Calidad de vida relacionada con la salud en estudiantes universitarios de primer año

Objetive: To evaluate the health-related quality of life (HRQoL) of first-year university students at the University of Chile in 2015 Material and Method: Observational, transversal, and analytical study of first year students, 17 to 18 years of age, attending 14 Faculties, 2 Institutes, and 1 Bachelor Program of the University of Chile. Delivery of Kidscreen-52 test by email to 3,738 students, of which 1,277 replied (34.16%). The Winsteps program model and Rasch punctuation were used. Results: The dimensions Physical Well-being, State of Mood and Emotions, and Autonomy scored less than 42 Rasch points, and the other two dimensions – Psychological Well-being and Friends and Social Support - had significantly lower scores than those found in Chilean adolescents of a comparable age, in women, in students of lower socio-economical levels in municipal public schools with a Scholar Vulnerability Index, or those with a disability, health problem, or chronic illness. The differences are greater in Faculties with heavier academic demands. Discussion: This first study gives new information in an area seldom studied, which is important for students, academics, and authorities. It is suspected that similar results would be found in other university settings. Conclusions: HRQoL studies are feasible to apply in institutions of higher education, to benefit both students and educators. This study contributes to the diagnosis and evaluation of public policies on student support, and for teaching strategies. In the near future, HRQoL instruments could be applied with other students and other members of the university community, in combination with studies on risk factors.Objetivo: Calidad de Vida Relacionada con la Salud (CVRS) en estudiantes universitarios de primer año. Material y Método: Estudio observacional, transversal y analítico en estudiantes de 17 a 18 años de primer año de 14 Facultades, 2 Institutos y 1 Programa de Bachillerato. Se aplicó el test Kidscreen-52, enviado por correo electrónico a 3.738 estudiantes. Contestaron 1.277 (34,16%). Análisis con programa WINSTEPS y expresión con puntajes Rasch. Resultados: Las dimensiones Bienestar Físico, Estado de Ánimo y Emociones y Autonomía con menos de 42 puntos Rasch, y otras dos, Bienestar Psicológico, Amigos y Apoyo Social tuvieron puntajes significativamente menores a lo encontrado en adolescentes chilenos de edad comparable, en mujeres, escolares de establecimientos municipales de bajo nivel socioeconómico, con Índice de Vulnerabilidad Escolar (IVE) o con discapacidad o problema de salud o enfermedad crónica. Las diferencias son mayores en Facultades con más demanda académica. Este primer estudio revela información no conocida, trascendente para estudiantes, académicos y sus autoridades. Se sospecha que posiblemente ocurre en otras universidades. Conclusiones: Los estudios de Calidad de Vida estudiantil son factibles de aplicar en instituciones de educación superior en beneficio de educandos y educadores. Este estudio es un insumo para diagnóstico y evaluación de las políticas salud y apoyo estudiantil y aporta a la orientación de la docencia. En el futuro podrían aplicarse instrumentos de medición de la Calidad de Vida en estudiantes de otras edades y en otros estamentos universitarios con test validados en Chile, combinado con estudios de Factores de Riesgo

Targeting of arenavirus RNA synthesis by a carboxamide-derivatized aromatic disulfide with virucidal activity.

