PRIORITY MANAGEMENT – A DIRECTION TOWARDS COMPETITIVENESS

In a time when the most of us have to cope with globalization, the key for surpassing the negative effects produced by it, resides in choosing the right strategy. This necessary involves a performance management. Through this paper we propose priority management as an efficient way of thinking about gaining the vital competitive advantage.priority management, the Pareto law, 1-3-6 method, competitiveness, efficiency

COMPETITIVE INTELLIGENCE

There are many challenges to face in this century. It’s an era of information. Those who have the best information are going to win the race for supremacy on the market. More and more managers are aware of the fact that they have to do something to remain on the market and to be successful. They have to adapt and to try to gain an advantage over the competitors. Nowadays, the only thing that makes the difference is the company’s competitiveness. The times when the one who had the capacity to produce more was the leader are long gone; now all the actors on every market are focused on quality and this leads to severe competition. What is left then? How can a company gain competitive advantage? The only thing that can make a difference is not the quality of the product but the quality of the information they posses about the market, the client, the product, the technological process, management etc. It’s about the information management. It’s about competitive intelligence.competitive intelligence, information, intelligence, strategy

AGEs and Glucose Levels Modulate Type I and III Procollagen mRNA Synthesis in Dermal Fibroblasts Cells Culture

In the dermis, fibroblasts play an important role in the turnover of the dermal extracellular matrix. Collagen I and III, the most important dermal proteins of the extracellular matrix, are progressively altered during ageing and diabetes. For mimicking diabetic conditions, the cultured human dermal fibroblasts were incubated with increasing amounts of AGE-modified BSA and D-glucose for 24 hours. The expression of procollagen α2(I) and procollagen α1(III) mRNA was analyzed by quantitative real-time PCR. Our data revealed that the treatment of fibroblasts with AGE-modified BSA upregulated the expression of procollagen α2(I) and procollagen α1(III) mRNA in a dose-dependent manner. High glucose levels mildly induced a profibrogenic pattern, increasing the procollagen α2(I) mRNA expression whereas there was a downregulation tendency of procollagen α1(III) mRNA

Aspects Regarding the Impact of Energy Recovery from Domestic Waste on Atmosphere

The issue of domestic waste neutralization appeared with human civilization but got new dimensions in the context of the present consumer society. The diversity and increasing quantity of domestic waste imposed finding new methods for its neutralization, grouped into two categories, namely recycling and recovery. In the category of domestic waste recovery methods, incineration is mentioned among others. The main drawback of the incineration process is air pollution, which is present when the implementation of gaseous pollutant retention solutions at the source generation is avoided. In order to identify the areas that are potential sources of pollution, the present paper focuses on the dispersion modelling of gaseous pollutants from domestic waste incineration

Study on the Sludge Capitalization as a Fertilizer for Ornamental Garden Plants

The paper aimed to demonstrate that the sludge from wastewater treatment plants can be used efficiently as a fertilizer in horticulture because in the near future the storage of this sludge will become a problem. For this reason, we approached the study on the recovery of the sludge from the wastewater treatment plant of Brăila as fertilizer in the crops of ornamental garden plants that are not intended for consumption. The correct management of the sludge from wastewater treatment plants may bring a positive contribution to the vegetation development rate. The main objective of the sludge treatment is the capitalization and the decrease of negative impact on the environment

The relationship between gut microbiota and spontaneous bacterial peritonitis in patients with liver cirrhosis - a literature review

Gut microbiota is an essential component in the pathogenesis of liver cirrhosis and its complications. There is a direct relationship between the gut and the liver called the gutliver axis through which bacteria can reach the liver through the portal venous blood. However, it remains unclear how bacteria leave the intestine and reach the fluid collection in the abdomen. A series of mechanisms have been postulated to be involved in the pathogenesis of spontaneous bacterial peritonitis (SBP) and other complications of liver cirrhosis, including bacterial translocation, bacterial overgrowth, altered intestinal permeability and dysfunctional immunity. The hepatic function may also be affected by the alteration of intestinal microbiota composition. Current treatment in SBP is antibiotic therapy, but lately, probiotics have been the useful treatment suggested to improve the intestinal barrier and prevent bacterial translocation. However, studies are contradictory regarding their usefulness. In this review, we will summarize the literature data on the pathogenesis of spontaneous bacterial peritonitis concerning the existence of a relationship with the microbiota and the useful use of probiotics

