El expresionismo en ladrillo del norte de Alemania: un acercamiento a Fritz Schumacher y Fritz Höger

Este Trabajo Final de Grado aborda la corriente expresionista de la arquitectura, que, contando con su foco más activo en Alemania, la producción de algunos de los arquitectos no ha tenido demasiada repercusión a nivel bibliográfico fuera de su entorno nacional. Se hace, por tanto, una revisión del discurso histórico del Expresionismo, para entender su grado de marginación, así como se reevalúa su relación con la Nueva Objetividad, revindicando el papel del mismo como Arquitectura Moderna. Se intenta revisar esta arquitectura, realizando un pequeño acercamiento global, para, contextualizada, centrarse en la producida en el Norte de Alemania. Se estudian sus influencias principales y se aportan algunos ejemplos significativos, destacando las figuras de Fritz Höger y Fritz Schumacher. Se revisan sus trayectorias para entender su papel en la época de las vanguardias y se analizan algunas de sus obras más significativas, profundizando en la Chilehaus de Höger y el Krematorium en Ohlsdorf de Schumacher, ambas en Hamburgo. Con esto se pretende completar nuestra propia visión de aquel momento histórico, y rescatar sus posibles valores materiales para la arquitectura contemporánea.The following paper address the expressionist architectural stream, which main focus is located in Germany. Outside their national borders, the work of some architects remains unknown due to a lack of diffusion. In order to understand this exclusion, a revaluation of the historical discourse is made, along with a revision of the relation between Expressionism and New Objetivity architecture. Here, a deman of the Expressionism architecture as part of the Modern Architecture is defended. Then follows a brief global approach to the stream, that onces contextualized, focus on the one created in North Germany. Their main influences are studied as well as some significant examples, paying special consideration to Fritz Höger und Fritz Schumacher. Their professional careers are analysed as a way to understand their role at that time, in particular the Höger’s Chilehaus and Schumacher’s Krematorium in Ohlsdorf, both located in Hamburg. With this, a reinterpretation of this architecture is aimed, longing for a wider vision on the toppic and hoping that it may be useful for the contemporary architecture.Universidad de Sevilla. Grado en Arquitectur

PASIÓN Y ADICCIÓN AL TRABAJO: UNA INVESTIGACIÓN PSICOMÉTRICA Y PREDICTIVA.

