Deferred and atomic setting of scheduling attributes for ada

© Sáez Barona, S.; Real Sáez, J.; Crespo, A. | ACM, 2015. This is the author's version of the work. It is posted here for your personal use. Not for redistribution. The definitive Version of Record was published in Adda Letters, http://dx.doi.org/10.1145/2552999.2553010Deferred setting of scheduling attributes refers to a single operation that sets a new value for a scheduling attribute of a task at some future time. Although deferred setting of scheduling attributes is possible in Ada 2012, it is in a rather limited way: only deadline or CPU can be changed deferredly, either at a specified time or when the task is released from a suspension object. And only one of those two attributes at a time. Other scheduling attributes such as priority cannot have deferred setting by means of a single operation. This would be a convenient feature to have for schemes such as job partitioning, task splitting, or mode changes. Another issue is the absence of operations for atomically changing several parameters at a time, which would avoid scheduling issues specially on multiprocessors. In this paper we explore a proposal aimed at correcting these two drawbacks. On one hand, we want to be able to change more attributes, not only deadlines, deferredly or immediately. On the other hand, we want to atomically change (now or later) a set of attributes, thereby avoiding scheduling artifacts that arise from sequentially changing several attributes, specially when the CPU is one of them. Rather than providing a number of library operations for postponing the setting of a variety of scheduling attributes, we propose to encapsulate the scheduling attributes of each task i n a single t agged type that can be extended with more attributes for specific applications if neededSáez Barona, S.; Real Sáez, JV.; Crespo, A. (2013). Deferred and atomic setting of scheduling attributes for ada. Ada Letters. 33(2):97-108. doi:10.1145/2552999.2553010S9710833

Bio- and magnetostratigraphic correlation of the Miocene primate bearing site of Castell de Barber a to the earliest Vallesian

Castell de Barberà, located in the Vallès-Penedès Basin (NE Iberian Peninsula), is one of the few European sites where pliopithecoids (Barberapithecus) and hominoids (cf. Dryopithecus) co-occur. The dating of this Miocene site has proven controversial. A latest Aragonian (MN7+8, ca. 11.88-11.18 Ma) age was long accepted by most authors, despite subsequent reports of hipparionin remains that signaled a Vallesian age. On the latter basis, Castell de Barberà was recently correlated to the early Vallesian (MN9, ca. 11.18-10.3 Ma) on tentative grounds. Uncertainties about the provenance of the Hippotherium material and the lack of magnetostratigraphic data precluded more accurate dating. After decades of inactivity, fieldwork was resumed in 2014-2015 at Castell de Barberà, including the original layer (CB-D) that in the past delivered most of the fossils. Here we report magnetostratigraphic results for the original outcrop and another nearby section. Our results indicate that CB-D is located in a normal polarity magnetozone at about midheight of a short (~20 m-thick) stratigraphic section. The composite magnetostratigraphic section (~50 m) has as many as four to six magnetozones. These multiple reversals, coupled with the in situ recovery of a Hippotherium humerus from CB-D in 2015, make it very unlikely the correlation of any of the sampled normal polarity magnetozones with the long normal polarity subchron C5n.2n (11.056-9.984 Ma), which is characteristic of the early Vallesian. Our results support instead a correlation of CB-D with C5r.1n (11.188-11.146 Ma), where the Aragonian/Vallesian boundary is situated, and therefore indicate an earliest Vallesian age of ~11.2 Ma for Castell de Barberà. Our results settle the longstanding debate about the Aragonian vs. Vallesian age of this site, which appears roughly coeval with the Creu de Conill 20 locality (11.18 Ma), where hipparionins are first recorded in the Vallès- Penedès Basi

Comparison of selectivity of a family of chelating agents for trivalent (Al³⁺, Fe³⁺) and bivalent (Cu²⁺, Zn²⁺) metal ions

Chelation therapy is used for the treatment of metal intoxication in humans. Selectivity towards the target metal ion is one important characteristic of the chelating agent. In the frame of our research of chelating agents for iron and aluminium, we synthesized five new ligands (Figure 1), and studied their behavior toward the trivalent metal ions. L4, L5, L6 and L8 were found to be excellent ligands for the coordination of Fe3+ and Al3+. We are presenting here a study on the same ligands with the two essential bivalent metal ions, Zn2+ and Cu2+. The results of spectrophotometric, potentiometric, and NMR measurements performed to determine the equilibrium formation constants will be presented. The speciation of the complexes with the trivalent metal ions in presence of endogenous zinc and copper will be discussed

