Nanopillar Arrays on Semiconductor Membranes as Electron Emission Amplifiers

A new transmission-type electron multiplier was fabricated from silicon-on-insulator (SOI) material by integrating an array of one dimensional (1D) silicon nanopillars onto a two dimensional (2D) silicon membrane. Primary electrons are injected into the nanopillar-membrane system from the flat surface of the membrane, while electron emission from the other side is probed by an anode. The secondary electron yield (SEY) from nanopillars is found to be about 1.8 times that of plane silicon membrane. This gain in electron number is slightly enhanced by the electric field applied from the anode. Further optimization of the dimensions of nanopillars and membrane and application of field emission promise an even higher gain for detector applications and allow for probing of electronic/mechanical excitations in nanopillar-membrane system excited by incident particles or radiation.Comment: 4 figure

Charge states and magnetic ordering in LaMnO3/SrTiO3 superlattices

We investigated the magnetic and optical properties of [(LaMnO3)n/(SrTiO3)8]20 (n = 1, 2, and 8) superlattices grown by pulsed laser deposition. We found a weak ferromagnetic and semiconducting state developed in all superlattices. An analysis of the optical conductivity showed that the LaMnO3 layers in the superlattices were slightly doped. The amount of doping was almost identical regardless of the LaMnO3 layer thickness up to eight unit cells, suggesting that the effect is not limited to the interface. On the other hand, the magnetic ordering became less stable as the LaMnO3 layer thickness decreased, probably due to a dimensional effect.Comment: 17 pages including 4 figures, accepted for publication in Phys. Rev.

Generation of mechanical squeezing via magnetic dipoles on cantilevers

A scheme to squeeze the center-of-mass motional quadratures of a quantum mechanical oscillator below its standard quantum limit is proposed and analyzed theoretically. It relies on the dipole-dipole coupling between a magnetic dipole mounted on the tip of a cantilever to equally oriented dipoles located on a mesoscopic tuning fork. We also investigate the influence of several sources of noise on the achievable squeezing, including classical noise in the driving fork and the clamping noise in the oscillator. A detection of the state of the cantilever based on state transfer to a light field is considered. We investigate possible limitations of that scheme.Comment: 11 pages, 11 figures, submitted to PR

Traversable Wormholes Construction in 2+1 Dimensions

We study traversable Lorentzian wormholes in the three-dimensional low energy string theory by adding some matter source involving a dilaton field. It will be shown that there are two-different types of wormhole solutions such as BTZ and black string wormholes depending on the dilaton backgrounds, respectively. We finally obtain the desirable solutions which confine exotic matter near the throat of wormhole by adjusting NS charge.Comment: 12 pages, 4 figures, JHEP style, one reference adde

The natural alkaloid Jerantinine B has activity in acute myeloid leukemia cells through a mechanism involving c-Jun

© 2020 The Author(s). Background: Acute myeloid leukemia (AML) is a heterogenous hematological malignancy with poor long-term survival. New drugs which improve the outcome of AML patients are urgently required. In this work, the activity and mechanism of action of the cytotoxic indole alkaloid Jerantinine B (JB), was examined in AML cells. Methods: We used a combination of proliferation and apoptosis assays to assess the effect of JB on AML cell lines and patient samples, with BH3 profiling being performed to identify early effects of the drug (4 h). Phosphokinase arrays were adopted to identify potential driver proteins in the cellular response to JB, the results of which were confirmed and extended using western blotting and inhibitor assays and measuring levels of reactive oxygen species. Results: AML cell growth was significantly impaired following JB exposure in a dose-dependent manner; potent colony inhibition of primary patient cells was also observed. An apoptotic mode of death was demonstrated using Annexin V and upregulation of apoptotic biomarkers (active caspase 3 and cleaved PARP). Using BH3 profiling, JB was shown to prime cells to apoptosis at an early time point (4 h) and phospho-kinase arrays demonstrated this to be associated with a strong upregulation and activation of both total and phosphorylated c-Jun (S63). The mechanism of c-Jun activation was probed and significant induction of reactive oxygen species (ROS) was demonstrated which resulted in an increase in the DNA damage response marker γH2AX. This was further verified by the loss of JB-induced C-Jun activation and maintenance of cell viability when using the ROS scavenger N-acetyl-L-cysteine (NAC). Conclusions: This work provides the first evidence of cytotoxicity of JB against AML cells and identifies ROS-induced c-Jun activation as the major mechanism of action

BPS Electromagnetic Waves on Giant Gravitons

We find new 1/8-BPS giant graviton solutions in $AdS_5 \times S^5$, carrying three angular momenta along $S^5$, and investigate their properties. Especially, we show that nonzero worldvolume gauge fields are admitted preserving supersymmetry. These gauge field modes can be viewed as electromagnetic waves along the compact D3 brane, whose Poynting vector contributes to the BPS angular momenta. We also analyze the (nearly-)spherical giant gravitons with worldvolume gauge fields in detail. Expressing the $S^3$ in Hopf fibration ($S^1$ fibred over $S^2$), the wave propagates along the $S^1$ fiber.Comment: 25 pages, no figures, v2: references adde

Fluctuation Study of the Specific Heat of MgB2

The specific heat of polycrystalline Mg$^{11}$B$_{2}$ has been measured with high resolution ac calorimetry from 5 to 45 K at constant magnetic fields. The excess specific heat above T$_{c}$ is discussed in terms of Gaussian fluctuations and suggests that Mg$^{11}$B$_{2}$ is a bulk superconductor with Ginzburg-Landau coherence length $\xi_{0}=26$ \AA . The transition-width broadening in field is treated in terms of lowest-Landau-level (LLL) fluctuations. That analysis requires that $\xi_{0}=20$ \AA . The underestimate of the coherence length in field, along with deviations from 3D LLL predictions, suggest that there is an influence from the anisotropy of B$_{c2}$ between the c-axis and the a-b plane.Comment: Phys. Rev. B 66, 134515 (2002

1/16-BPS Black Holes and Giant Gravitons in the AdS_5 X S^5 Space

We explore 1/16-BPS objects of type IIB string theory in AdS_5 * S^5. First, we consider supersymmetric AdS_5 black holes, which should be 1/16-BPS and have a characteristic that not all physical charges are independent. We point out that the Bekenstein-Hawking entropy of these black holes admits a remarkably simple expression in terms of (dependent) physical charges, which suggests its microscopic origin via certain Cardy or Hardy-Ramanujan formula. We also note that there is an upper bound for the angular momenta given by the electric charges. Second, we construct a class of 1/16-BPS giant graviton solutions in AdS_5 * S^5 and explore their properties. The solutions are given by the intersections of AdS_5 * S^5 and complex 3 dimensional holomorphic hyperspaces in C^{1+5}, the latter being the zero loci of three holomorphic functions which are homogeneous with suitable weights on coordinates. We investigate examples of giant gravitons, including their degenerations to tensionless strings.Comment: 25 pages, no figures, v2: references added, comments added in the conclusio