Antecedents: L’Addicció al treball i la Passió pel treball tenen una gran influència en la salut laboral dels treballadors. En aquest context, els objectius plantejats són tres: (1) L'adaptació al castellà de l'Escala de Passió pel Treball (PTW) de Vallerand i Houlfort i el Qüestionari d'Estils de Vida (HPLP-II) de Walker i Hill-Polerecky; (2) Determinar si la Passió pel treball i l'Addicció al treball són constructes diferents; i (3) Identificar la capacitat predictiva de variables criteri sobre l'Addicció al treball i la Passió pel treball. Mètode: Els participants han estat 513 treballadors de Catalunya, obtinguts mitjançant un mostreig no probabilístic. S'han utilitzat els programes FACTOR (versió 7.2) i SPSS 20.0. Resultats: En l'escala PTW, els resultats del AFC (ESEM) recolzen el model de dos factors (Passió Harmoniosa i Passió Obsessiva). En l'escala sobre estil de vida (HPLP-II) l'estructura interna es redueix de sis a quatre factors (Responsabilitat cap a la salut, Activitat física, Nutrició, i Creixement espiritual i relacions interpersonals). Les dues escales presenten una fiabilitat adequada i indicis de validesa amb: Burnout, Irritació, Engagement i Autoeficàcia. A més, queda demostrada que l'Addicció al treball i la Passió pel treball són constructes diferents. També, es determina la capacitat predictiva de variables com a Personalitat, Engagement, Autoeficàcia, ICO, Satisfacció per la vida i Estil de vida sobre l'Addicció al treball i la Passió pel treball. Conclusions: Les Escala PTW i el Qüestionari HPLP-II, són instruments fiables i vàlids, adequats per ser usats en castellà. L'Addicció al Treball i la Passió pel Treball són constructes diferents. L'Addicció al Treball i la Passió pel Treball es poden predir mitjançant determinades variables (Personalitat, Engagement, Autoeficàcia, ICO, Satisfacció per la Vida i Estil de Vida).Antecedentes: La Adicción al trabajo y la Pasión por el trabajo tienen una gran influencia en la salud laboral de los trabajadores. En este contexto, los objetivos planteados son tres: (1) La adaptación al castellano de la Escala de Pasión por el Trabajo (PTW) de Vallerand y Houlfort y el Cuestionario de Estilos de Vida (HPLP-II) de Walker y Hill-Polerecky; (2) Determinar si la Pasión por el trabajo y la Adicción al trabajo son constructos diferentes; y (3) Identificar la capacidad predictiva de variables criterio sobre la Adicción al trabajo y la Pasión por el trabajo. Método: Los participantes han sido 513 trabajadores de Cataluña, obtenidos mediante un muestreo no probabilístico. Se han utilizado los programas FACTOR (versión 7.2) y SPSS 20.0. Resultados: En la escala PTW, los resultados del AFC (ESEM) apoyan el modelo de dos factores (Pasión Armoniosa y Pasión Obsesiva). En la escala sobre estilo de vida (HPLP-II) la estructura interna se reduce de seis a cuatro factores (Responsabilidad hacia la salud, Actividad física, Nutrición, y Crecimiento espiritual y relaciones interpersonales). Las dos escalas presentan una fiabilidad adecuada e indicios de validez con: Burnout, Irritación, Engagement y Autoeficacia. Además, queda demostrada que la Adicción al trabajo y la Pasión por el trabajo son constructos diferentes. También, se determina la capacidad predictiva de variables como Personalidad, Engagement, Autoeficacia, ICO, Satisfacción por la vida y Estilo de vida sobre la Adicción al trabajo y la Pasión por el trabajo. Conclusiones: Las Escala PTW y el Cuestionario HPLP-II, son instrumentos fiables y válidos, adecuados para ser usados en castellano. La Adicción al Trabajo y la Pasión por el Trabajo son constructos diferentes. La Adicción al Trabajo y la Pasión por el Trabajo se pueden predecir mediante determinadas variables (Personalidad, Engagement, Autoeficacia, ICO, Satisfacción por la Vida y Estilo de Vida).Background: Workaholism and passion at work have a great influence on the occupational health of workers. In this context, the objectives are threefold: (1) Adapting to Spanish the Passion for Work Scale (PTW) (Vallerand Houlfort) and the Lifestyle Questionnaire (HPLP-II) (Hill-Walker Polerecky); (2) Determining whether the Passion at work and Workaholism are different constructs; and (3) Identifying the predictive ability of criterion variables on Workaholism and Passion at work. Method: Participants were 513 workers in Catalonia, obtained using a non-probability sampling. We used the FACTOR program (version 7.2) and SPSS 20.0. Results: In the PTW scale, the results of the AFC (ESEM) supported the two-factor model (Harmonious Passion and Obsessive Passion). On the lifestyle scale (HPLP-II) the internal structure is reduced from six to four factors (Responsibility towards health, Physical activity, Nutrition, and Spiritual growth and interpersonal relationships). The two scales have adequate reliability and evidence of validity with Burnout, Irritation, Engagement and Self-Efficacy. Furthermore, it is demonstrated that Workaholism and Passion at work are different constructs. The predictive power of variables such as Personality, Engagement, Self-Efficacy, ICO, Life satisfaction and Lifestyle on Workaholism and Passion at work is also determined. Conclusions: PTW Scale and Questionnaire HPLP-II, are reliable and valid instruments, suitable to be uses in Spanish. The Workaholism and Passion at work are different constructs. Workaholism and Passion at work can be predicted by certain variables (Personality, Engagement, Self-Efficacy, ICO, Life satisfaction and Lifestyle)