In vivo bioassay to test the pathogenicity of missense human AIP variants

Background Heterozygous germline loss-of-function mutations in the aryl hydrocarbon receptor-interacting protein gene (AIP) predispose to childhood-onset pituitary tumours. The pathogenicity of missense variants may pose difficulties for genetic counselling and family follow-up. Objective To develop an in vivo system to test the pathogenicity of human AIP mutations using the fruit fly Drosophila melanogaster. Methods We generated a null mutant of the Drosophila AIP orthologue, CG1847, a gene located on the Xchromosome, which displayed lethality at larval stage in hemizygous knockout male mutants (CG1847exon1_3 ). We tested human missense variants of ‘unknown significance’, with ‘pathogenic’ variants as positive control. Results We found that human AIP can functionally substitute for CG1847, as heterologous overexpression of human AIP rescued male CG1847exon1_3 lethality, while a truncated version of AIP did not restore viability. Flies harbouring patient-specific missense AIP variants (p.C238Y, p.I13N, p.W73R and p.G272D) failed to rescue CG1847exon1_3 mutants, while seven variants (p.R16H, p.Q164R, p.E293V, p.A299V, p.R304Q, p.R314W and p.R325Q) showed rescue, supporting a non-pathogenic role for these latter variants corresponding to prevalence and clinical data. Conclusion Our in vivo model represents a valuable tool to characterise putative disease-causing human AIP variants and assist the genetic counselling and management of families carrying AIP variants

The influence of toxic metals As, Cd, Ni, and Pb on nutrients accumulation in Mentha piperita

Medicinal plants are, for a considerable part of the population, an important source of treatment for certain diseases. They contain essential nutrients for the human body such as magnesium, iron and zinc. The present study shows the influence of the addition of As, Cd, Ni, Pb on mineral nutrients in different organs of Mentha piperita. The experiments were carried out in the laboratory for a period of three months (May-July). Mentha piperita plants were AsCd and AsCdNiPb exposed up to final concentrations corresponding to the soil intervention threshold according to Romanian Order no.756/1997 (25 mg/kg As, 5 mg/kg Cd, 150 mg/kg Ni and 100 mg/ kg Pb). Simultaneously with these experiments, a control experiment (M) was performed. To evaluate the effect of the addition of AsCd and AsCdNiPb on the accumulation and transfer of Ca, Cr, Cu, Mn, Mo, Fe and Zn, the transfer coefficient (TC), the translocation factor (TF), and the enrichment factor (EF) were calculated. A higher concentration of Ca, Cr, Cu, Fe, Mn, Mo, and Zn was observed especially in the mint root in the experiments in which AsCdNiPb was added compared to those in which only AsCd was added. The AsCdNiPb addition did not influence the translocation of micro and macronutrients from the root to the aerial (edible) parts of the plant. In the case of the AsCd, addition, the translocation of zinc from the root to the aerial parts (leaves and stem) of the plant was increased

Orbital complications of acute rhinosinusitis

Introduction. Rhinosinusitis is the infection and inflammation of at least one of the 4 paranasal sinuses (frontal, maxillary, ethmoid and sphenoid). Their correct diagnosis is generally determined by examining the patient clinically and by rhinosinusal endoscopic examination. There are also cases that show complications or continued evolution despite the correct treatment, and then we will use some imaging investigations to find out more about affection(radiography of anterior sinuses of the face, sinus computerized tomography, sinus magnetic resonance imaging). In particular, acute rhinosinusitis should be carefully managed to avoid complications such as the local ones: orbital cellulitis, orbital abscess, osteomyelitis, cavernous sinus thrombosis; and intracranial complications: meningitis, epidural abscess, subdural abscess, cerebral abscess.Materials and methods. There will be presented all orbital complications according to the cases treated in the ENT Clinic of the Coltea Clinical Hospital.Conclusions. Diagnosis of rhinosinusitis is largely clinical and endoscopic.When complications of the condition arise, these should be investigated imagistically to determine their exact extent and to institute the correct treatment as soon as possible. The complications of rhinosinusitis are medical and surgical life-threatening emergencies, which is why in order to diagnose and correct and quickly institute therapy requires a multidisciplinary approach

Ranking the dietary treatments of broiler chickens in order to reduce nitrogen pollution of the environment

The Analytical Hierarchy Process (AHP) methodology was used to rank the tested nutritional solutions and to choose the best nutritional solution in order to reduce environmental pollution with nitrogen. The evaluation methodology consisted in comparing by three evaluators the diets based on the zootechnical performances/thigh meat quality / environmental impact. The diets of tested nutritional solutions were contained either medicinal and aromatic plants (basil, thyme, sage) in a proportion of 1% (batch 2), respectively essential oils (0.05%) of the same plants (batch 1). The application of the AHP methodology indicated that the best nutritional alternative was obtained for basil, either in the form of essential oil or vegetal material