes, the formation of periodontal tissues, bone, periodontal ligaments, and cementum was observed after 8 weeks, while in the control group, only connective tissue was found in the defect sites. There was no clinical sign of inflammation or recession of gingiva in any of the groups. Significance: The 3D-printed gelatin/elastin/sodium hyaluronate membrane can be safe and effective for use in GTR for periodontal tissue regeneration therapies, with better or comparable results to the commercial collagen membranes