Extracellular vesicle PD‑L1 dynamics predict durable response to immune‑checkpoint inhibitors and survival in patients with non‑small cell lung cancer

Background: Immune-checkpoint inhibitors (ICIs) changed the therapeutic landscape of patients with lung cancer. However, only a subset of them derived clinical benefit and evidenced the need to identify reliable predictive biomarkers. Liquid biopsy is the non-invasive and repeatable analysis of biological material in body fluids and a promising tool for cancer biomarkers discovery. In particular, there is growing evidence that extracellular vesicles (EVs) play an important role in tumor progression and in tumor-immune interactions. Thus, we evaluated whether extracellular vesicle PD-L1 expression could be used as a biomarker for prediction of durable treatment response and survival in patients with non-small cell lung cancer (NSCLC) undergoing treatment with ICIs. Methods: Dynamic changes in EV PD-L1 were analyzed in plasma samples collected before and at 9 ± 1 weeks during treatment in a retrospective and a prospective independent cohorts of 33 and 39 patients, respectively. Results: As a result, an increase in EV PD-L1 was observed in non-responders in comparison to responders and was an independent biomarker for shorter progression-free survival and overall survival. To the contrary, tissue PD-L1 expression, the commonly used biomarker, was not predictive neither for durable response nor survival. Conclusion: These findings indicate that EV PD-L1 dynamics could be used to stratify patients with advanced NSCLC who would experience durable benefit from ICIs.Center for Thoracic Oncology Icahn School of Medicine at Mount SinaiBorsa Dottorati FSE XXXII ciclo UnimeUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) P30CA016672University of Pittsburgh Hillman Cancer CenterHillman Cancer Center's NCI Cancer Center Support Grant (CCSG) P30CA047904A.S.S.O. (Associazione Siciliana Sostegno Oncologico) OnlusNational Cancer Institute-Cancer Center Support Grant (CCSG) P30CA134274Merck & Compan

An educational experience with digital storytelling in a classroom of early childhood education for the development of the digital competence

Presentamos un cuento electrónico que hemos diseñado sobre las Tecnologías de la Información y la Comunicación para alumnos de Educación Infantil. Este recurso multimedia, al que hemos denominado el cuento de Los TICinventos, se contextualiza dentro de una experiencia innovadora desarrollada para favorecer la competencia digital de estos niños y secundariamente, su competencia comunicativa. El trabajo se ha llevado a cabo, en una primera fase, en un centro público de Educación Infantil y Primaria de la Región de Murcia. Los análisis cualitativos de la información obtenida mediante los dibujos de los niños y las manifestaciones verbales de éstos y su maestra, ponen de manifiesto el valor didáctico de la experiencia y que los aprendizajes relativos a las citadas competencias se producen. En esta comunicación explicamos el proceso de diseño y elaboración del cuento eléctronico adaptándolo a las características personales y de aprendizaje del alumnado de esta etapa educativa

MAP17 (PDZK1IP1) and pH2AX are potential predictive biomarkers for rectal cancer treatment efficacy

Rectal cancer represents approximately 10% of cancers worldwide. Preoperative chemoradiotherapy increases complete pathologic response and local control, although it offers a poor advantage in survivorship and sphincter saving compared with that of radiotherapy alone. After preoperative chemoradiotherapy, approximately 20% of patients with rectal cancer achieve a pathologic complete response to the removed surgical specimen; this response may be related to a better prognosis and an improvement in disease-free survival. However, better biomarkers to predict response and new targets are needed to stratify patients and obtain better response rates. MAP17 (PDZK1IP1) is a small, 17 kDa non-glycosylated membrane protein located in the plasma membrane and Golgi apparatus and is overexpressed in a wide variety of human carcinomas. MAP17 has been proposed as a predictive biomarker for reactive oxygen species, ROS, inducing treatments in cervical tumors or laryngeal carcinoma. Due to the increase in ROS, MAP17 is also associated with the marker of DNA damage, phosphoH2AX (pH2AX). In the present manuscript, we examined the values of MAP17 and pH2AX as surrogate biomarkers of the response in rectal tumors. MAP17 expression after preoperative chemoradiotherapy is able to predict the response to chemoradiotherapy, similar to the increase in pH2AX. Furthermore, we explored whether we can identify molecular targeted therapies that could help improve the response of these tumors to radiotherapy. In this sense, we found that the inhibition of DNA damage with olaparib increased the response to radio- and chemotherapy, specifically in tumors with high levels of pH2AX and MAP17.Spanish Ministry of Economy and Competitivity, Plan Estatal de I+D+I 2013–2016, ISCIII (Fis: PI15/00045) and CIBER de Cáncer (CB16/12/00275)co-funded by FEDER from Regional Development European Funds (European Union), Consejería de Ciencia e Innovación (CTS-1848)Consejería de Salud of the Junta de Andalucía (PI-0096–2014)

