Analysis of Lyα dielectronic satellites to characterize temporal profile of intense femtosecond laser pulses

In the paper, an X-ray spectroscopy-based approach on laser pulse temporal profile characterization is described. The structure of dielectronic satellites to H-like Lyα lines strongly depends on a plasma electron density, so it can be applied for diagnostics. These spectral lines are mainly emitted during initial stage of laser plasma expansion. It means that plasma parameters obtained via them characterizes matter conditions in a region surrounding a spot of laser-matter interaction. In the case when a laser contrast is high enough, the radiation interacts with cold matter, which had not been preliminary perturbed by a laser prepulse, and the satellites structure shape corresponding to high densities should be observed. It allows us to consider the satellites as a diagnostic tool for the laser temporal profile quality. In the paper dependencies of the dielectronic satellites structure on electron densities obtained from detailed kinetic calculations in the wide range of plasma parameter for different elements are under discussion. Fundamental theoretical aspects of plasma diagnostic based on the feature of satellite structures shape in hot dense plasma, which led to development of the proposed method, are also explained

Analysis of Ly_α Dielectronic Satellites to Characterize Temporal Profile of Intense Femtosecond Laser Pulses

In the paper, an X-ray spectroscopy-based approach on laser pulse temporal profile characterization is described. The structure of dielectronic satellites to H-like Lyα lines strongly depends on a plasma electron density, so it can be applied for diagnostics. These spectral lines are mainly emitted during initial stage of laser plasma expansion. It means that plasma parameters obtained via them characterizes matter conditions in a region surrounding a spot of laser-matter interaction. In the case when a laser contrast is high enough, the radiation interacts with cold matter, which had not been preliminary perturbed by a laser prepulse, and the satellites structure shape corresponding to high densities should be observed. It allows us to consider the satellites as a diagnostic tool for the laser temporal profile quality. In the paper dependencies of the dielectronic satellites structure on electron densities obtained from detailed kinetic calculations in the wide range of plasma parameter for different elements are under discussion. Fundamental theoretical aspects of plasma diagnostic based on the feature of satellite structures shape in hot dense plasma, which led to development of the proposed method, are also explained

PNPLA3 rs738409 associates with alcoholic liver cirrhosis but not with serum levels of IL6, IL10, IL8 or CCL2 in the Russian population

Introduction and aim: Polymorphic variant rs738409 within the PNPLA3 gene associates with alcoholic liver cirrhosis (ALC) in heavy drinkers of various ancestry but has not yet been established in the Russian population characterized by high incidence of ALC. PNPLA3 rs738409 involvement in the inflammatory process has been proposed as one of the mechanisms of liver dysfunction. Relationship between the PNPLA3 polymorphism and the biochemical markers of inflammation in patients with ALC remains unclear. The current study revealed the association between the rs738409 polymorphism, liver cirrhosis and serum cytokines in heavy drinkers in the Russian population. Materials and methods: The serum levels of IL6, IL10, IL8, and CCL2 along with PNPLA3 rs738409 polymorphism were determined in heavy drinkers (AA, n = 71) and heavy drinkers with diagnosed liver cirrhosis (ALC, n = 110). All of the recruited individuals were Caucasians and belonged to the Russian population. Results: Heavy drinkers carrying PNPLA3 rs738409 CG or CG+GG genotypes as compared with CC genotype carriers or G allele as compared with C allele carriers had significant risk of ALC. In ALC levels of interleukins and CCL2 increased as compared with AA. PNPLA3 rs738409 CC carriers had lower cirrhosis stage as compared with CG+GG carriers, however there were no differences of IL6, IL10, IL8 or CCL2 levels between G allele carriers and non-carriers in heavy drinkers. Conclusion: Thus, in the Russian population heavy drinkers carrying PNPLA3 rs738409 G allele are at higher risk of ALC, however the presence of rs738409 allele does not influence the serum cytokine levels

Analysis of Lyα Dielectronic Satellites to Characterize Temporal Profile of Intense Femtosecond Laser Pulses