Pre-transplant donor-specific T-cell alloreactivity is strongly associated with early acute cellular rejection in kidney transplant recipients not receiving T-cell depleting induction therapy

Preformed T-cell immune-sensitization should most likely impact allograft outcome during the initial period after kidney transplantation, since donor-specific memory T-cells may rap- idly recognize alloantigens and activate the effector immune response, which leads to allo- graft rejection. However, the precise time-frame in which acute rejection is fundamentally triggered by preformed donor-specific memory T cells rather than by denovo activated na ï ve T cells is still to be established. Here, preformed donor-specific alloreactive T-cell re- sponses were evaluated using the IFN- γ ELISPOT assay in a large consecutive cohort of kidney transplant patients (n = 90), to assess the main clinical variables associated with cel- lular sensitization and its predominant time-frame impact on allograft outcome, and was fur- ther validated in an independent new set of kidney transplant recipients (n = 67). We found that most highly T-cell sensitized patients were elderly patients with particularly poor HLA class-I matching, without any clinically recognizable sensitizing events. While one-year inci- dence of all types of biopsy-proven acute rejection did not differ between T-cell alloreactive and non-alloreactive patients, Receiver Operating Characteristic curve analysis indicated the first two months after transplantation as the highest risk time period for acute cellular re- jection associated with baseline T-cell sensitization. This effect was particularly evident in young and highly alloreactive individuals that did not receive T-cell depletion immunosup- pression. Multivariate analysis confirmed preformed T-cell sensitization as an independent predictor of early acute cellular rejection. In summary, monitoring anti-donor T-cell sensiti- zation before transplantation may help to identify patients at increased risk of acute cellular rejection, particularly in the early phases after kidney transplantation, and thus guide decision-making regarding the use of induction therapy

Dataset on the activation of Muller cells through macrophages upon hypoxia in the retina

The dataset presented in this article complements the article entitled “Myeloid cells contribute indirectly to VEGF expression upon hypoxia via activation of Müller cells” (C. Nürnberg, N. Kociok, C. Brockmann, T. Lischke, S. Crespo-Garcia, N. Reichhart, S. Wolf, R. Baumgrass, S.A. Eming, S. Beer- Hammer, and A.M. Joussen). This complementary dataset provides further insight into the experimental validation of the VEGFfl/fl LysMCre (here named VEGFmcko) knockout model used in the main article through genomic and quantitative Real-Time PCR in various murine tissues as well as additional flow cytometry data and immunohistochemical stainings. By providing these data, we aim to enable researcher to reproduce and critically analyze our data

Experiencias y percepciones de los donantes de sangre sobre la donación en un hospital público de Perú

Objetivo: Conocer las experiencias y percepciones de donantes de sangre en un hospital público. Materiales y métodos: Se realizó un estudio cualitativo con orientación fenomenológica en un hospital público de Lima. Se realizaron entrevistas semiestructuradas a profundidad y notas de campo basadas en observaciones a los participantes. Resultados: Se entrevistó a doce donantes, los cuales manifestaron no haber tenido mucha información sobre la donación y el banco de sangre. Sin embargo, luego de su experiencia de donar se identificó aspectos positivos como la atención de calidad, rápida y minuciosa. Los participantes valoran el trato cordial del personal a la hora de brindar información, el reducido tiempo de espera y la compañía durante el proceso de extracción de la sangre. Los aspectos negativos fueron la falta de publicidad y difusión de la donación voluntaria de sangre. A pesar de ello la mayoría de entrevistados manifestaron su intención de retornar debido a la calidad del servicio. En resumen, la percepción de los participantes fue favorable a la donación, al recibir una atención de calidad, con información oportuna en el tiempo adecuado. Conclusiones: Los entrevistados no tenían mayor información sobre la posibilidad de hacer donaciones voluntarias de sangre en el hospital. Posterior a su experiencia, la percepción sobre la donación fue favorable, indicando su intención de participar en futuras donaciones