Wage differentials and segmentation: The impact of institutions and changing economic conditions.

This paper uses data from the European Survey on Income and Living Conditions to offer new empirical evidence on how wage differentials are influenced by the changing economic conditions, that is, before and after the 2008–2010 recession, and shaped by the different institutional frameworks of European Union countries. We examine whether wage changes are homogeneous across groups of workers, as they are classified by their contractual relationship and working time, and by the heterogeneity in institutions that regulate and affect the labour market. Results obtained by estimating ordinary least squares and quantile regressions confirm the existence of contract and working time wage gaps and allow to estimate their different magnitudes along the wage distribution, and their rise during the recession. The impact of labour market institutions on shaping them is diverse, with more intervention of the government in the setting of the minimum wage and stricter regulation for atypical contracts reducing the wage gaps and producing larger positive effects for low-wage employees

La casa de piedra en la cuenca del río Alberche

En número dedicado a: La provincia de Ávil

Labour flows in the EU at the beginning of the crisis

Artículo de revist

Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast

In the present article, we describe a study of antitumor activity in breast cell lines using silver nanoparticles (Ag NPs) synthesized by a microbiological method. These Ag NPs were tested for their antitumor activity against MCF7 and T47D cancer cells and MCF10-A normal breast cell line. We analyzed cell viability, apoptosis induction, and endocytosis activity of those cell lines and we observed that the effects of the biosynthesized Ag NPs were directly related with the endocytosis activity. Moreover, Ag NPs had higher inhibition efficacy in tumor lines than in normal lines of breast cells, which is due to the higher endocytic activity of tumor cells compared to normal cells. In this way, we demonstrate that biosynthesized Ag NPs can be an alternative for the treatment of tumors.Support from Universidad Nacional de San Luis, to the Agencia Nacional de Promoción Científica y Tecnológica, from Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) (Argentina), and from GENYO, Centre for Genomics and Oncological Research: Pfizer-University of Granada, Andalusian Regional Government, Granada, Spain are acknowledged

A Poglut1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss

Skeletal muscle regeneration by muscle satellite cells is a physiological mechanism activated upon muscle damage and regulated by Notch signaling. In a family with autosomal recessive limbgirdle muscular dystrophy, we identified a missense mutation in POGLUT1 (protein O-glucosyltransferase 1), an enzyme involved in Notch posttranslational modification and function. In vitro and in vivo experiments demonstrated that the mutation reduces Oglucosyltransferase activity on Notch and impairs muscle development. Muscles from patients revealed decreased Notch signaling, dramatic reduction in satellite cell pool and a muscle-specific adystroglycan hypoglycosylation not present in patients’ fibroblasts. Primary myoblasts from patients showed slow proliferation, facilitated differentiation, and a decreased pool of quiescent PAX7+ cells. A robust rescue of the myogenesis was demonstrated by increasing Notch signaling. None of these alterations were found in muscles from secondary dystroglycanopathy patients. These data suggest that a key pathomechanism for this novel form of muscular dystrophy is Notch-dependent loss of satellite cells.Junta de Andalucía PI-0017-201