An interactive retrieval system for clinical trial studies with context-dependent protocol elements.

A well-defined protocol for a clinical trial guarantees a successful outcome report. When designing the protocol, most researchers refer to electronic databases and extract protocol elements using a keyword search. However, state-of-the-art database systems only offer text-based searches for user-entered keywords. In this study, we present a database system with a context-dependent and protocol-element-selection function for successfully designing a clinical trial protocol. To do this, we first introduce a database for a protocol retrieval system constructed from individual protocol data extracted from 184,634 clinical trials and 13,210 frame structures of clinical trial protocols. The database contains a variety of semantic information that allows the filtering of protocols during the search operation. Based on the database, we developed a web application called the clinical trial protocol database system (CLIPS; available at https://corus.kaist.edu/clips). This system enables an interactive search by utilizing protocol elements. To enable an interactive search for combinations of protocol elements, CLIPS provides optional next element selection according to the previous element in the form of a connected tree. The validation results show that our method achieves better performance than that of existing databases in predicting phenotypic features

An interactive retrieval system for clinical trial studies with context-dependent protocol elements.

A well-defined protocol for a clinical trial guarantees a successful outcome report. When designing the protocol, most researchers refer to electronic databases and extract protocol elements using a keyword search. However, state-of-the-art database systems only offer text-based searches for user-entered keywords. In this study, we present a database system with a context-dependent and protocol-element-selection function for successfully designing a clinical trial protocol. To do this, we first introduce a database for a protocol retrieval system constructed from individual protocol data extracted from 184,634 clinical trials and 13,210 frame structures of clinical trial protocols. The database contains a variety of semantic information that allows the filtering of protocols during the search operation. Based on the database, we developed a web application called the clinical trial protocol database system (CLIPS; available at https://corus.kaist.edu/clips). This system enables an interactive search by utilizing protocol elements. To enable an interactive search for combinations of protocol elements, CLIPS provides optional next element selection according to the previous element in the form of a connected tree. The validation results show that our method achieves better performance than that of existing databases in predicting phenotypic features

Characteristics of Hydrothermal Carbonization Hydrochar Derived from Cattle Manure

The characteristics of hydrothermal carbonization hydrochar derived from cattle manure including excrements and lignocellulosic biomass were analyzed. The effects of hydrothermal carbonization were evaluated by varying the reaction temperatures in the range of 180~240 °C. The hydrochars were evaluated with respect to their usefulness as renewable fuels via physicochemical analysis and pyrolysis processes. As reaction temperatures increased, the fractions of fixed carbon in proximate analyses, carbon elements in ultimate analyses, and higher heating values of hydrothermally carbonized biochars increased in correlation with the primary reactions of coalification. Various correlations were derived with the characteristics of hydrochars in order to be utilized for operating and designing HTC reactors for cattle manure. The correlation between the O/C and H/C ratios was deduced on the basis of a van Krevelen diagram. The interaction equation was represented with the increased fraction of HHV compared to the reaction temperature of hydrothermal carbonization. The ultimate correlation for the estimation of higher heating values was suggested for HTC hydrochars. Moreover, the pyrolysis characteristics and kinetic parameters of the cattle manure and hydrochar were deduced by utilizing a multi-step kinetic model scheme. As the HTC reaction temperature increased, the global activation energy and the pre-exponential factors of hydrochars decreased in the low-temperature section and increased in the high-temperature section