Lack of netrin-4 modulates pathologic neovascularization in the eye

Netrins are a family of matrix-binding proteins that function as guidance signals. Netrin-4 displays pathologic roles in tumorigenesis and neovascularization. To answer the question whether netrin-4 acts either pro- or anti-angiogenic, angiogenesis in the retina was assessed in Ntn-4−/− mice with oxygen-induced retinopathy (OIR) and laser-induced choroidal neovascularization (CNV), mimicking hypoxia-mediated neovascularization and inflammatory mediated angiogenesis. The basement membrane protein netrin-4 was found to be localised to mature retinal blood vessels. Netrin-4, but not netrin-1 mRNA expression, increased in response to relative hypoxia and recovered to normal levels at the end of blood vessel formation. No changes in the retina were found in normoxic Ntn-4−/− mice. In OIR, Ntn-4−/− mice initially displayed larger avascular areas which recovered faster to revascularization. Ganzfeld electroretinography showed faster recovery of retinal function in Ntn-4−/− mice. Expression of netrin receptors, Unc5H2 (Unc-5 homolog B, C. elegans) and DCC (deleted in colorectal carcinoma), was found in Müller cells and astrocytes. Laser-induced neovascularization in Nnt-4−/− mice did not differ to that in the controls. Our results indicate a role for netrin-4 as an angiogenesis modulating factor in O2-dependent vascular homeostasis while being less important during normal retinal developmental angiogenesis or during inflammatory neovascularization

Lack of netrin-4 modulates pathologic neovascularization in the eye

Netrins are a family of matrix-binding proteins that function as guidance signals. Netrin-4 displays pathologic roles in tumorigenesis and neovascularization. To answer the question whether netrin-4 acts either pro- or anti-angiogenic, angiogenesis in the retina was assessed in Ntn-4−/− mice with oxygen-induced retinopathy (OIR) and laser-induced choroidal neovascularization (CNV), mimicking hypoxia-mediated neovascularization and inflammatory mediated angiogenesis. The basement membrane protein netrin-4 was found to be localised to mature retinal blood vessels. Netrin-4, but not netrin-1 mRNA expression, increased in response to relative hypoxia and recovered to normal levels at the end of blood vessel formation. No changes in the retina were found in normoxic Ntn-4−/− mice. In OIR, Ntn-4−/− mice initially displayed larger avascular areas which recovered faster to revascularization. Ganzfeld electroretinography showed faster recovery of retinal function in Ntn-4−/− mice. Expression of netrin receptors, Unc5H2 (Unc-5 homolog B, C. elegans) and DCC (deleted in colorectal carcinoma), was found in Müller cells and astrocytes. Laser-induced neovascularization in Nnt-4−/− mice did not differ to that in the controls. Our results indicate a role for netrin-4 as an angiogenesis modulating factor in O2-dependent vascular homeostasis while being less important during normal retinal developmental angiogenesis or during inflammatory neovascularization

Los vertebrados fosiles del Abocador de Can Mata (els Hostalets de Pierola, l'Anoia, CataluÑa), una sucesion de localidades del Aragoniense superior (MN6 y MN7+8) de la cuenca del Valles-Penedes. CampaÑas 2002-2003, 2004-2005

Se presenta una síntesis del registro de vertebrados fósiles del Abocador de Can Mata (els Hostalets de Pierola, cuenca neógena del Vallès-Penedès), con especial énfasis en los aspectos taxonómico y bioestratigráfico. Este macroyacimiento incluye por el momento una sucesión de 91 localidades de micro- y/o macrovertebrados muestreadas, repartidas a lo largo de unos 300 m de serie estratigráfica, abarcando un intervalo de tiempo de más de un millón de años correspondiente al Aragoniense superior. Durante los 28 meses de trabajo de campo desarrollados a lo largo de las campañas 2002-2003, 2004 y 2005, se han recuperado más de 15.000 restos de macrovertebrados fósiles y más de 1.300 dientes de micromamíferos (cantidad que se verá incrementada en el futuro cuando haya finalizado el lavado y triado de los sedimentos acumulados). Se presenta por primera vez una lista exhaustiva del conjunto de localidades y su contextualización estratigráfica, además de una lista faunística actualizada y una propuesta de biozonación local. La gran riqueza fosilífera de la zona y el enorme esfuerzo de muestreo, combinados con los requerimientos de la legislación vigente sobre protección del patrimonio paleontológico, explican el éxito de la intervención paleontológica. En conjunto, la ampliación del vertedero de Can Mata, con el adecuado control paleontológico, proporciona una oportunidad única para investigar la composición faunística de los ecosistemas terrestres del Aragoniense superior en el suroeste de Europa