In the paper, an X-ray spectroscopy-based approach on laser pulse temporal profile characterization is described. The structure of dielectronic satellites to H-like Lyα lines strongly depends on a plasma electron density, so it can be applied for diagnostics. These spectral lines are mainly emitted during initial stage of laser plasma expansion. It means that plasma parameters obtained via them characterizes matter conditions in a region surrounding a spot of laser-matter interaction. In the case when a laser contrast is high enough, the radiation interacts with cold matter, which had not been preliminary perturbed by a laser prepulse, and the satellites structure shape corresponding to high densities should be observed. It allows us to consider the satellites as a diagnostic tool for the laser temporal profile quality. In the paper dependencies of the dielectronic satellites structure on electron densities obtained from detailed kinetic calculations in the wide range of plasma parameter for different elements are under discussion. Fundamental theoretical aspects of plasma diagnostic based on the feature of satellite structures shape in hot dense plasma, which led to development of the proposed method, are also explained

Overview of the 10^22 Experiment

We present an overview of our recent experiment on achieving ultra-high on-target intensities, reaching efficient conversion of laser radiation to hard x-rays ("Gamma Flash"), and generating intense coherent soft x-rays (high-order harmonics). Our international team used the J-KAREN-P laser facility at KPSI QST and irradiated solid targets with intensities close to 1022 W/cm2. We employed a broad range of diagnostics, including laser, plasma, secondary radiation (from NIR to MeV x-rays) and particle (e-, p+) diagnostics, and controlled preplasma using several laser contrast modes and artificial prepulse. In this presentation we overview the experiment and simulations dedicated to it, and show first results on hard x-ray and harmonic generation, x-ray spectroscopy, and preplasma analysis.Opto-2020 Symposium on Photon and Beam Scienc

Overview of the 10^22 Experiment with the J-KAREN-P laser

Ultra-high intensities open a way towards Terawatt and potentially Petawatt gamma-ray pulses in the so called Gamma Flare regime. We performed our first experiment towards this regime with the J-KAREN-P laser operating at intensities close to 10^22 W/cm^2. In this presentation I will overview the experiment, including very bright hard x-ray generation (sub-MeV to a few-MeV spectral range), high-order harmonic generation (30 to 70 eV), and multiple additional diagnostics revealing information on preplasma (properties of reflected 1st, 2nd, and 3rd harmonics and back-reflection). I will compare these results with the integrated HD and PIC simulations.OPTO-2021 Symposium on Photon and Beam Scienc

X-ray generation at intensities approaching 10^22 W/cm^2

Generation of bright sources of hard and soft x-rays is one of the most promising applications of high-power lasers. We report on our first experiment on achieving ultra-high on-target intensities, reaching efficient conversion of laser radiation to hard x-rays (towards the "Gamma Flash" regime [1-3]), and generating intense high-order harmonics [4]. Our international team (Japan, Czech Republic, Russia, UK) used the J-KAREN-P laser facility at KPSI QST, Japan [5-8] and irradiated solid targets with intensities close to 1022 W/cm2. We employed a broad range of diagnostics, including laser, plasma, secondary radiation (from NIR to MeV x-rays) and particle (e-, p+) diagnostics, and controlled the preplasma scale length, which is a critical parameter for both hard x-ray [1,3] and harmonic generation [4]. Here we overview the experiment and dedicated simulations, and show first results on hard x-ray and harmonic generation, x-ray spectroscopy, and preplasma analysis.We thank the J-KAREN-P laser operation group. We acknowledge financial support from ELI-Beamlines, High Field Initiative Project (CZ.02.1.01/0.0/0.0/15\_003/0000449) from the European Regional Development Fund, JSPS JP 17F17811 and 19H00669, QST-IRI, and QST Director Funds 創成的研究#16 and #20.[1]T. Nakamura, et al., Phys. Rev. Lett., 2012, 108 195001.[2]C. P. Ridgers, et al., Phys. Rev. Lett. 2012, 108, 165006.[3]K. V. Lezhnin, P. V. Sasorov, G. Korn, and S. V. Bulanov, Phys. Plasmas, 2018, 25, 123105.[4]U. Teubner and P. Gibbon, Rev. Mod. Phys., 2009, 81, 445.[5]A. S. Pirozhkov, et al., Opt. Express, 2017, 25, 20486.[6]H. Kiriyama, et al., Opt. Lett., 2018, 43, 2595.[7]H. Kiriyama, et al., Opt. Lett., 2020, 45, 1100.[8]H. Kiriyama, et al., Crystals., 2020, 10, 783.International Conference on X-Ray Laser 202