Several arenaviruses can cause severe hemorrhagic fever (HF) in humans, representing a public health threat in endemic areas of Africa and South America. The present study characterizes the potent virucidal activity of the carboxamide-derivatized aromatic disulfide NSC4492, an antiretroviral zinc finger-reactive compound, against Junín virus (JUNV), the causative agent of Argentine HF. The compound was able to inactivate JUNV in a time and temperature-dependent manner, producing more than 99 % reduction in virus titer upon incubation with virions at 37 °C for 90 min. The ability of NSC4492-treated JUNV to go through different steps of the multiplication cycle was then evaluated. Inactivated virions were able to bind and enter into the host cell with similar efficiency as control infectious particles. In contrast, treatment with NSC4492 impaired the capacity of JUNV to drive viral RNA synthesis, as measured by quantitative RT-PCR, and blocked viral protein expression, as determined by indirect immunofluorescence. These results suggest that the disulfide NSC4492 targets on the arenavirus replication complex leading to impairment in viral RNA synthesis. Additionally, analysis of VLP produced in NSC4492-treated cells expressing JUNV matrix Z protein revealed that the compound may interact with Z resulting in an altered aggregation behavior of this protein, but without affecting its intrinsic self-budding properties. The potential perspectives of NSC4492 as an inactivating vaccinal compound for pathogenic arenaviruses are discussed.Fil: Sepúlveda, Claudia Soledad. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Quimica Biologica;Fil: Garcia, Cybele. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Quimica Biologica;Fil: Levingston Mac Leod, Jesica Mariana. Consejo Nacional de Invest.cientif.y Tecnicas. Oficina de Coordinacion Administrativa Pque. Centenario. Instituto de Cs. y Tecnologia "dr. Cesar Milstein";Fil: Lopez, Nora Mabel. Consejo Nacional de Invest.cientif.y Tecnicas. Oficina de Coordinacion Administrativa Pque. Centenario. Instituto de Cs. y Tecnologia "dr. Cesar Milstein";Fil: Damonte, Elsa Beatriz. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Quimica Biologica

Health-related quality of life of first-year university students

Objetivo: Calidad de Vida Relacionada con la Salud (CVRS) en estudiantes universitarios de primer año. Material y Método: Estudio observacional, transversal y analítico en estudiantes de 17 a 18 años de primer año de 14 Facultades, 2 Institutos y 1 Programa de Bachillerato. Se aplicó el test Kidscreen-52, enviado por correo electrónico a 3.738 estudiantes. Contestaron 1.277 (34,16%). Análisis con programa WINSTEPS y expresión con puntajes Rasch. Resultados: Las dimensiones Bienestar Físico, Estado de Ánimo y Emociones y Autonomía con menos de 42 puntos Rasch, y otras dos, Bienestar Psicológico, Amigos y Apoyo Social tuvieron puntajes significativamente menores a lo encontrado en adolescentes chilenos de edad comparable, en mujeres, escolares de establecimientos municipales de bajo nivel socioeconómico, con Índice de Vulnerabilidad Escolar (IVE) o con discapacidad o problema de salud o enfermedad crónica. Las diferencias son mayores en Facultades con más demanda académica. Este primer estudio revela información no conocida, trascendente para estudiantes, académicos y sus autoridades. Se sospecha que posiblemente ocurre en otras universidades. Conclusiones: Los estudios de Calidad de Vida estudiantil son factibles de aplicar en instituciones de educación superior en beneficio de educandos y educadores. Este estudio es un insumo para diagnóstico y evaluación de las políticas salud y apoyo estudiantil y aporta a la orientación de la docencia. En el futuro podrían aplicarse instrumentos de medición de la Calidad de Vida en estudiantes de otras edades y en otros estamentos universitarios con test validados en Chile, combinado con estudios de Factores de Riesgo.Objetive: To evaluate the health-related quality of life (HRQoL) of first-year university students at the University of Chile in 2015 Material and Method: Observational, transversal, and analytical study of first year students, 17 to 18 years of age, attending 14 Faculties, 2 Institutes, and 1 Bachelor Program of the University of Chile. Delivery of Kidscreen-52 test by email to 3,738 students, of which 1,277 replied (34.16%). The Winsteps program model and Rasch punctuation were used. Results: The dimensions Physical Well-being, State of Mood and Emotions, and Autonomy scored less than 42 Rasch points, and the other two dimensions – Psychological Well-being and Friends and Social Support - had significantly lower scores than those found in Chilean adolescents of a comparable age, in women, in students of lower socio-economical levels in municipal public schools with a Scholar Vulnerability Index, or those with a disability, health problem, or chronic illness. The differences are greater in Faculties with heavier academic demands. Discussion: This first study gives new information in an area seldom studied, which is important for students, academics, and authorities. It is suspected that similar results would be found in other university settings. Conclusions: HRQoL studies are feasible to apply in institutions of higher education, to benefit both students and educators. This study contributes to the diagnosis and evaluation of public policies on student support, and for teaching strategies. In the near future, HRQoL instruments could be applied with other students and other members of the university community, in combination with studies on risk factors